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  4. Recombinant Human Zinc transporter 5 (SLC30A5), partial

Recombinant Human Zinc transporter 5 (SLC30A5), partial

  • 中文名称：
    人SLC30A5重组蛋白
  • 货号：
    CSB-YP823441HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SLC30A5重组蛋白
  • 货号：
    CSB-EP823441HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SLC30A5重组蛋白
  • 货号：
    CSB-EP823441HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SLC30A5重组蛋白
  • 货号：
    CSB-BP823441HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SLC30A5重组蛋白
  • 货号：
    CSB-MP823441HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SLC30A5
  • Uniprot No.：
  • 别名：
    SLC30A5; ZNT5; ZNTL1; ZTL1; UNQ863/PRO1879Zinc transporter 5; ZnT-5; Solute carrier family 30 member 5; ZnT-like transporter 1; hZTL1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Functions as a zinc transporter. May be a transporter of zinc into beta cells in order to form insulin crystals. Partly regulates cellular zinc homeostasis. Required with ZNT7 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT6 and ZNT7 for the activation of TNAP.
  • 基因功能参考文献：
    1. There was a significant increase in protein levels of ZnT5 in the prefrontal cortex in Major depression disorder, relative to control subjects. PMID: 27661418
    2. Overexpression of ZnT5 is accompanied by activation of PI3K/Akt pathway and inhibiting HG-induced apoptosis. PMID: 23275032
    3. Results identify a unique class of transporters Znt5 and Znt8 and the structural motif required to discriminate between Zn(2+) and Cd(2+) transport. PMID: 22529353
    4. exons 15 to 17 include a signal that results in trafficking of ZnT5 to the Golgi apparatus and that the 3' end of exon 14 includes a signal that leads to retention in the ER. PMID: 21887337
    5. cloning and characterization of ZnT-5 which is expressed in pancreatic beta cells PMID: 11904301
    6. A novel zinc-regulated human zinc transporter, hZTL1, is localized to the enterocyte apical membrane PMID: 11937503
    7. hZnT-5 is up-regulated in response to cellular zinc depletion in Raji cells. PMID: 17971500
    8. Data show that ZNT5 is extensively present in the Abeta-positive plaques in the cortex of human AD brains. PMID: 18639746

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  • 亚细胞定位：
    Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Perimeter of granules, localizes to the brush border membrane of the enterocyte. Concentrated in early compartments of the secretory pathway such as COPII-coated vesicles.
  • 蛋白家族：
    Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family, SLC30A subfamily
  • 组织特异性：
    Ubiquitously expressed. Highly expressed in pancreas, liver and kidney. Expressed abundantly in insulin-containing beta cells, undetectable in other endocrine cell types including glucagon-secreting alpha cells and most acinar cells.
  • 数据库链接：

    HGNC: 19089

    OMIM: 607819

    KEGG: hsa:64924

    STRING: 9606.ENSP00000379836

    UniGene: Hs.631975