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  4. Recombinant Mouse Cell surface glycoprotein MUC18 (Mcam), partial

Recombinant Mouse Cell surface glycoprotein MUC18 (Mcam), partial

  • 货号：
    CSB-YP823168MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP823168MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP823168MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP823168MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP823168MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Mcam; Muc18; Cell surface glycoprotein MUC18; Gicerin; Melanoma cell adhesion molecule; Melanoma-associated antigen MUC18; CD antigen CD146
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.
  • 基因功能参考文献：
    1. findings suggest that MCAM is a gene upregulated and involved in maintaining PPARgamma induction in the late but not in the early stages of 3T3-L1 fibroblasts adipogenesis. PMID: 29468504
    2. The dynamic expression of CD146 controls the behavior of ECs and pericyte. PMID: 28827364
    3. In summary, we have shown that MUC18/Muc18 may serve as a regulator of airway inflammation and mucus overproduction, two important features of type 2-high asthma. Our data suggest that MUC18/Muc18 or its downstream signaling mediators may be targets for potential therapeutic agents. PMID: 28451734
    4. These findings identify CD146 as a novel retention signal that traps macrophages within the artery wall, and a promising therapeutic target in atherosclerosis treatment. PMID: 28084332
    5. Activation of the proteolytic processing of short isoform CD146, in particular by soluble CD146, constitutes a promising pathway to improve endothelial progenitors' regenerative properties for the treatment of cardiovascular diseases. PMID: 27170199
    6. Study shows that Mcam is upregulated in cells that have a migratory phenotype upon MEIS1 overexpression and identi fi ed a MEIS1 consensus site 113 kb upstream of the Mcam tran- scriptional start site. PMID: 27583552
    7. Different intrinsic co-factors in different K1735 sublines, which modulate the functions of MCAM/MUC18 in the cells that interact differently to the tumor microenvironment, may render sublines manifest differently in tumorigenicity and metastasis in vivo. PMID: 27510563
    8. Results provide evidence that MUC18 promotes viral infections both in vivo and in vitro. PMID: 27701461
    9. Microphthalmia-associated transcription factor regulates skin melanoblast migration by repressing the melanoma cell adhesion molecule PMID: 26284703
    10. Data show that CD146 was significantly higher expressed on tumor endothelium than on the liver. PMID: 26503468
    11. Conditional knockout of the cd146 gene in the murine endothelium or disruption of netrin-CD146 interaction by a specific anti-CD146 antibody blocks or reduces netrin-1-induced angiogenesis. PMID: 25656845
    12. MCAM is expressed by encephalitogenic CD8+ T lymphocytes in experimental autoimmune encephalomyelitis. Blocking or depleting MCAM in vivo reduces chronic neurological deficits in active, transfer, and spontaneous progressive EAE models. PMID: 25869475
    13. Study demonstrate for the fi rst time that host CD146 contributes to hematogenous melanoma cell metastasis through a novel mechanism involving the VEGF/FAK/Ve-cadherin network. PMID: 25449773
    14. Suggest endothelial CD146 as a target for specific drug delivery in hepatocellular carcinoma. PMID: 25238265
    15. CD146 plays a dual role on endothelium, facilitating leukocyte extravasations and angiogenesis, thus promoting inflammation. PMID: 24767106
    16. CD146 deletion in the nervous system impairs appetite, locomotor activity and spatial learning in mice. PMID: 24040184
    17. Identified a novel negative regulator of angiogenesis, microRNA 329 (miR-329), that directly targeted CD146 and inhibited CD146-mediated angiogenesis in vitro and in vivo. PMID: 23878390
    18. In addition, our data suggest that the AA98 is a promising candidate for treating MS and other CNS autoimmune diseases. PMID: 23595028
    19. Alterations in CD146 are involved in the basic etiology of COPD/pulmonary emphysema. PMID: 23649916
    20. MUC18 exerts a proinflammatory function during lung bacterial infection. PMID: 23256918
    21. Data suggest that Mcam plays role in sustaining spermatogenesis and clonogenic activity of spermatogonial stem cells (SSC); Mcam appears to be involved in homing of transplanted SSC to testicular niche (but not in apoptosis or cell proliferation). PMID: 23053437
    22. CD146 expression was significantly associated with high tumor stage, poor prognosis, and triple-negative breast cancer. PMID: 22210108
    23. MUC18 is involved in cell signaling regulating the expression of Id-1 and ATF-3, thus contributing to melanoma metastasis PMID: 21467165
    24. gicerin is an effector for the malignant progression of mammary carcinoma PMID: 14612940
    25. Two isoforms of gicerin were generated by an alternative splicing of exon 15 that results in cytoplasmic domains composed of either 63 or 21 amino acids. The mRNA content of gicerin in PC12 cells was regulated by cAMP. PMID: 15769548
    26. These findings suggest that TGF-beta1 may therefore regulate gicerin expression in hepatocytes leading to liver regeneration by cell-cell or cell-extracellular matrix interactions. PMID: 17273784
    27. These data present direct evidence for the role of CD146 in mediating embryonic attachment and trophoblastic invasion, and provide new insight into the molecular mechanism underlying unexplained pregnancy loss and recurrent miscarriage. PMID: 18288634
    28. A subset of host B lymphocytes controls melanoma metastasis through a melanoma cell adhesion molecule/MUC18-dependent interaction. PMID: 18922915
    29. study identified CD146 as a marker of mouse natural killer cell maturation that is not expressed by other lymphocyte subpopulations PMID: 18958886
    30. study concluded that increased moMCAM/MUC18 expression in the two melanoma K1735 sublines minimally affected their tumorigenicity, but it augmented their in vitro motility and invasiveness and increased their pulmonary metastasis in the syngeneic C3H mice PMID: 19010815

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Detected in melanoma cell lines.
  • 数据库链接：

    KEGG: mmu:84004

    STRING: 10090.ENSMUSP00000034650

    UniGene: Mm.275003