Recombinant Mouse CCN family member 2 (Ccn2), partial

1. These results reveal a novel mechanism of macrophage migration into glomeruli with nephritis mediated by connective tissue growth factor derived from mesangial cells. PMID: 28191821
2. early myocardial CTGF mRNA expression (six hours) after Ang-II exposure is likely dependent on latent TGF-beta activation via the canonical Smad-dependent pathway in resident cardiac cells. PMID: 29575960
3. These results indicate that the hepatocytic expression of TGF-beta and CTGF is mediated by Wnt signalling in Schistosoma japonicum infection. PMID: 28331224
4. Data (including data from studies using transgenic mice) suggest that Ctgf secreted from vascular endothelium in pancreas plays critical role in up-regulation of insulin secretion in pancreatic beta-cells during pregnancy; here, pregnant mice with global Ctgf haplo-insufficiency (heterozygous for loss-of-function mutation) (a) exhibit impairment in maternal beta-cell proliferation and (b) develop gestational diabetes. PMID: 29111856
5. The data demonstrate that MMP13 and CTGF play a crucial role in modulation of fibrogenic mediators while promoting hepatic fibrogenesis. PMID: 28782260
6. p-SMAD2/3 and p-ERK1/2 might play a regulatory role in TGF-beta1 induced CTGF exp p-SMAD2/3 and p-ERK1/2 might play a regulatory role in TGF-beta1 induced CTGF expression during tooth development. PMID: 28825193
7. Ctgf is the direct target gene of SOX9 in chondrocytes and nucleus pulposus cells. PMID: 27436052
8. As shown in mouse model of kidney fibrosis CTGF is significantly involved in fibrosis-associated renal lymphangiogenesis through regulation of, and direct interaction with, VEGF-C. PMID: 28545716
9. this study suggested that CTGF antibody protected podocytes against injury in DN mice by reducing beta-catenin overexpression and preventing podocyte EMT, which might provide new insight into the mechanism of CTGF inhibition in the treatment of DN. PMID: 28370212
10. LPA-LPA1 signaling initiates profibrotic epithelial cell fibroblast communication mediated by epithelial cell derived connective tissue growth factor. PMID: 27927603
11. Down-regulation of CTGF is effective in inhibiting postoperative scarring in vivo. This suggests that RNAi with CTGF siRNA may potentially pave the road for a novel therapeutic strategy to improve glaucoma surgery results. PMID: 26554857
12. CTGF role in cardiac fibrosis. Long noncoding RNA H19 mediates CTGF expression. PMID: 28753062
13. Notch1 haploinsufficiency decreased the expression of Ctgf in the aorta and in vitro cell culture system. In vitro studies on SMCs using the Notch1 intracellular domain (NICD) plasmid, dominant negative mastermind-like (dnMAML), or specific siRNA suggest that Notch1, not Notch3, directly modulates the expression of CTGF PMID: 28562688
14. these findings show that cardiac ERK1/2 activity is modulated in part by TGF-b/Smad signaling, leading to altered activation of CTGF/CCN2 to mediate fibrosis and alter cardiac function. This identifies a novel mechanism in the development of LMNA cardiomyopathy. PMID: 27131347
15. the mechanistic target of rapamycin (mTOR) pathway in neurons regulates CTGF production and secretion, revealing a paracrine mechanism by which neuronal signaling regulates oligodendrocyte maturation and myelination in tuberous sclerosis complex (TSC). PMID: 28183733
16. CCN2 suppression by miR-199a-5p accounts, in part, for low-level fibrogenic gene expression in quiescent hepatic stellate cells (HSCs) and causes dampened gene expression in activated HSCs after horizontal transfer of miR-199a-5p in exosomes from quiescent HSCs. PMID: 27662798
17. Overexpression of CTGF in cardiomyocytes attenuates left ventricular hypertrophy in angiotensin II induced hypertension. PMID: 28287886
18. CTGF is overexpressed in gastric cancer and adjacent tissue compared to normal gastric tissue. Gastrin induces expression of CTGF in gastric epithelial cells. PMID: 27179776
19. These results indicate that tensile force induces in vivo gene expression associated with vascularization early in tensile-force-induced sutural bone formation. Moreover, the early induction of Vegf gene expression is regulated by CTGF and ROCK2. PMID: 26825658
20. these results suggested that loss of miR-30c may contribute to the pathogenesis of diabetic nephropathy (DN) by inhibiting target CTGF expression; replenishing miR-30c may ameliorate renal structure and function by reducing renal fibrosis in DN. PMID: 26775556
21. Data suggest that PTEN phosphatase (PTEN) regulates renal extracellular matrix production via activated protein kinase B (Akt) and increased connective tissue growth factor (CTGF) in diabetes mellitus. PMID: 26447680
22. Under physiological conditions, CCN2 may be regulating the levels of free amino acids in the extracellular matrix of cartilage. PMID: 26364758
