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  4. Recombinant Mouse Atrial natriuretic peptide receptor 1 (Npr1), partial

Recombinant Mouse Atrial natriuretic peptide receptor 1 (Npr1), partial

  • 货号：
    CSB-YP016023MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP016023MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP016023MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP016023MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP016023MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Npr1; NpraAtrial natriuretic peptide receptor 1; EC 4.6.1.2; Atrial natriuretic peptide receptor type A; ANP-A; ANPR-A; NPR-A; Guanylate cyclase A; GC-A
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.
  • 基因功能参考文献：
    1. A decreased Npr1 copy number enhanced the expression of hypertrophic markers. PMID: 27199456
    2. The results indicate that the inhibition of NPRA suppresses gastric cancer development and targeting NPRA may represent a promising strategy for the treatment of gastric cancer. PMID: 27634171
    3. KLF10 and atrial natriuretic peptide/NPRA in exerting influences on chronic pulmonary disease pathogenesis PMID: 27592451
    4. Treatment of the haplotype Npr1(+/-) mice with histone deacetylase inhibitors significantly lowered blood pressure and reduced the renal inflammation and fibrosis involving the interactive roles of HDAC1/2, NF-kappaB (p65), and STAT1. PMID: 28566502
    5. The results suggest that an antagonistic cascade exists between the TGF-beta1/Smad/deltaEF1 pathways and Npr1 expression and receptor signaling that is relevant to renal and vascular remodeling, and may be critical in the regulation of blood pressure and cardiovascular homeostasis. PMID: 26934489
    6. Conclude that postnatal cardiac hyperplasia in mice with global GC-A inactivation is provoked by systemic alterations rather than direct regulation of cardiac myocyte proliferation. PMID: 26059418
    7. Suggest that the FQQI motif is essential for the internalization and subcellular trafficking of NPRA during the hormone signaling process in intact mesangial cells. PMID: 26377794
    8. Data suggest activation of skeletal muscle (SM) Npra is important for maintenance of long-term insulin sensitivity; up-regulation of Npra signal transduction in SM (that was reduced by obesity) prevents glucose intolerance and diabetes type 2. PMID: 26253614
    9. these findings define a novel epigenetic regulatory mechanism that governs Npr1 gene transcription. PMID: 24451378
    10. Npr1 represses the expression of cardiac proinflammatory mediators, hypertrophic markers, and NF-kappaB/AP-1-mediated mechanisms, which seem to be associated in an Npr1 gene-dose-dependent manner PMID: 24424043
    11. ANP is capable of attenuating agonist-induced lung edema in the absence of NPR-A. PMID: 23195629
    12. These results demonstrate that a high-salt diet aggravates cardiac ANG II, aldosterone and pro-inflammatory cytokine levels in Npr1 gene-disrupted 1-copy mice, whereas, in Npr1 gene-duplicated (3-copy and 4-copy) mice, high salt did not render such elevation, suggesting the potential roles of Npr1 against salt loading. PMID: 23188418
    13. ANP-NPRA system exerts an inhibitory effect on MAPKs and down-stream effector molecules, AP-1, and CREB, critical for cell growth and proliferation. PMID: 22610792
    14. Natriuretic peptide receptor guanylyl cyclase-A protects podocytes from aldosterone-induced glomerular injury. PMID: 22652704
    15. Results demonstrate the opposite effects of NPR-A and NPR-C in LPS-mediated endothelial permeability and lung injury. PMID: 22001395
    16. Data suggest that a NPPA gradient originating in the oviduct induces sperm chemotaxis by binding to its receptor NPR1 and then activating PKG pathway, and plays a physiological role in fertilization. PMID: 21809340
    17. Cellular exposure to Go6976 reduced basal and natriuretic peptide-dependent, but not detergent-dependent, GC-A and GC-B activity. PMID: 21366551
    18. NPR-A regulates self-renewal and pluripotency of embryonic stem cells. PMID: 21390061
    19. Soluble guanylyl cyclase alpha1 subunit is important in penile erection in mice. PMID: 20098992
    20. The present results demonstrate that the disruption of Npr1 gene activates proinflammatory cytokines leading to fibrosis, hypertrophic growth, and remodeling of the kidneys of mutant mice. PMID: 20881240
    21. Trans retinoic acid activation of Npr1 gene transcription is mediated through binding of Ets-1 and Sp1 to the Npr1 promoter. PMID: 20864529
    22. Suggest that NPR-A activation by natriuretic peptides facilitates iNOS expression and contributes to the vascular dysfunction characteristic of endotoxic shock. PMID: 20649600
