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  4. Recombinant Mouse Baculoviral IAP repeat-containing protein 7 (Birc7)

Recombinant Mouse Baculoviral IAP repeat-containing protein 7 (Birc7)

  • 中文名称：
    Recombinant Mouse Baculoviral IAP repeat-containing protein 7(Birc7),Yeast
  • 货号：
    CSB-YP002708MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Baculoviral IAP repeat-containing protein 7(Birc7),Yeast
  • 货号：
    CSB-EP002708MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Baculoviral IAP repeat-containing protein 7(Birc7),Yeast
  • 货号：
    CSB-EP002708MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Baculoviral IAP repeat-containing protein 7(Birc7),Yeast
  • 货号：
    CSB-BP002708MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Baculoviral IAP repeat-containing protein 7(Birc7),Yeast
  • 货号：
    CSB-MP002708MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Birc7
  • Uniprot No.：
  • 别名：
    Birc7; LivinBaculoviral IAP repeat-containing protein 7; EC 2.3.2.27; Livin; RING-type E3 ubiquitin transferase BIRC7) [Cleaved into: Baculoviral IAP repeat-containing protein 7 30 kDa subunit; Truncated livin; p30-Livin; tLivin)]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-285
  • 氨基酸序列
    MFSPADLFRA AVFSMGPESR ARDSVRGPEL SHREDGSGRT QEQDKPHCPC NHVLGQDCLD GQILGQLRPL SEEEESSGAA FLGEPAFPEM DSEDLRLASF YDWPSTAGIQ PEPLAAAGFF HTGQQDKVRC FFCYGGLQSW ERGDDPWTEH ARWFPRCQFL LRSKGRDFVE RIQTYTPLLG SWDQREEPED AVSATPSAPA HGSPELLRSR RETQPEDVSE PGAKDVQEQL RQLQEERRCK VCLDRAVSIV FVPCGHFVCT ECAPNLQLCP ICRVPICSCV RTFLS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of caspase-3, -7, and -9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1.
  • 基因功能参考文献：
    1. The overexpression of PTEN concomitant with Livin gene silencing was confirmed as a feasible and effective in vitro and in vivo gene modulation method, which may represent a potential therapeutic strategy for the treatment of Gastric Cancer. PMID: 29436592
    2. Data showed that Livin knock-down suppressed cell proliferation and inhibited cell invasion, accompanied by downregulation of VEGF and MMP-2/-9. Its silencing resulted in the prevention of xenograft tumor formation. PMID: 26094984
    3. Birc7 is a late fiber gene of the mouse lens. Its expression in cells bordering the OFZ is consistent with a role in organelle degradation, a process in which the ubiquitin proteasome pathway has been implicated previously. PMID: 26218911
    4. ML-IAP is dispensable for both normal mouse development and ocular homoeostasis. PMID: 22853455
  • 亚细胞定位：
    Nucleus. Cytoplasm. Golgi apparatus.
  • 蛋白家族：
    IAP family
  • 数据库链接：

    KEGG: mmu:329581

    STRING: 10090.ENSMUSP00000104503

    UniGene: Mm.187879