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  4. Recombinant Mouse CD48 antigen (Cd48)

Recombinant Mouse CD48 antigen (Cd48)

  • 货号：
    CSB-YP004941MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP004941MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP004941MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP004941MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP004941MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Cd48; Bcm-1CD48 antigen; BCM1 surface antigen; BLAST-1; HM48-1; MRC OX-45 surface antigen; SLAM family member 2; SLAMF2; Signaling lymphocytic activation molecule 2; sgp-60; CD antigen CD48
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    23-217
  • 氨基酸序列
    FQGHSIPD INATTGSNVT LKIHKDPLGP YKRITWLHTK NQKILEYNYN STKTIFESEF KGRVYLEENN GALHISNVRK EDKGTYYMRV LRETENELKI TLEVFDPVPK PSIEINKTEA STDSCHLRLS CEVKDQHVDY TWYESSGPFP KKSPGYVLDL IVTPQNKSTF YTCQVSNPVS SKNDTVYFTL PCDLARS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation.
  • 基因功能参考文献：
    1. Molecular dynamic simulation explains unbinding and unfolding of CD48-2B4 protein complexes. PMID: 25142868
    2. These data demonstrate the important role of CD48 in SA/exotoxins-eosinophil activating interactions that can take place during allergic responses and indicate CD48 as a novel therapeutic target for allergy and especially of AD. PMID: 25255823
    3. ORMDL3 promotes eosinophil trafficking and activation via regulation of CD18, CD49d, and CD48. PMID: 24056518
    4. Ox-LDL significantly promoted the interaction of natural killer cells and dendritic cells via CD48-2B4 contact-dependent mechanisms. PMID: 21221603
    5. B6-specific background genes modulate the effect of CD48 on lupus nephritis in a recessive manner PMID: 21561736
    6. CD48 plays a vital role as an environmental sensor for regulating hematopoietic stem cells and progenitor cell numbers and inhibiting tumor development PMID: 21576698
    7. CD48 on surrounding NK or non-NK cells serves primarily as a ligand to stimulate 2B4 on the adjacent NK cells in mice PMID: 20647560
    8. CD48 interactions with NK cell receptor 2B4 among neighboring T cells during T cell priming augment CTL lysis of their specific targets. PMID: 12734329
    9. compare the relative contributions of MHC class I and CD48 to NK cell self-tolerance; and CD244 regulates NK cell tolerance to normal cells in vivo; evidence for MHC-independent NK self-recognition in a bone marrow rejection assay PMID: 15870174
    10. Cell surface receptors of the SLAM family, including CD150, CD244, and CD48, were differentially expressed among functionally distinct hematopoietic progenitor cells. PMID: 15989959
    11. Review of recent studies suggests an important role for interactions between 2B4 and CD48 in the course of T cell activation and proliferation PMID: 16081768
    12. T cell-induced experimental colitis is ameliorated only when CD48 is absent from both T cells and antigen-presenting cells. PMID: 16472597
    13. the mechanism of signal transduction by CD244 is to regulate FYN kinase recruitment and/or activity and the outcome of CD48/CD244 interactions is determined by which other receptors are engaged. PMID: 17599905

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 数据库链接：

    KEGG: mmu:12506

    STRING: 10090.ENSMUSP00000064241

    UniGene: Mm.1738