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  4. Recombinant Mouse CD59B glycoprotein (Cd59b)

Recombinant Mouse CD59B glycoprotein (Cd59b)

  • 货号：
    CSB-YP347997MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP347997MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP347997MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP347997MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP347997MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cd59b
  • Uniprot No.：
  • 别名：
    Cd59bCD59B glycoprotein; MAC-inhibitory protein; MAC-IP; Membrane attack complex inhibition factor; MACIF; Protectin; CD antigen CD59
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    24-104
  • 氨基酸序列
    LKCYNCL DPVSSCKINT TCSPNLDSCL YAVAGRQVYQ QCWKLSDCNS NYIMSRLDVA GIQSKCCQWD LCNKNLDGLE EPNN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore.
  • 基因功能参考文献：
    1. Data (including data from studies using knockout mice) suggest that CD59a, CD59b, and ApoE are involved in development of diabetes-induced atherosclerosis; here, deficiency of CD59a/CD59b (in ApoE deficient mice) accelerates development of atherosclerosis in mice with type 1 diabetes. (CD59a = CD59a antigen; CD59b = CD59b antigen; ApoE = apolipoprotein E) PMID: 27729184
    2. Genomic structure, functional comparison, and tissue distribution of mouse Cd59a and Cd59b. PMID: 11471050
    3. Cd59b knockout mice present a phenotype characterized by hemolytic anemia, platelet activation and a progressive loss of fertility associated with immobile dysmorphic and fewer sperm cells after 5 months of age. PMID: 12594949
    4. Expression of CD59b is present on mature spermatozoa and precursors and, in trace amounts, erythrocytes, and is likely only of relevance in the male reproductive system of mouse. PMID: 15356114
    5. novel function in spermatogenesis that is most likely unrelated to its function as an inhibitor of membrane attack complex formation PMID: 16272280
    6. Reported the mapping of promoter regions of both mouse Cd59a and Cd59b genes and identified that each Cd59 gene expresses two different tissue-specific transcripts that differ at their 5'ends. PMID: 16541098
    7. Total abrogation of mCd59 function in mCd59ab(-/-) mice results in complement-mediated hemolytic anemia that is rescued by the deficiency of C3 in compound mCd59ab(-/-)/C3(-/-) mice. PMID: 19051264
    8. mCd59ab(-/-) platelets are sensitive to complement-mediated activation and provide evidence for possible in vivo platelet activation in mCd59ab(-/-) mice. PMID: 19229985

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 组织特异性：
    Widely expressed in the kidneys, brain, lungs, spleen and testis Testis specific.
  • 数据库链接：

    KEGG: mmu:333883

    STRING: 10090.ENSMUSP00000087912

    UniGene: Mm.359026