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  4. Recombinant Mouse Caveolin-3 (Cav3)

Recombinant Mouse Caveolin-3 (Cav3)

  • 货号：
    CSB-YP004573MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP004573MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP004573MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP004573MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP004573MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Cav3Caveolin-3; M-caveolin
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-151
  • 氨基酸序列
    MMTEEHTDLE ARIIKDIHCK EIDLVNRDPK NINEDIVKVD FEDVIAEPEG TYSFDGVWKV SFTTFTVSKY WCYRLLSTLL GVPLALLWGF LFACISFCHI WAVVPCIKSY LIEIQCISHI YSLCIRTFCN PLFAALGQVC SNIKVVLRRE G
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae.
  • 基因功能参考文献：
    1. Pathogenic p.P104 mutation causes endoplasmic reticulum stress, impairs protein processing, ECM remodeling and sarcolemmal integrity. PMID: 30153853
    2. Cav-3 and Smad3 may be involved in the occurrence and development of viral myocarditis. PMID: 28770956
    3. CAV3 protein has a physiological role in glycometabolism, growth and proliferation, independent of insulin stimulation PMID: 29206848
    4. The Cav3 P104L mutation of limb girdle muscular dystrophy-1C leads to disordered glucose metabolism in muscle cells. PMID: 28232187
    5. Cav-3 overexpressing mice have changes in ECG intervals, heart rates, and cardiac ion channel expression PMID: 27023865
    6. Loss of CAV3 interferes with downstream insulin signaling and lipid uptake and increases susceptibility to palmitate-induced insulin resistance. PMID: 27033451
    7. eNOS, caveolin-3, and connexin-43 were detected in subsarcolemmal mitochondria PMID: 25694588
    8. Data show increased expression of T-type Ca(2+) current and association of protein kinase C alpha (PKCalpha) with caveolin-3 (Cav-3)was disrupted in the hypertrophic ventricular myocyte. PMID: 26170457
    9. Cardioprotection in myocardial infarction is abolished in caveolin-3 knockout mice. PMID: 25912591
    10. The lithogenic diet was associated with significantly lower CAV3 in the liver and lower CAV3 and CCKAR in the gallbladder compared with the control mice. PMID: 25071346
    11. Cav-3 may be a novel participant in B-cell expression, T-cell cytokine production and activation of inflammation PMID: 25476831
    12. Cav3 protein can modify integrin function and mechanotransduction in the cardiomyocyte and intact heart PMID: 25366344
    13. Deinactivation of Cav3 channels increases T-type Ca(2+) influx and increases feedback inhibition in olfactory bulb. PMID: 25319700
    14. Data reveal the membrane cholesterol dependence of normoxic myocardial and coronary function, I/R tolerance, and morphine-mediated cardioprotection in murine hearts (all declining with cholesterol depletion). PMID: 25063791
    15. Cav-3 has a pivotal role in defending cardiomyocytes against the TNF pro-apoptotic action and alpha-linoleic acid has the capacity to regulate this mechanism preventing cardiac degenerative diseases. PMID: 24042018
    16. the distribution of ryanodine receptors (RyRs) and caveolin-3 (CAV3) in mouse ventricular myocytes PMID: 23746531
    17. Palmitate diet-induced loss of cardiac caveolin-3 constitutes a novel mechanism for lipid-induced contractile dysfunction. PMID: 23585895
    18. hyperglycemia-induced PKCbeta2 activation requires caveolae and is associated with reduced Cav-3 expression in the diabetic heart. PMID: 23474486
    19. Data suggest caveolin-1 (but not caveolin 3) is down-regulated in plasma membrane/caveolae/mitochondria in myocardium in acute ischemia-reperfusion injury. PMID: 23403888
    20. Inhibition of MSTN activity by overexpression of cav-3 induces an activation of protein synthesis rather than an inhibition of proteolysis. PMID: 22791505
    21. We show that a TbetaRI kinase inhibitor, Ki26894, restores impaired myoblast differentiation in vitro caused by activin, myostatin, and TGF-beta1, as well as CAV3(P104L). PMID: 22584670
    22. Cav-3 plays an essential role in adiponectin transmembrane signaling and APN anti-ischemic/cardioprotective actions. PMID: 22328772
    23. Findings suggest that the ER stress response caused by mCav3(P104L) plays a role in the pathogenesis of LGMD1C as a toxic gain of function effect. PMID: 21610159
    24. PKCdelta signaling is required for myoblast fusion by regulating the expression of caveolin-3 and beta1D integrin upstream focal adhesion kinase. PMID: 21346196
    25. Data indicate that Cav-3 increases caveolae formation and induces a "protective phenotype" that is characterized by increaed natriuretic peptide expression and decreased cardiac hypertrophy. PMID: 21616289
