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  4. Recombinant Mouse C4b-binding protein (C4bpa)

Recombinant Mouse C4b-binding protein (C4bpa)

  • 货号：
    CSB-YP003951MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP003951MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP003951MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP003951MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP003951MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    C4bpa; C4bp; C4b-binding protein; C4bp
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    57-469
  • 氨基酸序列
    KCGP PPAIPNALPA SDVNRTDFES HTTLKYECLP GYGRGISRMM VYCKPSGEWE ISVSCAKKHC RNPGYLDNGY VNGETITFGS QIEFSCQEGF ILVGSSTSSC EVRGKGVAWS NPFPECVIVK CGPPPDISNG KHSGTEDFYP YNHGISYTCD PGFRLVGSPF IGCTVVNKTV PVWSSSPPTC EKIICSQPNI LHGVIVSGYK ATYTHRDSVR LACLNGTVLR GRHVIECQGN GNWSSLPTCE FDCDLPPAIV NGYYTSMVYS KITLVTYECD KGYRLVGKAI ISCSFSKWKG TAPQCKALCQ KPEVGNGTLS DEKDQYVESE NVTIQCDSGF AMLGSQSISC SESGTWYPEV PRCEQEASED LKPALTGNKT MQYVPNSHDV KMALEIYKLT LEVELLQLQI QKEKHTEAH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with serum amyloid P component.
  • 基因功能参考文献：
    1. Data suggest that C4bp prevents interaction between Tlr4/MD-2 and its ligand; C4bp does not appear to interact with Tlr3; C4bp binds to macrophage surface Tlr4 and inhibits Tlr/Tlr ligand interaction, thereby inhibiting Tlr4 activation. (C4bp = complement component 4 binding protein; Tlr = toll-like receptor; MD-2 = myeloid differentiation protein-2) PMID: 28542817
    2. this study shows that C4BP binds to TLR2, inhibits TLR1/2 ligand binding and reduces cytokine production PMID: 27794068
    3. These results suggest that EpC4BP is involved in male reproduction, but not essential for sperm maturation. PMID: 25468721
    4. a novel function of C4BP as an epididymal secretory protein PMID: 12930719
    5. findings show coagulation factor IX & complement component C4-binding protein can bind Adenovirus fiber knob domain & provide a bridge for virus uptake through cell surface heparan sulfate proteoglycans & low-density lipoprotein receptor-related protein PMID: 15919903
    6. C4BP prevents premature clearance of protein S and uses this ability to compensate the increased clearance of protein S-S460P. PMID: 16100035
    7. The cellular uptake of C4BP depends on both heparan sulfate proteoglycans and CD91, involving interactions with positively charged residues within C4BP alpha-chain. PMID: 18266273

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  • 亚细胞定位：
    Secreted.
  • 数据库链接：

    KEGG: mmu:12269

    STRING: 10090.ENSMUSP00000027657

    UniGene: Mm.306720