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  4. Recombinant Human WW domain-binding protein 2 (WBP2)

Recombinant Human WW domain-binding protein 2 (WBP2)

  • 中文名称：
    人WBP2重组蛋白
  • 货号：
    CSB-YP842628HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人WBP2重组蛋白
  • 货号：
    CSB-EP842628HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人WBP2重组蛋白
  • 货号：
    CSB-EP842628HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人WBP2重组蛋白
  • 货号：
    CSB-BP842628HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人WBP2重组蛋白
  • 货号：
    CSB-MP842628HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    WBP2
  • Uniprot No.：
  • 别名：
    MGC18269; WBP 2; WBP-2; Wbp2; WBP2_HUMAN; WW domain binding protein 2; WW domain-binding protein 2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-261
  • 氨基酸序列
    MALNKNHSEG GGVIVNNTES ILMSYDHVEL TFNDMKNVPE AFKGTKKGTV YLTPYRVIFL SKGKDAMQSF MMPFYLMKDC EIKQPVFGAN YIKGTVKAEA GGGWEGSASY KLTFTAGGAI EFGQRMLQVA SQASRGEVPS GAYGYSYMPS GAYVYPPPVA NGMYPCPPGY PYPPPPPEFY PGPPMMDGAM GYVQPPPPPY PGPMEPPVSG PDVPSTPAAE AKAAEAAASA YYNPGNPHNV YMPTSQPPPP PYYPPEDKKT Q
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation. In presence of estrogen, binds to ESR1-responsive promoters. Required for YAP1 coactivation function on PGR activity. Synergizes with WBP2 in enhancing PGR activity. Modulates expression of post-synaptic scaffolding proteins via regulation of ESR1, ESR2 and PGR.
  • 基因功能参考文献：
    1. Data indicate WW-binding protein 2 (WBP2) as an important co-factor of YY1 associated protein 1 (YAP) that enhances YAP/TEAD-mediated gene transcription. PMID: 28332498
    2. WBP2/ITCH signaling functions to link the intricate Wnt and Hippo signaling networks in breast cancer. PMID: 27578003
    3. the miR-206/WBP2 axis can modulate tamoxifen sensitivity via regulating G1/S progression in estrogen receptor + breast cancer PMID: 28391353
    4. The s reported that the loss of Wbp2 expression leads to progressive high-frequency hearing loss in mouse, as well as in two deaf children, each carrying two different variants in the WBP2 gene. PMID: 26881968
    5. data indicate that WBP-2 enhances ER transactivation function at certain genes by facilitating the recruitment and/or the stabilization of a histone modifier enzyme that favors a relaxed chromatin structure, permissive of transcription PMID: 23233354
    6. The WW1 and WW2 domains of YAP2 recognize various PPXY motifs within WBP2 and WBP1 in a highly promiscuous and subtle manner. PMID: 21981024
    7. Data show that direct interaction of Wbp2 with TAZ depends on the WW domain of TAZ. PMID: 20972459
    8. WW domain binding protein-2, an E6-associated protein interacting protein, acts together with YAP as coactivators of estrogen and progesterone receptors. PMID: 16772533

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  • 相关疾病：
    Deafness, autosomal recessive, 107 (DFNB107)
  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 12738

    OMIM: 606962

    KEGG: hsa:23558

    STRING: 9606.ENSP00000254806

    UniGene: Hs.514489