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  4. Recombinant Mouse Caytaxin (Atcay)

Recombinant Mouse Caytaxin (Atcay)

  • 货号：
    CSB-YP805270MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP805270MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP805270MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP805270MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP805270MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Atcay
  • Uniprot No.：
  • 别名：
    AtcayCaytaxin
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-372
  • 氨基酸序列
    MGTTEATLRM ENVDVRDEWQ DEDLPRPLPE DTGVERLGGA VEDSSSPPST LNLSGAHRKR KTLVAPEINI SLDQSEGSLL SDDFLDTPDD LDINVDDIET PDETDSLEFL GNGNELEWED DTPVATAKNM PGDSADLFGD GSAEDGSAAN GRLWRTVIIG EQEHRIDLHM IRPYMKVVTH GGYYGEGLNA IIVFAACFLP DSSSPDYHYI MENLFLYVIS SLELLVAEDY MIVYLNGATP RRRMPGIGWL KKCYHMIDRR LRKNLKSLII VHPSWFIRTV LAISRPFISV KFISKIQYVH SLEELERLIP MEHVQLPDCV LQYEEQRLRA KRESTRPPQP EFLLPRSEEK PETVEEEDRA AEATEDQETS MS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Functions in the development of neural tissues, particularly the postnatal maturation of the cerebellar cortex. May play a role in neurotransmission through regulation of glutaminase/GLS, an enzyme responsible for the production in neurons of the glutamate neurotransmitter. Alternatively, may regulate the localization of mitochondria within axons and dendrites.
  • 基因功能参考文献：
    1. Caytaxin's role in maintaining normal neuronal function PMID: 23226316
    2. Caytaxin is a novel substrate of caspase-3, which is cleaved upstream of the CRAL-TRIO/BCH domain and which regulates MEK2 signaling PMID: 21369758
    3. Mutations of mouse Atcay are an orthologous gene model for human Cayman ataxia. PMID: 14556008
    4. The classical hesitant allele of Atcay is partially suppressed by CAST/Ei alleles of the nuclear export factor Nxf1. PMID: 19436707
  • 相关疾病：
    Defects in Atcay are the cause of jittery phenotype, which is characterized by severe truncal and limb ataxia and death due to starvation and dehydration by 3-4 weeks of age.
  • 亚细胞定位：
    Cell projection, axon. Cell projection, dendrite. Cell junction, synapse, presynapse. Mitochondrion. Cell projection, growth cone. Cytoplasm.
  • 组织特异性：
    Neuronal tissues specific. Strongly expressed in brain. Expressed in virtually all parts of the adult brain, including cortex, cerebellum and olfactory bulbs. Enriched in hippocampus, cerebellar cortex, deep cerebellar nuclei, and pontine nuclei (at prote
  • 数据库链接：

    KEGG: mmu:16467

    STRING: 10090.ENSMUSP00000036721

    UniGene: Mm.127681