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  4. Recombinant Mouse Scinderin (Scin)

Recombinant Mouse Scinderin (Scin)

  • 货号：
    CSB-YP713881MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP713881MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP713881MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP713881MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP713881MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    ScinAdseverin; Gelsolin-like protein; Scinderin
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-715
  • 氨基酸序列
    MAQELQHPEF ARAGQQAGLQ VWRVEKLELV PVPQGAYGDF YVGDAYLVLH TTKSSRGFSY RLHFWLGKEC SQDESTAAAI FTVQMDDYLG GKPVQSRELQ GYESTDFVGY FKGGLKYKAG GVASGLNHVL TNDLTAKRLL HVKGRRVVRA TEVPLSWESF NKGDCFIIDL GTEIYQWCGS SCNKYERLKA SQVAIGIRDN ERKGRSQLIV VEEGSEPSEL MKVLGRKPEL PDGDNDDDVV ADISNRKMAK LYMVSDASGS MKVTLVAEEN PFSMGMLLSE ECFILDHGAA KQIFVWKGKN ANPQERKTAM KTAEEFLQKM KYSTNTQIQV LPEGGETPIF KQFFKDWKDK DQSDGFGKVY ITEKVAQIKQ IPFDASKLHS SPQMAAQHNM VDDGSGGVEI WRVENSGRVQ IDPSSYGEFY GGDCYIILYT YPRGQIIYTW QGANATRDEL TMSAFLTVQL DRSLGGQAVQ VRVSQGKEPA HLLSLFKDKP LIIYKNGTSK KEGQAPAPPT RLFQVRRNLA SITRIVEVDV DANSLNSNDT FVLKLPRNNG FIWIGKGASQ EEEKGAEYVA DVLKCKASRI QEGKEPEEFW NSLGGRGDYQ TSPLLETRAE DHPPRLYGCS NKTGRFIIEE VPGEFTQDDL AEDDVMLLDA WEQIFIWIGK DANEVEKKES VKSAKMYLET DPSGRDKRTP IVIIKQGHEP PTFTGWFLGW DSSRW
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2). In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles. Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts. Regulates chondrocyte proliferation and differentiation. Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways.; fails to nucleate actin polymerization, although it severs and caps actin filaments in a Ca(2+)-dependent manner.
  • 基因功能参考文献：
    1. indicate that in healthy, developing tissues, adseverin contributes to the regulation of osteoclast structure but not to bone metabolism in vivo PMID: 28389691
    2. Data indicate that adseverin (Ads) regulates actin cytoskeleton in osteoclasts. PMID: 25681458
    3. Ads is a RANKL induced early regulator of osteoclastogenesis with a potential role in pre-osteoclast differentiation and fusion. PMID: 25275604
    4. adseverin induction is a specific gene regulatory effect by TCDD on thymocytes. PMID: 11883943
    5. Overexpression of Scin is associated with asthma. PMID: 19028979

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Cell projection, podosome.
  • 蛋白家族：
    Villin/gelsolin family
  • 组织特异性：
    Ubiquitous. Highly expressed in mature osteoclasts (at protein level). Isoform 2 is expressed in blood cells.
  • 数据库链接：

    KEGG: mmu:20259

    STRING: 10090.ENSMUSP00000002640

    UniGene: Mm.2416