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  4. Recombinant Human herpesvirus 1 Tegument protein VP22 (UL49)

Recombinant Human herpesvirus 1 Tegument protein VP22 (UL49)

  • 货号：
    CSB-YP319874HWY
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP319874HWY
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP319874HWY-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP319874HWY
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP319874HWY
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    UL49
  • Uniprot No.：
  • 别名：
    UL49; Tegument protein VP22
  • 种属：
    Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-301
  • 氨基酸序列
    MTSRRSVKSG PREVPRDEYE DLYYTPSSGM ASPDSPPDTS RRGALQTRSR QRGEVRFVQY DESDYALYGG SSSEDDEHPE VPRTRRPVSG AVLSGPGPAR APPPPAGSGG AGRTPTTAPR APRTQRVATK APAAPAAETT RGRKSAQPES AALPDAPAST APTRSKTPAQ GLARKLHFST APPNPDAPWT PRVAGFNKRV FCAAVGRLAA MHARMAAVQL WDMSRPRTDE DLNELLGITT IRVTVCEGKN LLQRANELVN PDVVQDVDAA TATRGRSAAS RPTERPRAPA RSASRPRRPV E
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Tegument protein that plays different roles during the time course of infection. Participates in both the accumulation of viral mRNAs and viral protein translation at late time of infection. Modulates the RNase activity of the virion host shutoff protein UL41 probably to ensure necessary levels of key cellular mRNAs and proteins. Plays a role in microtubule reorganization that occurs after viral infection by stabilizing microtubule network. Finally, may prevent nucleosomal deposition onto the viral genome by interacting with and inhibiting host SET.
  • 基因功能参考文献：
    1. herpes simplex virus 1 tegument protein VP22 inhibits AIM2-dependent inflammasome activation. VP22 interacts with AIM2 and prevents its oligomerization, an initial step in AIM2 inflammasome activation. PMID: 29447697
    2. findings indicate that HSV-1 VP22 acts as an antagonist of IFN signaling to persistently evade host innate antiviral responses. PMID: 29793952
    3. These findings suggest that VP22 is required (but not sufficient) for the inhibition of CD1d-mediated antigen presentation in herpes simplex virus type 1 infection. PMID: 27327902
    4. The s have determined the crystal structure of the conserved core domain of VP22, which reveals an elongated dimer with several potential protein-protein interaction regions and a peptide-binding site. PMID: 26068188
    5. HSV-1 VP22 is a significant neurovirulence factor in vivo. PMID: 22357273
    6. while RNF10 and WDR42A or VP22 alone showed distinct subcellular localization patterns, RNF10 and WDR42A were relocated when co-expressed with VP22 or its homologues; these potential host cell factors of VP22 might expand the list of host targets of VP22 PMID: 21424732
    7. We have identified an interaction between VP22, an abundant tegument protein and the cytoplasmic tail of glycoprotein E (gE). PMID: 16997344
    8. nexpression of the UL41 vhs protein in the absence of U(L)49 protein is lethal. PMID: 17670820
    9. VP22 can easily transport between different cells but nuclear accumulation of the protein is not common in all of the recipient cells. PMID: 18051705
    10. The s conclude that nuclear VP22 targets unique subnuclear structures early (<6hpi) during herpes simplex virus 1 (HSV-1) infection. PMID: 18584907
    11. VP22 was required for optimal synthesis of the late viral proteins gE and gD and the immediate-early protein ICP0 but did not have discernible effects on accumulation of the immediate-early proteins ICP4 or ICP27. PMID: 18987147
    12. role of the tegument protein VP22 in viral replication PMID: 18989638
    13. Small mutations within the gE binding domain of VP22 inhibit the VP22-gE interaction in infected cells. PMID: 19279114
    14. These results indicate that the last fifteen amino acids of VP22 participate in virion targeting during HSV-1 infection. PMID: 19307008

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  • 亚细胞定位：
    Virion tegument. Host cytoplasm. Host nucleus. Host Golgi apparatus. Note=One of the most abundant tegument protein (about 2000 copies per virion). Localizes in the cytoplasm at 8 hours postinfection and in the nucleus at 16 hours postinfection. During virion morphogenesis, this protein probably accumulates at the trans-Golgi where secondary envelopment occurs.
  • 蛋白家族：
    Alphaherpesvirinae VP22 tegument protein family
  • 数据库链接：

    KEGG: vg:2703417