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  4. Recombinant Mouse CDK5 and ABL1 enzyme substrate 1 (Cables1)

Recombinant Mouse CDK5 and ABL1 enzyme substrate 1 (Cables1)

  • 中文名称：
    Recombinant Mouse CDK5 and ABL1 enzyme substrate 1(Cables1),Yeast
  • 货号：
    CSB-YP884155MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse CDK5 and ABL1 enzyme substrate 1(Cables1),Yeast
  • 货号：
    CSB-EP884155MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse CDK5 and ABL1 enzyme substrate 1(Cables1),Yeast
  • 货号：
    CSB-EP884155MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse CDK5 and ABL1 enzyme substrate 1(Cables1),Yeast
  • 货号：
    CSB-BP884155MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse CDK5 and ABL1 enzyme substrate 1(Cables1),Yeast
  • 货号：
    CSB-MP884155MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cables1
  • Uniprot No.：
  • 别名：
    Cables1; CablesCDK5 and ABL1 enzyme substrate 1; Interactor with CDK3 1; Ik3-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-568
  • 氨基酸序列
    MAAATATAGT AACSSSSSSR GGSTDAAATS GVQPPPPPPA TAPPEPLRKP RMDPRRRQAA LSFLTNISLD GRPPLQDHEW GGGEEGGGTK PGARARLSLL AAGCNAFSAP GTAAAPWTAG SGSSPCPLPP SLVPRVLGEP SQPPRSAPAV TGAQLQLPDG PGGAGQEELE EDDAFTNVQV PSASFLGSGT PGSTSGSRGR LNSFTQGILP IAFSRQNSQN YCALEQSGQG GSTSALEQLQ RSRRRLISQR SSLETLEDIE ENAPLRRCRT LSGSPRPKNF KKIHFIKNMR QHDTKNGRDL KLDGGRQSAG AMSLKEIIGL EGVELGADGK TVSYTQFLLP TNAFGNRRNT IDSTASFSQF RSLSHRSLSM GRAGSTQGSL DAGSDLGDFM DYDPNLLDDP QWPCGKHKRV LTFPSYMTTV IDYVKPSDLK KDMNETFKEK FPHIKLTLSK IRSLKREMRK LAQEDCGFEE PTVAMAFVYF EKLALRGKLN KQNRKLCAGA CVLLAAKVGS DLRKHEVKHL IDKLEEKFRL NRRELIAFEF PVLVALEFAL HLPEHEVMPH YRRLIQSS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death.
  • 基因功能参考文献：
    1. Loss of Cables1 enhances tumor progression in the Apc(Min/+) mouse model and activates the Wnt/beta-catenin signaling pathway. Cables1 is a tumor suppressor gene on chromosome 18q in this in vivo mouse model. PMID: 23792637
    2. Agenesis of the corpus callosum frequency in Cables1(+/TAS) mice was significantly lower than that in Cables1(-/TAS) mice, indicating that wild-type Cables1 interfered with the dominant negative effect of Cables1(TAS). PMID: 24336072
    3. Cables may be involved in the pathogenesis of ovarian carcinomas PMID: 13679449
    4. Loss or suppression of Cables may be an early step in the development of endometrial cancer. PMID: 14729625
    5. Cables is a relevant target of the chromosome 18q deletions frequently seen in human colorectal cancer. PMID: 16210915
    6. Cables1 null mice exhibit a significant expansion of oocyte numbers at the expense of oocyte quality throughout adulthood. PMID: 17912041

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Cell projection, growth cone. Note=Located in the cell body and proximal region of the developing axonal shaft of immature neurons. Located in axonal growth cone, but not in the distal part of the axon shaft or in dendritic growth cone of mature neurons.
  • 蛋白家族：
    Cyclin family
  • 组织特异性：
    Ubiquitous. Expressed in postnatal day 1 (P1), in postmitotic neurons of the subplate, cortex (V/VI) and marginal zone; in postnatal day 7 (P7), in all layers of the cerebral cortex and in the CA1 and CA2 regions of the hippocampus (at protein level). Hig
  • 数据库链接：

    KEGG: mmu:63955

    STRING: 10090.ENSMUSP00000129463

    UniGene: Mm.40717