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  4. Recombinant Mouse AH receptor-interacting protein (Aip)

Recombinant Mouse AH receptor-interacting protein (Aip)

  • 货号：
    CSB-YP522511MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP522511MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP522511MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP522511MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP522511MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Aip
  • Uniprot No.：
  • 别名：
    Aip; AH receptor-interacting protein; AIP; Aryl-hydrocarbon receptor-interacting protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-330
  • 氨基酸序列
    MADLIARLRE DGIQKRVIQE GRGELPDFQD GTKATFHFRT LHSDNEGSVI DDSRTRGKPM ELIVGKKFKL PVWETIVCTM REGEIAQFLC DIKHVVLYPL VAKSLRNIAE GKDPLEGQRH CCGIAQMHEH SSLGHADLDA LQQNPQPLIF HIEMLKVESP GTYQQDPWAM TDEEKAKAVP VIHQEGNRLY REGQVKEAAA KYYDAIACLK NLQMKEQPGS PDWIQLDLQI TPLLLNYCQC KLVAQEYYEV LDHCSSILNK YDDNVKAYFK RGKAHAAVWN AQEAQADFAK VLELDPALAP VVSRELRALE TRIRQKDEED KARFRGIFSH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.
  • 基因功能参考文献：
    1. Results demonstrated that Aip inactivation promoted somatotroph tumorigenesis and overproduction of growth hormone probably through increased Stat3 activation. PMID: 27706259
    2. Results provide novel evidence that AIP has an important role in the regulation of cAMP synthesis. PMID: 24662816
    3. XAP2 exerts a negative effect on ERalpha transcriptional activity and may thus prevent ERalpha-dependent events. PMID: 21984905
    4. Developmental control of apoptosis by the immunophilin aryl hydrocarbon receptor-interacting protein (AIP) involves mitochondrial import of the survivin protein PMID: 21454573
    5. Mice with inactivation of aryl hydrocarbon receptor-interacting protein display complete penetrance of pituitary adenomas with aberrant ARNT expression. PMID: 20709796
    6. Data show that AIP is not required for the induction of the Cyp1a1 and Cyp1a2 genes. PMID: 20829355
    7. XAP2 hinders importin beta binding to the mAhR complex and represses the transactivation potential of the AhR by stabilizing the receptor complex and/or blocking nucleocytoplasmic shuttling of the AhR complex PMID: 12431985
    8. PPARalpha is in a complex with hsp90 and XAP2, and XAP2 appears to function as a repressor PMID: 12482853
    9. XAP2 has a role in stabilization of the dioxin receptor PMID: 12837759
    10. The role of Xap2 and C-terminal hsp-70 interacting protein on the endogenous Ah receptors expressed in mouse cell lines was determined. PMID: 16085934
    11. the role of ARA9 in cardiac development is independent of its interactions with its known xenobiotic receptor partners. PMID: 17916558
    12. expression level of ARA9 correlates with the frequency of a phenocopy of the Ahr-null allele supports the conclusion that the ARA9 protein is essential for AHR signaling during development PMID: 18669605
    13. XAP2 affects triiodothyronine-transcriptional repression of the hypothalamic gene, throtropin releasing hormone. PMID: 18679634

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  • 亚细胞定位：
    Cytoplasm.
  • 数据库链接：

    KEGG: mmu:11632

    STRING: 10090.ENSMUSP00000025767

    UniGene: Mm.10433