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  4. Recombinant Mouse Calcipressin-2 (Rcan2)

Recombinant Mouse Calcipressin-2 (Rcan2)

  • 中文名称：
    小鼠Rcan2重组蛋白
  • 货号：
    CSB-YP884899MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Rcan2重组蛋白
  • 货号：
    CSB-EP884899MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Rcan2重组蛋白
  • 货号：
    CSB-EP884899MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Rcan2重组蛋白
  • 货号：
    CSB-BP884899MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Rcan2重组蛋白
  • 货号：
    CSB-MP884899MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rcan2
  • Uniprot No.：
  • 别名：
    Rcan2; Dscr1l1; Zaki4; Calcipressin-2; Calcineurin inhibitory protein ZAKI-4; Down syndrome candidate region 1-like protein 1; Myocyte-enriched calcineurin-interacting protein 2; MCIP2; Regulator of calcineurin 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-197
  • 氨基酸序列
    MPAPSMDCDV STLVACVVDV EVFTNQEVKE KFEGLFRTYD ECVTFQLFKS FRRVRINFSH PKSAARARIE LHETQFRGKK LKLYFAQVQT PETDGDKLHL APPQPAKQFL ISPPSSPPVG WKPISDATPV LNYDLLYAVA KLGPGEKYEL HAGTESTPSV VVHVCDSDME EEEDPKTSPK PKIIQTRRPG LPPSVSN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.
  • 基因功能参考文献：
    1. RCANs play critical roles in bone homeostasis by regulating both osteoclastogenesis and osteoblastogenesis, and they serve as inhibitors for calcineurin-NFATc1 signaling both in vivo and in vitro. PMID: 27917924
    2. our results indicate that Rcan2 and estradiol might regulate body weight through different mechanisms in female mice. Rcan2 increases food intake and promotes weight gain, while estradiol increases energy expenditure possibly by regulating physical activity. PMID: 28624805
    3. Rcan2 and Rps6kb1 mutations both affect growth and body weight of mice, though likely through different mechanisms PMID: 27604858
    4. Rcan2 regulates osteoblast function and its expression in bone is regulated by thyroid status in vivo PMID: 22593270
    5. an Rcan2-dependent mechanism which regulates food intake and promotes weight gain through a leptin-independent pathway PMID: 21298050
    6. Genetic inhibition of calcineurin in Zaki-4 transgenic mice induces diastolic dysfunction in mice with chronic pressure overload. PMID: 19717730

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  • 蛋白家族：
    RCAN family
  • 组织特异性：
    Highest expression in heart, skeletal muscle and brain. Lower expression in all other tissues.
  • 数据库链接：

    KEGG: mmu:53901

    UniGene: Mm.251242