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  4. Recombinant Human Zinc finger and BTB domain-containing protein 20 (ZBTB20)

Recombinant Human Zinc finger and BTB domain-containing protein 20 (ZBTB20)

  • 中文名称：
    人ZBTB20重组蛋白
  • 货号：
    CSB-YP867198HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人ZBTB20重组蛋白
  • 货号：
    CSB-EP867198HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人ZBTB20重组蛋白
  • 货号：
    CSB-EP867198HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人ZBTB20重组蛋白
  • 货号：
    CSB-BP867198HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人ZBTB20重组蛋白
  • 货号：
    CSB-MP867198HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ZBTB20
  • Uniprot No.：
  • 别名：
    Dendritic derived BTB/POZ zinc finger protein; Dendritic-derived BTB/POZ zinc finger protein; DKFZp566F123; DPZF; HOF; ODA 8S; OTTHUMP00000215066; OTTHUMP00000215067; OTTHUMP00000215069; OTTHUMP00000215071; ZBT20_HUMAN; Zbtb20; zinc finger 288; zinc finger and BTB domain containing 20; Zinc finger and BTB domain-containing protein 20; Zinc finger protein 288; ZNF288
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-741
  • 氨基酸序列
    MLERKKPKTA ENQKASEENE ITQPGGSSAK PGLPCLNFEA VLSPDPALIH STHSLTNSHA HTGSSDCDIS CKGMTERIHS INLHNFSNSV LETLNEQRNR GHFCDVTVRI HGSMLRAHRC VLAAGSPFFQ DKLLLGYSDI EIPSVVSVQS VQKLIDFMYS GVLRVSQSEA LQILTAASIL QIKTVIDECT RIVSQNVGDV FPGIQDSGQD TPRGTPESGT SGQSSDTESG YLQSHPQHSV DRIYSALYAC SMQNGSGERS FYSGAVVSHH ETALGLPRDH HMEDPSWITR IHERSQQMER YLSTTPETTH CRKQPRPVRI QTLVGNIHIK QEMEDDYDYY GQQRVQILER NESEECTEDT DQAEGTESEP KGESFDSGVS SSIGTEPDSV EQQFGPGAAR DSQAEPTQPE QAAEAPAEGG PQTNQLETGA SSPERSNEVE MDSTVITVSN SSDKSVLQQP SVNTSIGQPL PSTQLYLRQT ETLTSNLRMP LTLTSNTQVI GTAGNTYLPA LFTTQPAGSG PKPFLFSLPQ PLAGQQTQFV TVSQPGLSTF TAQLPAPQPL ASSAGHSTAS GQGEKKPYEC TLCNKTFTAK QNYVKHMFVH TGEKPHQCSI CWRSFSLKDY LIKHMVTHTG VRAYQCSICN KRFTQKSSLN VHMRLHRGEK SYECYICKKK FSHKTLLERH VALHSASNGT PPAGTPPGAR AGPPGVVACT EGTTYVCSVC PAKFDQIEQF NDHMRMHVSD G
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses. Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal.
  • 基因功能参考文献：
    1. ZBTB20 knockdown inhibited glioblastoma cell proliferation, migration, and invasion. PMID: 30099442
    2. High ZBTB20 expression is associated with hepatocellular carcinoma. PMID: 26893361
    3. We report a boy with intellectual disability carrying two de novo missense mutations in the last exon of ZBTB20 (Ser616Phe and Gly741Arg; both previously unreported). One of them, Ser616Phe, affects an amino acid located in one of the C2H2 zing-fingers involved in DNA-binding and close to other missense mutations already described. Reverse phenotyping showed that this patient presents with classic features of Primrose syn PMID: 27061120
    4. ZBTB20 rs9841504 polymorphism is a protective factor for gastric cancer rather than esophageal cancer. PMID: 27646774
    5. 3q13.31 microdeletion-based dosage imbalance of ZBTB20 linked to a range of neurodevelopmental, cognitive and psychiatric disorders, likely mediated by dysregulation of multiple ZBTB20 target genes. PMID: 25062845
    6. Major depressive disorder is associated with significant hypermethylation within the coding region of ZBTB20. PMID: 24694013
    7. important role for ZBTB20 in controlling NSCLC development PMID: 25311537
    8. Missense mutations in ZBTB20 underlie Primrose syndrome. PMID: 25017102
    9. This study disclosed Zbtb20-mediated transcriptional repressor mechanism may be involved in development of the human archicortex. PMID: 23283686
    10. Polymorphism in ZBTB20 gene is associated with gastric cancer. PMID: 23861218
    11. We identified new susceptibility loci for non-cardia gastric cancer at 3q13.31: rs9841504 in ZBTB20 PMID: 22037551
    12. ZBTB20 mRNA & protein expression were elevated significantly in HCC tissues compared with the paired non-tumor tissues & normal liver. HCC recurrence or metastasis increased & disease-free survival decreased with high ZBTB20 expression. PMID: 21702992
    13. Misexpression of Zbtb20 in transgenic mice converts the normal cytoarchitectonic organization of the subiculum, postsubiculum, and granular retrosplenial cortex to a CA1-like stratum pyramidale. PMID: 19955470

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  • 相关疾病：
    Primrose syndrome (PRIMS)
  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed in spleen, lymph node, thymus, peripheral blood leukocytes, and fetal liver.
  • 数据库链接：

    HGNC: 13503

    OMIM: 259050

    KEGG: hsa:26137

    STRING: 9606.ENSP00000419153

    UniGene: Hs.202577