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  4. Recombinant Human WD repeat-containing protein 73 (WDR73)

Recombinant Human WD repeat-containing protein 73 (WDR73)

  • 货号：
    CSB-YP744047HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP744047HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP744047HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP744047HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP744047HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    WDR73
  • Uniprot No.：
  • 别名：
    WDR73; HSPC264WD repeat-containing protein 73
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-378
  • 氨基酸序列
    MDPGDDWLVE SLRLYQDFYA FDLSGATRVL EWIDDKGVFV AGYESLKKNE ILHLKLPLRL SVKENKGLFP ERDFKVRHGG FSDRSIFDLK HVPHTRLLVT SGLPGCYLQV WQVAEDSDVI KAVSTIAVHE KEESLWPRVA VFSTLAPGVL HGARLRSLQV VDLESRKTTY TSDVSDSEEL SSLQVLDADT FAFCCASGRL GLVDTRQKWA PLENRSPGPG SGGERWCAEV GSWGQGPGPS IASLGSDGRL CLLDPRDLCH PVSSVQCPVS VPSPDPELLR VTWAPGLKNC LAISGFDGTV QVYDATSWDG TRSQDGTRSQ VEPLFTHRGH IFLDGNGMDP APLVTTHTWH PCRPRTLLSA TNDASLHVWD WVDLCAPR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play a role in the regulation of microtubule organization and dynamics.
  • 基因功能参考文献：
    1. We expanded the clinical phenotype of GMS with WDR73 gene defect to include retinal dysfunction with missense mutation and developmental dysplasia of the hip. PMID: 29929488
    2. WDR73 as a candidate gene of severe intellectual disability and cerebellar hypoplasia. PMID: 27983999
    3. We document postnatal onset of CA, a retinopathy, basal ganglia degeneration, and short stature as novel features of WDR73-related disease, and define WDR73-related disease as a new entity of infantile neurodegeneration. PMID: 26123727
    4. Nonsense mutation in the WDR73 gene is associated with Galloway-Mowat syndrome PMID: 25873735
    5. WDR73 interacts with mitotic microtubules to regulate cell cycle progression, proliferation and survival in brain PMID: 26070982
    6. WDR73 plays a crucial role in the maintenance of cell architecture and cell survival. PMID: 25466283

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  • 相关疾病：
    Galloway-Mowat syndrome 1 (GAMOS1)
  • 亚细胞定位：
    Cytoplasm, cytosol. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Cleavage furrow.
  • 蛋白家族：
    WD repeat WDR73 family
  • 组织特异性：
    Expressed in kidney and brain. In the kidney, expressed in glomeruli, most probably in podocytes, and in tubules (at protein level). In the brain, expressed in the cerebellum, with high levels in Purkinje cells and their projecting axons, in the deep cere
  • 数据库链接：

    HGNC: 25928

    OMIM: 251300

    KEGG: hsa:84942

    STRING: 9606.ENSP00000387982

    UniGene: Hs.745027