    26. both groups of preassembled proteins are maintained in close proximity by caveolin-3, the K(V)4.2/K(V)4.3 channel supramolecular complex, and alpha1-AR, Galphas and adenylate cyclase gather in a second group PMID: 20224290
    27. Depletion of Cav3 induced by delivery of the dominant-negative Cav3 (P104L) form impairs myoblast differentiation via Akt and p38 signalling networks, leading to an immature cell and molecular signature. PMID: 21182936
    28. functional modulation of the Ca(v)3.2 channels by Cav-3 is important for understanding the compartmentalized regulation of Ca(2+) signaling during normal and pathological processes. PMID: 21084288
    29. Opioid-induced preconditioning is dependent on Cav-3 expression and endogenous protection in Cav-3 overexpressing mice is opioid dependent. PMID: 20736437
    30. caveolin 3-containing membrane domains and the calcium release complex are functionally linked and Trisk 95 and Trisk 51 are instrumental to the regulation of this interaction, the integrity of which may be crucial for muscle physiology. PMID: 20565104
    31. Delayed delayed anesthetic preconditioning induced by isoflurane cannot be elicited in caveolin-3-deficient mice, indicating that the presence of caveolae (dependent on caveolin-3 expression) is a prerequisite for delayed protection in the myocardium. PMID: 20418694
    32. These data identify caveolin-3 as a critical component of the signaling machinery that drives nicotinic acetylcholine receptor clustering and controls neuromuscular junction function. PMID: 19940021
    33. GPI-linked proteins were retained intracellularly in tissue samples derived from Cav-1 null mice (i.e., lung endothelial and renal epithelial cells) and Cav-3 null mice (skeletal muscle fibers). PMID: 11997523
    34. Data suggest that loss of Cav-3 expression is sufficient to induce a molecular program leading to cardiac myocyte hypertrophy and cardiomyopathy. PMID: 12138167
    35. Overexpression of caveolin-3 is sufficient to induce severe cardiomyopathy. PMID: 12966035
    36. caveolin-3 is a key player in myoblast fusion PMID: 14517320
    37. caveolin-3 mutations associated with limb girdle muscular dystrophy type 1C disrupt normal cellular signal transduction pathways PMID: 14600260
    38. Recombinant expression of caveolin-3 affects subcellular localization of PFK-M, by targeting PFK-M to plasma membrane and by trans-locating PFK-M to caveolae-enriched membrane domains. Strictly dependent on the concentration of extracellular glucose. PMID: 14633633
    39. loss of caveolin-3 associated with a moderate increase in eNOS activity results in hypertrophic cardiomyopathy PMID: 14645200
    40. the importance of dysferlin-caveolin 3 relationship for skeletal muscle integrity PMID: 14749532
    41. Data suggest that caveolin 3 is an enhancer of insulin signaling in skeletal muscles but does not act as a scaffolding molecule for insulin receptors. PMID: 15314230
    42. Our results demonstrate the importance of Cav-3 in regulating whole body glucose homeostasis in vivo and its possible role in the development of insulin resistance. PMID: 15689413
    43. Caveolins are essential for dysferlin association with the plasma membrane. PMID: 16319126
    44. Flotillin-1 and caveolin-3 may regulate muscle energy metabolism through the spatial and temporal segregation of key components of the insulin signaling, including GLUT4 transport. PMID: 16455755
    45. caveolin-3 was present only in smooth muscles of some specific tissues PMID: 16609918
    46. These findings indicate that normal expression and localization of caveolin-3 are required to appropriately co-ordinate PI(3) kinase/Akt-mediated cell survival signaling. PMID: 16814768
    47. Intermediate filament protein desmin and caveolin-3 associate with each other in myogenic cells. PMID: 17036228
    48. caveolin-3 normally suppresses the myostatin-mediated signal PMID: 17039257
    49. Overexpression of CAR may lead to physiological dysfunction by interfering with normal signaling (through alterations in caveolin-3 and neuronal nitric-oxide synthase levels). PMID: 17148677
    50. caveolin-3 levels are downregulated by nitric oxide through the interaction with myogenin, the transcription factor for caveolin-3 PMID: 17519233

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  • 亚细胞定位：
    Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Cell membrane, sarcolemma.
  • 蛋白家族：
    Caveolin family
  • 组织特异性：
    Expressed predominantly in muscle.
  • 数据库链接：

    KEGG: mmu:12391

    STRING: 10090.ENSMUSP00000074922

    UniGene: Mm.3924