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  4. Recombinant Mouse Cathepsin Z (Ctsz)

Recombinant Mouse Cathepsin Z (Ctsz)

  • 货号：
    CSB-YP006206MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP006206MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP006206MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP006206MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP006206MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    CtszCathepsin Z; EC 3.4.18.1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    64-306
  • 氨基酸序列
    LPKNWDW RNVNGVNYAS VTRNQHIPQY CGSCWAHGST SAMADRINIK RKGAWPSILL SVQNVIDCGN AGSCEGGNDL PVWEYAHKHG IPDETCNNYQ AKDQDCDKFN QCGTCTEFKE CHTIQNYTLW RVGDYGSLSG REKMMAEIYA NGPISCGIMA TEMMSNYTGG IYAEHQDQAV INHIISVAGW GVSNDGIEYW IVRNSWGEPW GEKGWMRIVT STYKGGTGDS YNLAIESACT FGDPIV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity. Capable of producing kinin potentiating peptides.
  • 基因功能参考文献：
    1. The data support a novel role for cathepsin Z in the propagation of IL-1beta-driven neuroinflammation. PMID: 28486971
    2. nigericin-induced cell death depended partly on a single cathepsin, cathepsin X. PMID: 28087651
    3. tumor proliferation was exclusively regulated by cancer cell-intrinsic functions of CtsZ, whereas tumor invasion required contributions from both macrophages and cancer cell PMID: 25274726
    4. Our data show an active role for Ctsz in chronic inflammation and the development of gastric metaplasia. PMID: 23936173
    5. Plaque-associated microglial cells express gamma-enolase and cathepsin X. PMID: 23621429
    6. Cathepsins L and Z are critical in degrading polyglutamine-containing proteins within lysosomes. PMID: 22451661
    7. cathepsin Z contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma PMID: 21966391
    8. analysis of cathepsin X-deficient gastric epithelial cells in co-culture with macrophages during Helicobacter pylori infection PMID: 20736174
    9. Data show that combined loss of Ctsb and Ctsz led to additive effects, resulting in significant and prominent delay of early and advanced tumor development, improved histopathologic tumor grading and 70% reduction in the number of lung metastases. PMID: 20133781
    10. regulation of the phagosomal CatZ, CatB, CatL and CatS contents during dendritic cell activation PMID: 12186844

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  • 亚细胞定位：
    Lysosome.
  • 蛋白家族：
    Peptidase C1 family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    KEGG: mmu:64138

    STRING: 10090.ENSMUSP00000016400

    UniGene: Mm.156919