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  4. Recombinant Mouse Autophagy-related protein 16-2 (Atg16l2)

Recombinant Mouse Autophagy-related protein 16-2 (Atg16l2)

  • 货号：
    CSB-YP757138MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP757138MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP757138MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP757138MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP757138MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Atg16l2Autophagy-related protein 16-2; APG16-like 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-623
  • 氨基酸序列
    MAGPGAPCDP CAPAAVWKRH IVRQLRHRDR TQKALFLELV PAYNHLLEKA ELLAKFSEKL KSEPKDAIST RHEDWREEVS GTGPDQVSSP ASLRVKWQQE KKGLQLVCGE MAYQVVKKSA ALDTLQSQLE ERQDRLEALQ ACVVQLQEAR AQQSRQLEER QAENAAQREA YETLLQQAVH QEAALRRLQE EARDLLEQLV QRKARAAAER NLRNERRERA NQALVSQELK KAAKRTVSIS EIPNTLEDGT KEETVALAPA ALPEFSESET CEKWKRPFRS ASATSLTLSR CVDVVKGLLD FKKRRGHSVG GAPEQRYQSI PVCVSAQIPS QAQDVLDAHL SEVNAVCFGP NSSLLATGGA DRLIHLWNVV GGRLEANQTL EGAGGSITSV DFDPSGSQVL AATYNQAAQL WKVGETQSKE TLSGHKDKVT AAKFKLTRHQ AVTGSRDRTV KEWDLGRAYC SRTINVLSYC NDVVCGDHII ISGHNDQKIR FWDSRGPHCI QVIPVQGRVT SLHLSYDQLH LLSCSRDNTL KVIDLRISNI RQVFRADGFK CSSDWTKAVF SPDRSYALAG SSNGDLYIWD VNTGKLETSL QGPHCTAVNA VAWCFSGNHV VSVDQGRKVV LWH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play a role in regulating epithelial homeostasis in an ATG16L1-dependent manner.
  • 基因功能参考文献：
    1. IKKalpha, which may control autophagic protein degradation through its interaction with ATG16L2, plays a critical role in maintaining pancreatic acinar cell homeostasis, whose dysregulation promotes pancreatitis through p62 aggregate accumulation PMID: 23563314
    2. Despite forming the Atg12-Atg5-Atg16L2 complex, Atg16L2 is not recruited to phagophores and is mostly present in the cytosol. PMID: 22082872
  • 亚细胞定位：
    Cytoplasm, cytosol.
  • 蛋白家族：
    WD repeat ATG16 family
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    KEGG: mmu:73683

    STRING: 10090.ENSMUSP00000112500

    UniGene: Mm.275744