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  4. Recombinant Human adenovirus C serotype 2 Probable early E4 11 kDa protein

Recombinant Human adenovirus C serotype 2 Probable early E4 11 kDa protein

  • 中文名称：
    Recombinant Human adenovirus C serotype 2 Probable early E4 11 kDa protein,Yeast
  • 货号：
    CSB-YP360997HIK
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human adenovirus C serotype 2 Probable early E4 11 kDa protein,Yeast
  • 货号：
    CSB-EP360997HIK
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human adenovirus C serotype 2 Probable early E4 11 kDa protein,Yeast
  • 货号：
    CSB-EP360997HIK-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human adenovirus C serotype 2 Probable early E4 11 kDa protein,Yeast
  • 货号：
    CSB-BP360997HIK
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human adenovirus C serotype 2 Probable early E4 11 kDa protein,Yeast
  • 货号：
    CSB-MP360997HIK
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    N/A
  • Uniprot No.：
  • 别名：
    Early 4 ORF3 protein; E4-ORF3; E4 ORF3 control protein; Early 4 11 kDa protein; E4-11k
  • 种属：
    Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-116
  • 氨基酸序列
    MIRCLRLKVE GALEQIFTMA GLNIRDLLRD ILIRWRDENY LGMVEGAGMF IEEIHPEGFS LYVHLDVRAV CLLEAIVQHL TNAIICSLAV EFDHATGGER VHLIDLHFEV LDNLLE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Forms a multivalent network in host nucleus that inhibits nuclear bodies and prevents antiviral cellular activities. The network is made of multimerized dimers and surrounds adenovirus replication centers and nucleolus. Plays a role in splicing of the major late transcript. Prevents viral genome concatemer formation.
  • 基因功能参考文献：
    1. The ability of E4-ORF3 to manipulate cellular gene expression through the sequestration of cellular proteins implicates a novel role for E4-ORF3 in transcriptional regulation. PMID: 25984715
    2. The adenoviral E4orf3 protein facilitates exit from mitosis, possibly by altering the intracellular distribution of cyclin B1. PMID: 25694601
    3. The absence of the E4 Orf3 protein increased expression of several p53-responsive genes when the E1B protein was also absent from infected cells. PMID: 25568206
    4. These findings demonstrated a role for the human adenovirus E4-ORF3 protein as a regulator of ubiquitin-like modifications and revealed new SUMO3 substrates induced by E4-ORF3. PMID: 25410875
    5. These data show for first time that adenovirus type 5 E4orf4 interacts with and modifies the nuclear pore complex and that Nup205-E4orf4 binding is required for normal regulation of viral gene expression and viral replication. PMID: 25210169
    6. Adenovirus E4orf4 protein-induced death of p53-/- cancer cells follows a G1 arrest of both tetraploid and diploid cells. PMID: 24067978
    7. Adenovirus E4orf3 targets TIF1 gamma for proteasome-dependent degradation during infection. PMID: 22205733

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  • 亚细胞定位：
    Host nucleus. Note=forms networks in the nucleus that may surround adenovirus replication centers.
  • 蛋白家族：
    Adenoviridae E4 ORF3 family