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  4. Recombinant Mouse Acrosin-binding protein (Acrbp)

Recombinant Mouse Acrosin-binding protein (Acrbp)

  • 货号：
    CSB-YP666299MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP666299MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP666299MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP666299MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP666299MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Acrbp
  • Uniprot No.：
  • 别名：
    AcrbpAcrosin-binding protein; Proacrosin-binding protein sp32
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    26-540
  • 氨基酸序列
    EESPA STPGSPLSST EYERFFALLT PTWKAETTCR LRATHGCRNP TLVQLDQYEN HGLVPDGAVC SDLPYASWFE SFCQFAQYRC SNHVYYAKRV RCSQPVSILS PNTLKEVESS AEVPPTSMTT PIVSHATATE HQAFQPWPER LNNNVEELLQ SSLSLGGKDQ QSSRRPGQEQ RKQEQIQEHK LEEAQEQEEQ EEEEEEEEAK QEEGQGTEAG LESVSRLQSD SEPKFQSQSL SSNPSFFTPR VREVESAPLM MKNIQELIRS AQEMDEMNEL YDDSWRSQST GSLQQLPHME TLMVLCYSIM ENTCTMTPTA KAWSYMEEEI LGFGDSVCDN LGRRHTAACP LCAFCSLKLE QCHSEASVLR QKCDASHKIP FISPLLSAQS ISTGNQARIP DKGRFAGLEM YGGLSSEFWC NRLAMKGCED DRVSNWLKAE FLSFQEGDFP TKICDTNYIQ YPNYCSFKSQ QCLLRNQNRK MSRMRCMLNE RYNVLSLAKS EEVILRWSQE FSTLAIGQFG
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acrosomal protein that maintains proacrosin (pro-ACR) as an enzymatically inactive zymogen in the acrosome. Involved also in the acrosome formation.; Maintains pro-ACR as an enzymatically inactive zymogen in the acrosome until acrosomal exocytosis. Partially contributes also to the assembly of acrosomal proteins to form an acrosomal granule.; Rodent specific isoform that participates in the formation of the acrosomal granule into the center of the acrosomal vesicle during early spermiogenesis. In the fertilization process promotes ACR release from the acrosome during acrosomal exocytosis.
  • 基因功能参考文献：
    1. ACRBP-null male mice showed a severely reduced fertility, because of malformation of the acrosome. PMID: 27303034
    2. Two forms of Acrbp mRNA-wild-type Acrbp-W and variant Acrbp-V5 mRNAs-were generated by alternative splicing of Acrbp in the mouse. PMID: 23426433
    3. Data suggest that the fertility defect in PCSK4 (proprotein convertase subtilisin/kexin type 4) knockout mice is due, in part, to altered processing/proteolysis of ACRBP as well as structural abnormalities in sperm heads and acrosomes. PMID: 22357636
  • 亚细胞定位：
    [Isoform 2]: Cytoplasmic vesicle, secretory vesicle, acrosome.; [Isoform 1]: Cytoplasmic vesicle, secretory vesicle, acrosome. Secreted.
  • 组织特异性：
    [Isoform 1]: Testis-specific (at protein level). Detected in pachytene spermatocytes and in haploid spermatids and in elongating spermatids.; [Isoform 2]: Testis-specific. Detected in pachytene spermatocytes and round spermatids but absent in elongating s
  • 数据库链接：

    KEGG: mmu:54137

    STRING: 10090.ENSMUSP00000085632

    UniGene: Mm.347910