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  4. Recombinant Human Zinc finger matrin-type protein 3 (ZMAT3)

Recombinant Human Zinc finger matrin-type protein 3 (ZMAT3)

  • 中文名称：
    人ZMAT3重组蛋白
  • 货号：
    CSB-YP862051HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人ZMAT3重组蛋白
  • 货号：
    CSB-EP862051HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人ZMAT3重组蛋白
  • 货号：
    CSB-EP862051HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人ZMAT3重组蛋白
  • 货号：
    CSB-BP862051HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人ZMAT3重组蛋白
  • 货号：
    CSB-MP862051HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    FLJ12296; FLJ31683; MGC10613; OTTHUMP00000211906; OTTHUMP00000211907; p53 activated gene 608; p53 inducible zinc finger protein; p53 target zinc finger protein; p53-activated gene 608 protein; PAG 608; WIG 1; WIG 1/PAG608 protein; WIG1; WIG1/PAG608 protein; Wildtype p53-induced gene; Zinc finger matrin type 3; Zinc finger matrin-type protein 3; Zinc finger protein WIG 1; Zinc finger protein WIG-1; Zinc finger protein WIG1; ZMAT 3; Zmat3; ZMAT3_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-289
  • 氨基酸序列
    MILLQHAVLP PPKQPSPSPP MSVATRSTGT LQLPPQKPFG QEASLPLAGE EELSKGGEQD CALEELCKPL YCKLCNVTLN SAQQAQAHYQ GKNHGKKLRN YYAANSCPPP ARMSNVVEPA ATPVVPVPPQ MGSFKPGGRV ILATENDYCK LCDASFSSPA VAQAHYQGKN HAKRLRLAEA QSNSFSESSE LGQRRARKEG NEFKMMPNRR NMYTVQNNSA GPYFNPRSRQ RIPRDLAMCV TPSGQFYCSM CNVGAGEEME FRQHLESKQH KSKVSEQRYR NEMENLGYV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a bona fide target gene of p53/TP53. May play a role in the TP53-dependent growth regulatory pathway. May contribute to TP53-mediated apoptosis by regulation of TP53 expression and translocation to the nucleus and nucleolus.
  • 基因功能参考文献：
    1. WIG1 governs the miRNA-dependent and the miRNA-independent recruitment of AGO2 to lower the stability of and suppress the translation of ACOT7 mRNA. PMID: 28472401
    2. we propose that Wig1, a key p53 downstream molecule in HD condition, play an important role in stabilizing mutant Htt mRNA and thereby accelerating HD pathology in the mHtt-p53-Wig1 positive feedback manner PMID: 27206983
    3. expression of the p53 target Wig-1 is associated with HPV status and patient survival in cervical carcinoma PMID: 25379706
    4. Results suggest a role of Wig-1 as a survival factor that directs the p53 stress response toward cell cycle arrest rather than apoptosis through the regulation of FAS and 14-3-3sigma mRNA levels. PMID: 24469038
    5. PSF and MATR3 are cellular host factors that bind viral RNA and promote Rev activity. PMID: 23158102
    6. The data indicated a novel role for Wig1 in RNA-induced silencing complex target accessibility, which is a key step in RNA-mediated gene silencing. Fine tuning of p21 levels by Wig1 was essential for the prevention of cellular senescence. PMID: 23085987
    7. Wig-1 knockdown causes a dramatic inhibition of N-Myc expression and triggers differentiation in neuroblastoma cells carrying amplified N-Myc. PMID: 22513872
    8. WIG-1 might be involved in the zinc-induced cell cycle arrest and apoptosis of human esophageal squamous cell carcinoma cells PMID: 21559779
    9. WIG-1 might be a novel modifier in esophageal carcinogenesis, and the WIG-1 MAb should be useful in further study of the mechanism in WIG-1-related physiological reactions. PMID: 21050045
    10. The cellular distribution of the nuclear matrix protein matrin 3 is altered by novel phosphorylation induced by the alphaherpesvirus US3 kinase family. PMID: 20962082
    11. Results demonstrate that human Wig-1 can bind different types of double-stranded RNAs (dsRNAs), including dsRNAs resembling small interfering RNAs and microRNAs, and indicate that dsRNA binding has a role in Wig-1-mediated regulation of cell growth. PMID: 16844115
    12. Wig-1-binding proteins, hnRNP A2/B1 and RNA Helicase A, both of which are involved in RNA processing, were identified. PMID: 18519039
    13. Data demonstrated a direct interaction between Dicer and Wig-1 and both may play a common role in dsRNA-related gene regulation. PMID: 19127773
    14. the p53 target Wig-1 is a previously undescribed AU-rich element-regulating protein that acts as a positive feedback regulator of p53, with implications both for the steady-state levels of p53 and for the p53 stress response PMID: 19805223

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  • 亚细胞定位：
    Nucleus. Nucleus, nucleolus.
  • 组织特异性：
    Highly expressed in adult brain, and moderately in adult kidney and testis. Not detected in fetal brain, heart, pancreas, adrenal gland, liver or small intestine.
  • 数据库链接：

    HGNC: 29983

    OMIM: 606452

    KEGG: hsa:64393

    STRING: 9606.ENSP00000311221

    UniGene: Hs.371609