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  4. Recombinant Human Zinc finger protein 582 (ZNF582)

Recombinant Human Zinc finger protein 582 (ZNF582)

  • 货号：
    CSB-YP026864HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP026864HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP026864HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP026864HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP026864HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ZNF582
  • Uniprot No.：
  • 别名：
    Zinc finger protein 582; ZN582_HUMAN; ZNF 582; ZNF582
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-517
  • 氨基酸序列
    MSLGSELFRD VAIVFSQEEW QWLAPAQRDL YRDVMLETYS NLVSLGLAVS KPDVISFLEQ GKEPWMVERV VSGGLCPVLE SRYDTKELFP KQHVYEVESP QWEIMESLTS YGLECSSFQD DWECRNQFDR QQGNPDRHFH QMIIRHEEMP TFDQHASLTF YQKIHTREKP FGYNKCRKDF WQKELLINHQ GIYTNEKPYK CKECGKAFKY GSRLIQHENI HSGKKPYECK ECGKAFNSGS NFIQHQRVHT GEKPYECKDC EKAFSRSSQL IEHQRTHTGE KPYQCKECGK AFNRISHLKV HYRIHTGEKP YACKECGKTF SHRSQLIQHQ TVHTGRKLYE CKECGKAFNQ GSTLIRHQRI HTGEKPYECK VCGKAFRVSS QLKQHQRIHT GEKPYQCKVC GRAFKRVSHL TVHYRIHTGE KPYECKECGK AFSHCSQLIH HQVIHTEKKP YEYKECEKTL SHDSTTVQPQ RMHNRETHVN IINVEKPSIS SYPLLIIREF MLASNHMNGS NGESPLA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be involved in transcriptional regulation.
  • 基因功能参考文献：
    1. Hypermethylated ZNF582 and PAX1 genes in the oral scrapings collected from adjacent normal oral mucosal sites rather than cancer sites are associated with aggressive progression and poor prognosis of OSCC PMID: 29224816
    2. conclude that hypermethylated ZNF582 and PAX1 are effective biomarkers for the detection of oral dysplasia and oral cancer and for the prediction of oral cancer recurrence PMID: 27865370
    3. DNA methylation status of ZNF582 showed a relatively good sensitivity and specificity for the detection of ESOPHAGEAL SQUAMOUS CELL CARCINOMA. PMID: 28241446
    4. Results show that promoter hypermethylation of ADCY8, CDH8, and ZNF582 are correlated with high-grade squamous intraepithelial lesion. PMID: 27651839
    5. This is the first study to show that ZNF582 methylation analysis of cervical swabs may be a promising choice in the positive triage of cytological diagnoses of low-grade squamous intraepithelial lesions PMID: 25134998
    6. Methylation levels of ZNF582 in uterine cervix adenocarcinomas is significantly higher than those in normal cervical tissues. PMID: 24407576
    7. ZNF582 is frequently methylated in cervical intraepithelial neoplasia 3 and worse lesions PMID: 22815913

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family
  • 数据库链接：

    HGNC: 26421

    OMIM: 615600

    KEGG: hsa:147948

    STRING: 9606.ENSP00000301310

    UniGene: Hs.244391