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  4. Recombinant Mouse Angiogenic factor with G patch and FHA domains 1 (Aggf1)

Recombinant Mouse Angiogenic factor with G patch and FHA domains 1 (Aggf1)

  • 货号：
    CSB-YP001444MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP001444MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP001444MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP001444MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP001444MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Aggf1
  • Uniprot No.：
  • 别名：
    Aggf1; Vg5qAngiogenic factor with G patch and FHA domains 1; Angiogenic factor VG5Q; mVG5Q
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-711
  • 氨基酸序列
    ASEAPSPPS PSPPPPASPE PELAQLRRKV EKLERELRSC RRQVREVEKL LQHTERLYRN AESDNQELRT QVEELSKILH CGKNEDNPKS DVEVQTESQA PWAISDYYYQ TCYNDDSLPS KETELCVQQS QCAQASALDP QDESHIDSGS YAGADATEGV SHRQEDAVTS DSQESVSALA EGPALEGSSL AESLRAAAEA AVSQTGFTYD ESTGLYFDHS TGFYYDSENQ LYYDPSTGIY YYCDVESGRY QFHSRVDLQP YQTSSTKPNR ERRLKKRRKE PGFYTANEEK DLSSEDQKVC SVEYINCSED EHSGNVKKKA RTDTSHKSSP LQLTVAVSGD TVESPGDDNS ASSKDERIGE SESEPEEGEI TDSQSEKSYD GDSSSGDRET SEESDDEDEE RIWPPCIRVI VIRSPVLQMG SLFIITAVSP ATIGREKDME HTVRIPEVAV SKFHAEVYFD HDLQSYVLVD QGSQNGTIVN GKQILQPKTK CDPYVLEHGD EVKIGETVLS FHIHPGSETC DGCEPGQVRA HLRLDRKDEP LVGPALSKEE KELERRKALK KIRVKYGLQN TDYEAEKALK NPKYKDRAGK RREQVGSEGT FQRDDAPASV HSEITDSNKG RKMLEKMGWK RGEGLGKDGG GMKTPIQLQL RRTHAGLGTG KLSSIDDVHL IQNKSKKHWD KARERFAETF TENKPRKETP GAVPWVTGTA E
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion.
  • 基因功能参考文献：
    1. AGGF1 protein therapy is effective in blocking neointimal formation after vascular injury by regulating a novel AGGF1-MEK1/2-ERK1/2-Elk-myocardin-SRF/p27 signaling pathway. PMID: 28649088
    2. Together with recent identification of somatic mutations in p110a (encoded by PIK3CA), our data establish a potential mechanistic link between AGGF1 and PIK3CA, the two genes identified for Klippel-Trenaunay syndrome (KTS) PMID: 27522498
    3. Data indicate that angiogenic factor Aggf1+/- knockout (KO) mice show reduced autophagy, which was associated with inhibition of angiogenesis and larger infarct areas. PMID: 27513923
    4. Mechanistically, Aggf1 activated the expression of gluconeogenesis gene and skewed the insulin signaling pathway to induce insulin resistance. Taken together, our data suggest that Aggf1 plays a role in steatosis in vivo and as such may be a new target in the development of therapeutics solutions against steatosis. PMID: 27865839
    5. Sphingolipid modulation of angiogenic factor expression in neuroblastoma PMID: 21576349

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  • 亚细胞定位：
    Cytoplasm. Secreted.
  • 数据库链接：

    KEGG: mmu:66549

    STRING: 10090.ENSMUSP00000022189

    UniGene: Mm.36785