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  4. Recombinant Mouse Anamorsin (Ciapin1)

Recombinant Mouse Anamorsin (Ciapin1)

  • 货号：
    CSB-YP845140MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP845140MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP845140MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP845140MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP845140MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ciapin1
  • Uniprot No.：
  • 别名：
    Ciapin1Anamorsin; Cytokine-induced apoptosis inhibitor 1; Fe-S cluster assembly protein DRE2 homolog
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-309
  • 氨基酸序列
    MEEFGISPGQ LVAVFWDKSS PEEALKKLVA RLQELTGSEG QVFMENVTQL LQSSHKESSF DVILSGVVPG STSLHSAEVL AEMARILRPG GCLFLKEPVE TAEVNNDKMK TASKLCSALT LSGLVEIKEL QREALSPEEV QSVQEHLGYH SDSLRSVRVT GKKPNFEVGS SSQLKLPNKK SSSVKPVVDP AAAKLWTLSA NDMEDDSVDL IDSDELLDPE DLKRPDPASL KAPSCGEGKK RKACKNCTCG LAEELEREQS KAQSSQPKSA CGNCYLGDAF RCANCPYLGM PAFKPGEQVL LSNSNLQDA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells.
  • 基因功能参考文献：
    1. Among 46 putative substrates identified in MN9D neuronal cells, we further evaluated whether caspase-3-mediated cleavage of anamorsin, a recently recognized cell death-defying factor in hematopoiesis, is a general feature of apoptosis. PMID: 24973211
    2. AM was essential for both autonomous and extrinsic regulation of fetal liver hematopoiesis. This study provided new insight into the molecular regulation of hematopoiesis. PMID: 24440520
    3. play cooperatively essential roles in embryogenesis as iron-sulfur cluster proteins. PMID: 21513700
    4. These data suggest that PKCtheta;, PKCdelta, and p38MAPK activation lead to cell cycle retardation in AM KO MEF cells, and that AM may negatively regulate novel PKCs and p38MAPK in MEF cells. PMID: 21219862
    5. Anamorsin is considered to be a necessary molecule for hematopoiesis that mediates antiapoptotic effects of various cytokines. PMID: 14970183
    6. CIAPIN1 was localized in both the cytoplasm and the nucleus and was accumulated in the nucleolus. Bioinformatic prediction disclosed a putative nuclear localization signal and a putative nuclear export signal within mouse CIAPIN1. PMID: 16957168

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Mitochondrion intermembrane space.
  • 蛋白家族：
    Anamorsin family
  • 数据库链接：

    KEGG: mmu:109006

    STRING: 10090.ENSMUSP00000125451

    UniGene: Mm.27582