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  4. Recombinant Influenza B virus Non-structural protein 1 (NS)

Recombinant Influenza B virus Non-structural protein 1 (NS)

  • 货号：
    CSB-YP365963IJK
  • 规格：
    ￥2208
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
      The reducing (R) protein migrates as 45 kDa in SDS-PAGE may be due to glycosylation.
  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
    NS
  • Uniprot No.：
  • 别名：
    NS; Non-structural protein 1; NS1; NS1A
  • 种属：
    Influenza B virus (strain B/Lee/1940)
  • 蛋白长度：
    Full Length
  • 来源：
    Yeast
  • 分子量：
    34.1 kDa
  • 表达区域：
    1-281aa
  • 氨基酸序列
    MADNMTTTQIEVGPGATNATINFEAGILECYERFSWQRALDYPGQDRLHRLKRKLESRIKTHNKSEPENKRMSLEERKAIGVKMMKVLLFMDPSAGIEGFEPYCVKNPSTSKCPNYDWTDYPPTPGKYLDDIEEEPENVDHPIEVVLRDMNNKDARQKIKDEVNTQKEGKFRLTIKRDIRNVLSLRVLVNGTFLKHPNGDKSLSTLHRLNAYDQNGGLVAKLVATDDRTVEDEKDGHRILNSLFERFDEGHSKPIRAAETAVGVLSQFGQEHRLSPEEGDN
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds and inhibits the conjugation of the ubiquitin-like G1P2/ISG15 protein to its target proteins. Since G1P2/ISG15 is an early antiviral protein, NS1 may inhibit the host antiviral response. Prevents EIF2AK2/PKR activation, either by binding double strand RNA or by interacting directly with EIF2AK2/PKR. Also binds poly(A) and U6 snRNA.
  • 基因功能参考文献：
    1. Here using a recombinant virus encoding a NS1B protein defective in ISG15 binding, the s show that NS1B counteracts ISGylation-mediated antiviral activity by binding and sequestering ISGylated viral proteins, primarily ISGylated viral nucleoprotein, in infected cells. PMID: 27587337
    2. The novel RNA-binding site of NS1B is required for optimal influenza B virus replication and is absent from influenza A viruses. PMID: 27545620
    3. Glycine substitutions of the SH3-BM (aa 122-127) within NS1 protein lead to enhanced viral replication in human cells. PMID: 27654951
  • 亚细胞定位：
    Host cytoplasm. Host nucleus.
  • 蛋白家族：
    Influenza B viruses NS1 family
  • 数据库链接：

    KEGG: vg:26824008