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  4. Recombinant Mouse Cation-dependent mannose-6-phosphate receptor (M6pr), partial

Recombinant Mouse Cation-dependent mannose-6-phosphate receptor (M6pr), partial

  • 货号：
    CSB-YP013293MO1
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP013293MO1
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP013293MO1-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP013293MO1
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP013293MO1
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    M6pr
  • Uniprot No.：
  • 别名：
    M6pr; 46mpr; Cation-dependent mannose-6-phosphate receptor; CD Man-6-P receptor; CD-MPR; 46 kDa mannose 6-phosphate receptor; MPR 46
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.
  • 基因功能参考文献：
    1. Finally, Chlamydia trachomatis infection interferes with the SNX5:cation-independent mannose-6-phosphate receptor interaction, suggesting that Chlamydia IncE and cation-independent mannose-6-phosphate receptor are dependent on the same binding surface on SNX5. PMID: 28252385
    2. We conclude that M6PR is an important receptor used by HIV-1 to cross the blood-brain barrier. PMID: 22761827
    3. Mannose receptor interacts with Fc receptors and is critical for the development of crescentic glomerulonephritis in mice PMID: 20407205
    4. Mannose 6-phosphate receptor has a role in acid sphingomyelinase deficiency PMID: 14557264
    5. in hepatocytes of MPR-deficient neonatal mice lysosomal storage occurs when both MPRs are lacking, whereas deficiency of CI-MPR only has no effect on the ultrastructure of the lysosomal system. PMID: 14585283
    6. Data characterize the retrograde transport of mannose 6-phosphate receptor MPR46 from endosomes to the trans-Golgi network by an in vitro transport assay using mouse fibroblast cell lines. PMID: 14617361
    7. there is not a an Mpr300- or Mpr46-dependent pathway of granzyme-mediated killing in internalization of monomeric and complexed granzyme B PMID: 14985351
    8. These results indicate that beta-glucuronidase transport into brain parenchyma in early postnatal life is mediated by the mannose 6-phosphate/insulin-like growth factor II receptor. PMID: 15314220
    9. Mpr46 is dispensable on target cells for lysis and apoptosis mediated by alloreactive cytotoxic T lymphocytes. PMID: 15371683
    10. The murine 46-kDa mannose 6-phosphate receptor has the capacity to deliver its cargo proteins to lysosomes even in the absence of endosomal acidification. PMID: 17105763
    11. epinephrine restores the M6P receptor-mediated functional transport of (131)I-P-beta-glucuronidase across the blood brain barrier in adults to levels seen in the neonate PMID: 17646643
    12. the alpha-galactosidase enzyme is incorporated via cation-independent mannose 6-phosphate receptors in Schwann cells PMID: 17965825

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  • 亚细胞定位：
    Lysosome membrane; Single-pass type I membrane protein.
  • 数据库链接：

    KEGG: mmu:17113

    STRING: 10090.ENSMUSP00000007602

    UniGene: Mm.249225