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  4. Recombinant Mouse COP9 signalosome complex subunit 8 (Cops8)

Recombinant Mouse COP9 signalosome complex subunit 8 (Cops8)

  • 中文名称：
    Recombinant Mouse COP9 signalosome complex subunit 8(Cops8),Yeast
  • 货号：
    CSB-YP844982MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse COP9 signalosome complex subunit 8(Cops8),Yeast
  • 货号：
    CSB-EP844982MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse COP9 signalosome complex subunit 8(Cops8),Yeast
  • 货号：
    CSB-EP844982MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse COP9 signalosome complex subunit 8(Cops8),Yeast
  • 货号：
    CSB-BP844982MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse COP9 signalosome complex subunit 8(Cops8),Yeast
  • 货号：
    CSB-MP844982MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cops8
  • Uniprot No.：
  • 别名：
    Cops8; Csn8COP9 signalosome complex subunit 8; SGN8; Signalosome subunit 8; COP9 homolog; JAB1-containing signalosome subunit 8
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-209
  • 氨基酸序列
    PVAVMADNA FSFRKLLDQC ENQELEAPGG IATPPVYGQL LALYLLQNDM NNARYLWKRI PPAIKSANSE LGGIWSVGQR IWQRDFPGIY TTINAHQWSE TVQPIMEALR DATRRRAFAL VSQAYTSIIA DDFAAFVGLP VEEAVKGVLE QGWQADSTTR MVLPRKPASG TLDVSLNRFI PLSEPAPVPP IPNEQQLARL TDYVAFLEN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
  • 基因功能参考文献：
    1. CSN8/CSN promotes the ubiquitination and degradation of misfolded proteins and protects against cardiac proteotoxicity, and cullin-RING ligases participate in degradation of cytosolic misfolded proteins. PMID: 26383969
    2. Csn8 exerts profound impacts on hepatic ubiquitin-proteasome system function and is critical to the stability of the pro-apoptotic protein Bim. PMID: 23840878
    3. CSN8/COP9 signalosome regulates both proteasome-mediated proteolysis and the autophagic-lysosomal pathway, critical to the removal of oxidized proteins in the heart. PMID: 23873473
    4. Data indicate that a decreased level of Csn8 accelerated cell growth and shortened G1 duration. PMID: 23689509
    5. Likely through regulating the expression of Rab7, Csn8/CSN plays a critical role in autophagosome maturation in myocardium. PMID: 21986281
    6. The Csn8 is essential to the ability of mature hepatocytes to proliferate effectively in response to hepatic injury. PMID: 20689553
    7. Csn8/CSN plays an essential role in cullin deneddylation, UPS-mediated degradation of a subset of proteins, and the survival of cardiomyocytes PMID: 21051661
    8. involved in the transcriptional regulation of cell-specific gene expression PMID: 18706515

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    CSN8 family
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    KEGG: mmu:108679

    STRING: 10090.ENSMUSP00000035884

    UniGene: Mm.119177