23. These data indicate that LPA increases CCN2 expression through the activation of PKC and PKA. Thus, the regulatory functions of the PKC and PKA pathways are implicated in the LPA-induced increase in CCN2 expression PMID: 26743816
24. CTGF inhibition may benefit patients with dilated cardiomyopathy. PMID: 26549358
25. These results suggest that TGF-beta1 and CTGF may be involved in the process of denervated skeletal muscle fibrosis. PMID: 26686381
26. CCN genes are activated in heart failure. PMID: 25712640
27. CTGF knockout does not affect cardiac hypertrophy and fibrosis formation upon chronic pressure overload. PMID: 26410398
28. these findings reveal a key role of the SRF/CTGF/miR-133a axis in the regulation of cardiac fibrosis PMID: 26440278
29. Descriptive Statement Elimination of TGF-betaIIR is not sufficient to completely prevent liver fibrosis. TGF-beta-independent mechanism of type I collagen production and suggest connective tissue growth factor as its potent mediator. PMID: 25108224
30. CCN2 up regulation by tumor stromal cells is responsible for the melanoma metastasis. PMID: 26168233
31. CTGF siRNA ameliorates tubular cell apoptosis and tubulointerstitial fibrosis in obstructed mouse kidneys in a Sirt1-independent manner. PMID: 26257513
32. CTGF overexpression induces epithelial to mesenchymal transition in mouse primary AT II cells, which is mediated by ILK PMID: 25580742
33. Data suggest that, in mice with type 1 diabetes mellitus and diabetic nephropathy, up-regulation of urinary CTGF level is independently associated with biomarkers of proximal and distal tubular dysfunction and pathology. PMID: 26171399
34. Report showed that loss of PTEN expression resulted in collagen deposition in the lung in a CCN2-dependent manner supporting the notion that alterations in PTEN expression contribute to fibrogenesis and that CCN2 mediates collagen production in fibrosis. PMID: 25644104
35. knockdown of MRTF-A synthesis abolishes the systemic sclerosis myofibroblast enhanced basal contractility and synthesis of type I collagen and inhibits the matricellular profibrotic protein, connective tissue growth factor CCN2/CTGF PMID: 25955164
36. findings suggest CCN2 as a candidate of the fourth factor in the RANK/RANKL/OPG system for osteoclastogenesis, which regulates OPG and RANK via direct interaction PMID: 25554597
37. MRTF-A promotes microvessel growth (via CCN1) and maturation (via CCN2), thereby enabling functional improvement of ischaemic muscle tissue PMID: 24910328
38. CTGF reporter mice selectively identify a subpopulation of bone marrow mesenchymal progenitor cells that reside in the trabecular bone region. PMID: 25464947
39. Neither heart-specific Ctgf deletion nor CTGF overexpression altered cardiac remodeling and function with aging or after multiple acute stress stimuli. PMID: 25870108
40. This study provides a better understanding of the functions of connective tissue growth factor within the bone marrow, showing the dual regulatory role of the growth factor in skeletogenesis and in stage-specific B lymphopoiesis. PMID: 24727816
41. functional connection between CTGF and integrin alphavbeta6 during hepatic progenitor/oval cell activation and associated fibrosis PMID: 25203810
42. Ctgf is a target of Notch canonical signaling in osteoblasts, and may act in concert with Notch to regulate skeletal homeostasis PMID: 24792956
43. application of exogenous CCN2 protein caused ERK1/2 activation, and the neutralizing CCN2 antibody inhibited loading-induced ERK1/2 activation. PMID: 24155087
44. ET1 contributes to AF-dependent atrial fibrosis by synergistic activity with AngII to stimulate SGK1 expression and enhance phosphorylation of the SGK1 protein which, in turn, induces CTGF. PMID: 23414741
45. CTGF attenuates cardiac hypertrophy upon chronic pressure-overload due to inhibition of signaling mechanisms that promote pathologic myocardial hypertrophy. PMID: 23452880
46. CCN2 is packaged into secreted, nano-sized exosomes that mediate its intercellular transfer between hepatic stellate cells. PMID: 24882759
47. Transverse aortic constriction induced the cardiac expression of profibrotic connective tissue growth factor and attenuated the expression of SERCA2a (sarcoplasmic reticulum Ca2+-ATPase) in knockout mice PMID: 25027872
48. These findings uncover a novel functional role of CCN2 as a metabolic supporter in the growth-plate chondrocytes, which is required for skeletogenesis in mammals. PMID: 24288211
49. In a cardiomyocyte cell line, CTGF was secreted in response to cell stretching on a flexible membrane base (a cellular phenotype of cardiac diastolic dysfunction). PMID: 24464932
50. CCN2 expression by dermal papillae cells is a physiologically relevant suppressor of hair follicle formation by destabilization of beta-catenin and CCN2 normally acts to maintain stem cell quiescence. PMID: 24152728

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KEGG: mmu:14219

STRING: 10090.ENSMUSP00000020171

UniGene: Mm.390287