    23. results suggest that particulate matter and O3 exposures, alone and combined, lead to different cardiac functional changes, and these unique changes are age-specific and dependent on Nppa and Npr1 genes PMID: 20540624
    24. The ANP/GC-A system may have a modulating effect on beta-cell function. PMID: 20555029
    25. The Stria vascularis may be the most important place for ANP to regulate endolymph fluid balance via NPR-A. PMID: 20150880
    26. The ANP/NPR-A signaling pathway is upregulated in streptozotocin-induced diabetic mice, and contributes to the development of diabetic gastroparesis. PMID: 20039448
    27. Mice lacking a functional NPR-A receptor represent a useful model to study the role of the ANP system in alcohol-associated pathology. PMID: 19828462
    28. two distinct NPR-A phosphatase activities PMID: 11821394
    29. NPR1 is an atherosclerosis susceptibility locus and represents a potential link between atherosclerosis and cardiac hypertrophy. Npr1 has a role in regulation of hypertrophic cell growth. PMID: 12702516
    30. Results suggest a local function of the atrial natriuretic peptide receptor guanylyl cyclase-A system to moderate the molecular program of cardiac hypertrophy. PMID: 12727932
    31. NPRA activation is the predominant mechanism mediating the natriuretic, diuretic, and renal hemodynamic responses to acute blood volume expansion. PMID: 12824076
    32. NPRA receptor has a role in attenuating the effects of hypertrophic agents on cardiac wall thickness and in cardiac hypertrophy PMID: 14500707
    33. suggest that androgens contribute to gender-related differences in cardiac hypertrophy and fibrosis by a mechanism involving angiotensin II type 1A receptor (AT1A) receptors and guanylyl cyclase-A PMID: 14592959
    34. The combination of increased CaMKII activity and altered action potential characteristics facilitates ventricular arrhythmias in hypertrophic GC-A-/- hearts PMID: 15135664
    35. circulating ANP levels and data from NPR1(-/-) and NPR3(-/-) mice suggest that the ANP pathway may not be involved in the cardiovascular response to caloric restriction PMID: 15191892
    36. Acute renal and mean arterial pressure responses to atrial extracts require the NPRA receptor. PMID: 15337836
    37. ablation of NPRA/cGMP signaling activates NF-kappaB binding activity associated with hypertrophic growth of mutant mice hearts PMID: 15629436
    38. ATP does not activate NPRA and NPRB as has been repeatedly reported. Instead, ATP increases activity primarily by maintaining proper receptor phosphorylation status but also serves a previously unappreciated enzyme stabilizing function. PMID: 15911610
    39. Guanylyl cyclase-A activation by endogenous cardiac natriuretic peptides protects against acute heart failure and attenuates chronic cardiac remodeling after myocardial infarction, mediated partly through inhibition of renin-angiotensin system. PMID: 15998711
    40. Enhanced activity of the myocardial Na+/H+ exchanger NHE-1 moderates the cardiac growth response to pressure overload in atrial natriuretic peptide receptor-deficient mice. PMID: 16216978
    41. Ets-1 greatly stimulates Npr1 gene promoter activity, implicating its critical role in the regulation and function of NPRA at the molecular level PMID: 16517010
    42. ANG II-dependent transcriptional repression of Npr1 gene promoter activity and down-regulation of GC activity of translated protein, NPRA, is regulated by PKC pathways PMID: 16930545
    43. Reduced NPR-A protein levels, not receptor dephosphorylation, explain the renal hyporesponsiveness to natriuretic peptides in congestive heart failure. PMID: 17264312
    44. Findings provide direct evidence that ablation of NPRA/cGMP signaling activates inflammatory cytokines, probably via NF-kappaB mediated signaling pathway, and is associated with hypertrophic growth of null mutant hearts. PMID: 17267074
    45. Mediates cardiomegaly by its effect on two different gene pathways. PMID: 17293444
    46. increased adrenal ANG II and Aldo levels lead to renal and vascular injury in Npr1 gene-disrupted mice PMID: 17389676
    47. Disruption of NPRA/cGMP signaling leads to the augmented expression of cardiac renin-angiotensin pathways causing cardiac hypertrophy and remodeling. PMID: 17566078
    48. ATP is not required for the initial activation of natriuretic peptide receptor A and B, but does increase activity over time by reducing the apparent K(m) for GTP. PMID: 17848634
    49. These results suggest that NPRA is involved in tumor angiogenesis. PMID: 18172317
    50. Lung ischemia reperfuion injury triggers atrial natriuretic peptide release and alters endothelial signaling to activate NPR-A. PMID: 18223163

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Adenylyl cyclase class-4/guanylyl cyclase family
  • 数据库链接：

    KEGG: mmu:18160

    STRING: 10090.ENSMUSP00000029540

    UniGene: Mm.4627