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  4. Recombinant Mouse Bone marrow stromal antigen 2 (Bst2), partial

Recombinant Mouse Bone marrow stromal antigen 2 (Bst2), partial

  • 中文名称：
    Recombinant Mouse Bone marrow stromal antigen 2(Bst2),partial,Yeast
  • 货号：
    CSB-YP819176MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Bone marrow stromal antigen 2(Bst2),partial,Yeast
  • 货号：
    CSB-EP819176MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Bone marrow stromal antigen 2(Bst2),partial,Yeast
  • 货号：
    CSB-EP819176MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Bone marrow stromal antigen 2(Bst2),partial,Yeast
  • 货号：
    CSB-BP819176MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Bone marrow stromal antigen 2(Bst2),partial,Yeast
  • 货号：
    CSB-MP819176MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Bst2
  • Uniprot No.：
  • 别名：
    Bst2Bone marrow stromal antigen 2; BST-2; HM1.24 antigen; CD antigen CD317
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1 (HIV-1), mouse mammary tumor virus (MMTV) and murine leukemia virus (MLV), filoviridae: ebola virus (EBOV), arenaviridae: lassa virus (LASV), and rhabdoviridae: vesicular stomatitis virus (VSV). Can inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration. Can stimulate signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection. Plays a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells.
  • 基因功能参考文献：
    1. contain the spread of herpes simplex virus type 1 in vivo, STING-dependent signaling leads to the upregulation of tetherin, a viral restriction factor PMID: 26627457
    2. Tetherin-mediated retention of R-defective virions on the cell surface could enhance syncytium formation. PMID: 27928916
    3. Bone marrow stromal antigen 2-mediated dendritic cell activation as a critical mechanism for how Tetherin influenced retrovirus cell-mediated immune responses that subsequently inhibited retrovirus replication in vivo. PMID: 26846717
    4. BST-2 does not have a role in modulating Influenza A Virus in the mouse model of infection PMID: 26566124
    5. Although Bst2 prevented Measles virus (MV) release from nonneuronal cells, its deletion had no effect on viral pathogenesis in MV-challenged mice. PMID: 26311886
    6. BST-2 contributes to the emergence of neoplasia and malignant progression of breast cancer. BST-2 enhances cancer cell adhesion, anchorage-independency, migration, and invasion. PMID: 25499888
    7. BST-2 protects lymphoid tissues from Chikungunya virus (CHIKV) infection and regulates CHIKV-induced inflammatory response by the host. PMID: 25053563
    8. TLR4 and PI3K effects on BST-2 induction are at the level of transcription. PMID: 24036213
    9. Tetherin acts as a modulator of the cell-mediated immune response against retrovirus infection in vivo. PMID: 24872193
    10. These findings suggest that BST2 antagonism by Vpu is critical for efficient early viral expansion and dissemination during acute infection and as such is likely to confer HIV-1 increased transmission fitness. PMID: 24195843
    11. These data suggest that overexpression of BST-2 in carcinoma tissues could not be attributed to interferons but to a yet to be determined factor that upregulates BST-2 once oncogenesis is initiated. PMID: 23806386
    12. Taken together, our results indicate that BST-2 is an important factor in the invasiveness and motility of tamoxifen-resistant breast cancer cells, and that its expression and activity are regulated by activated STAT3. PMID: 23702480
    13. BST-2 is a useful receptor to target with antigen, given its broad expression pattern and ability to access both MHCI and MHCII presentation pathways with relative efficiency. PMID: 23303646
    14. A single nucleotide polymorphism in tetherin promotes retrovirus restriction in vivo. PMID: 22457621
    15. find that tetherin markedly inhibits the replication of Moloney murine leukemia virus (Mo-MLV) and is required for the antiretroviral activity of IFNalpha to be fully manifested in vitro. PMID: 22025715
    16. These data provide evidence that BST-2 restricts mouse mammary tumor virus release from naturally infected cells and that BST-2 is an antiviral factor in vivo. PMID: 22284121
    17. These findings reflect involvement of BST2 in endocytosis and intracellular trafficking of viruses, viral nucleic acids, and Ags. PMID: 22327075
    18. Tetherin is expressed on the plasma membrane outer face of neuroblastoma cells, can be induced with both IFN-gamma & IFN-beta, & restricts progeny VSV release up to 100-fold, contributing to a potent antiviral state in the host cell. PMID: 21919738
    19. BST2-mediated Ag delivery in the presence of polyinosinic-polycytidylic acid as adjuvant induces cytotoxic T lymphocytes that are functional in vivo PMID: 21555533
    20. Structural and biophysical analysis of BST-2/tetherin ectodomains reveals an evolutionary conserved design to inhibit virus release. PMID: 21084286
    21. Elevated cellular levels of BST-2 inhibited the release of virus-like particles consisting of the matrix proteins of multiple highly virulent NIAID Priority Pathogens PMID: 20686043
    22. Targeting BST-2 with 2 independent monoclonal antibodies delayed lymphoma growth in a syngeneic mouse model of the disease. PMID: 19903902
    23. BST2 resides within an intracellular compartment corresponding to the Golgi apparatus, and may be involved in trafficking secreted cytokines in type I IFN-producing cells PMID: 16920966

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  • 亚细胞定位：
    Golgi apparatus, trans-Golgi network. Cell membrane; Single-pass type II membrane protein. Cell membrane; Lipid-anchor, GPI-anchor. Late endosome. Membrane raft. Cytoplasm. Apical cell membrane.
  • 组织特异性：
    In naive mice, specifically expressed on type I interferon-producing cells (at protein level).
  • 数据库链接：

    KEGG: mmu:69550

    STRING: 10090.ENSMUSP00000051921

    UniGene: Mm.260325