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  4. Recombinant Mouse Acidic leucine-rich nuclear phosphoprotein 32 family member A (Anp32a)

Recombinant Mouse Acidic leucine-rich nuclear phosphoprotein 32 family member A (Anp32a)

  • 中文名称：
    Recombinant Mouse Acidic leucine-rich nuclear phosphoprotein 32 family member A(Anp32a),Yeast
  • 货号：
    CSB-YP001822MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Acidic leucine-rich nuclear phosphoprotein 32 family member A(Anp32a),Yeast
  • 货号：
    CSB-EP001822MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Acidic leucine-rich nuclear phosphoprotein 32 family member A(Anp32a),Yeast
  • 货号：
    CSB-EP001822MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Acidic leucine-rich nuclear phosphoprotein 32 family member A(Anp32a),Yeast
  • 货号：
    CSB-BP001822MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Acidic leucine-rich nuclear phosphoprotein 32 family member A(Anp32a),Yeast
  • 货号：
    CSB-MP001822MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Anp32a
  • Uniprot No.：
  • 别名：
    Anp32a; Anp32; Lanp; Acidic leucine-rich nuclear phosphoprotein 32 family member A; Acidic nuclear phosphoprotein pp32; Leucine-rich acidic nuclear protein; LANP; Potent heat-stable protein phosphatase 2A inhibitor I1PP2A
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-247
  • 氨基酸序列
    MEMDKRIYLE LRNRTPSDVK ELVLDNCKSI EGKIEGLTDE FEELEFLSTI NVGLTSISNL PKLNKLKKLE LSENRISGDL EVLAEKCPNL KHLNLSGNKI KDLSTIEPLK KLENLKSLDL FNCEVTNLNA YRENVFKLLP QVMYLDGYDR DNKEAPDSDV EGYVEDDDEE DEDEEEYDEY AQLVEDEEEE DEEEEGEEED VSGEEEEDEE GYNDGEVDDE EDEEEAGEEE GSQKRKREPD DEGEEDD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Multifunctional protein that is involved in the regulation of many processes including tumor suppression, apoptosis, cell cycle progression or transcription. Promotes apoptosis by favouring the activation of caspase-9/CASP9 and allowing apoptosome formation. In addition, plays a role in the modulation of histone acetylation and transcription as part of the INHAT (inhibitor of histone acetyltransferases) complex. Inhibits the histone-acetyltranferase activity of EP300/CREBBP (CREB-binding protein) and EP300/CREBBP-associated factor by histone masking. Preferentially binds to unmodified histone H3 and sterically inhibiting its acetylation and phosphorylation leading to cell growth inhibition. Participates in other biochemical processes such as regulation of mRNA nuclear-to-cytoplasmic translocation and stability by its association with ELAVL1 (Hu-antigen R). Plays a role in E4F1-mediated transcriptional repression as well as inhibition of protein phosphatase 2A.
  • 基因功能参考文献：
    1. our study reveals that ANP32A dysregulation may be a critical factor contributing to acute megakaryoblastic leukemia PMID: 29269781
    2. We conclude that downregulating ANP32A rescues synaptic plasticity and memory ability by reducing INHAT formation and unmasking histone for hyperacetylation PMID: 28472990
    3. The variation of expression levels and distribution of ANP32A in the developing brain would imply that ANP32A may play an important role in mammalian brain development PMID: 25866766
    4. depleting the Leucine-rich Acidic Nuclear Protein (LANP)-an ATXN1 binding inhibitor of histone acetylation-reverses aspects of Spinocerebellar ataxia type 1 neuritic pathology. PMID: 22884877
    5. Regulation of histone acetylation and transcription by nuclear protein pp32, a subunit of the INHAT complex. PMID: 11830591
    6. Results show that leucine-rich acidic nuclear protein (LANP)-null mice are viable and fertile, and point to a functional redundancy of LANP's function, most likely provided by its closely related family members. PMID: 15060138
    7. Results describe the solution structure of the evolutionarily conserved N-terminal leucine-rich repeat (LRR) domain of Anp32a and model its interactions with other proteins. PMID: 18410380
    8. PHAPI/pp32 suppresses tumorigenesis by stimulating apoptosis. PMID: 19121999
    9. LANP directly regulates expression of the neurofilament light chain, an important neuron-specific cytoskeletal gene, by binding to the promoter of this gene and modulating histone acetylation levels PMID: 19136565

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Endoplasmic reticulum. Note=Shuttles between nucleus and cytoplasm. Translocates to the cytoplasm during the process of neuritogenesis.
  • 蛋白家族：
    ANP32 family
  • 组织特异性：
    Predominantly expressed in the cerebellum. Expressed also in cortex, lung, skeletal muscle, gastrointestinal tract, spleen, liver and heart.
  • 数据库链接：

    KEGG: mmu:11737

    STRING: 10090.ENSMUSP00000082652

    UniGene: Mm.269088