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  4. Recombinant Human VIP peptides (VIP)

Recombinant Human VIP peptides (VIP)

  • 中文名称：
    人VIP重组蛋白
  • 货号：
    CSB-YP025858HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人VIP重组蛋白
  • 货号：
    CSB-EP025858HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人VIP重组蛋白
  • 货号：
    CSB-EP025858HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人VIP重组蛋白
  • 货号：
    CSB-BP025858HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人VIP重组蛋白
  • 货号：
    CSB-MP025858HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    VIP
  • Uniprot No.：
  • 别名：
    Peptide histidine methioninamide 27; Peptide histidine valine 42; PHM27; PHV42; Prepro VIP; Vasoactive intestinal peptide; Vasoactive intestinal polypeptide; VIP; VIP peptides; VIP peptides precursor; VIP_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Cytoplasmic domain
  • 表达区域：
    81-122
  • 氨基酸序列
    HADGVFTSDF SKLLGQLSAK KYLESLMGKR VSSNISEDPV PV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.; PHM and PHV also cause vasodilation. PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin.
  • 基因功能参考文献：
    1. VIP SNPs are associated with VIP serum level and response to rheumatoid arthritis treatment. PMID: 29391448
    2. this review provides an overview of VIP effects on rheumatoid arthritis pathology PMID: 30155495
    3. Results have suggested that pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP), but predominantly VIP, induce neuroblastoma differentiation into benign form by regulating hypoxia-inducible factors, vascular endothelial growth factor and vascular endothelial growth factor receptor expression and distribution. PMID: 29699729
    4. Results found that VIP enhanced trophoblast cell migration and invasion through the activation of high affinity VPAC receptors and PKA-CRE signaling pathways suggesting that VIP-mediated autocrine pathways regulate trophoblast cell function and contribute to immune homeostasis maintenance at placentation. PMID: 27212399
    5. this study shows that that VIP exerts anti-inflammatory effects by inhibiting the MAPK-p47phox phosphorylation-NOX2 activation axis, and that VIP dampens carrageenan-induced inflammation in rats PMID: 27271317
    6. Both mast cells and VIP appear to be important factors in the regulation of this bacterial translocation through the colonic mucosa of irritable bowel syndrome patients. PMID: 28711627
    7. we found that VIP inhibits NFAT nuclear translocation in primary human pulmonary artery smooth muscle cells (PASMC). Early activation of NFATc3 in IPF patients may contribute to disease progression and the increase in VIP expression could be a protective compensatory mechanism PMID: 28125639
    8. VIP and CRF reduce ADAMTS expression and function in osteoarthritis synovial fibroblasts. PMID: 26818776
    9. optogenetically activating single VIPs in live mice while recording the activity of nearby neurons, we find that VIPs break open a hole in blanket inhibition. PMID: 27013676
    10. a differential effect of VIP on the expression of TNFalpha and IL-6 receptors, since VIP was only able to decreased expression in LPS-stimulated monocytes but not in 4/74-infected monocytes. PMID: 26206287
    11. VIP promotes Th17 polarization of memory Th cells in early arthritis. PMID: 25957307
    12. The circadian rhythm amplitude of motor activity in both Alzheimer disease subjects and age-matched controls is correlated with the number of vasoactive intestinal peptide-expressing suprachiasmatic nucleus neurons. PMID: 25921596
    13. Skin VIP expression, a marker of sudomotor innervation, was significantly lower in patients with familial transthyretin amyloid neuropathy compared to controls. PMID: 25973863
    14. Alterations in VIP expression may play a role in irritable bowel syndrome. PMID: 25574088
    15. Interictal CGRP and, to a lesser degree, VIP levels measured in peripheral blood are of great help in predicting response of chronic migraine patients to Onabotulinumtoxin type A PMID: 24673487
    16. The antimicrobial peptide, VIP is a neuropeptide with activity against a range of microorganisms from skin, oral, respiratory and gastrointestinal tract sites. PMID: 18603306
    17. VIP is significantly increased in the patients with chronic obstructive pulmonary disease and pulmonary hypertension. PMID: 24228853
    18. Serum levels of vasoactive intestinal peptide as a prognostic marker in early arthritis. PMID: 24409325
    19. Data suggest that two closely related neuroprotective peptides, vasoactive intestinal peptide (VIP) and pituitary adenylyl cyclase-activating peptide (PACAP), are up-regulated in neurons/immune cells after injury and/or inflammation. [REVIEW] PMID: 23517078
    20. Our study suggested that baicalein exerts a positive effect on the VIP expression in HCMV-infected EVT at maternal-fetal interface. PMID: 23771668
    21. VIP can inhibit the cytotoxicity of natural killer cells to MKN45 cells and can inhibit the expressions of NKG2D, DAP10, and NF-kappaB in natural killer cells. PMID: 24228003
    22. The results of this study indicate a connection between elevated concentration of NPY and VIP and decreased DPP IV/CD26 activity and concentration, suggesting a potential role of these molecules in the immunomodulation of rheumatoid arthritis. PMID: 23864142
    23. VIP induced expression of CCL5, one of the main chemokines involved in T cell recruitment. PMID: 24492467
    24. VIP expression and its receptors' polymorphism may be important in determining susceptibility to progression from mild to severe forms of Chagas disease. PMID: 23800435
    25. Expression and distribution of phosphodiesterase (PDE) type 1, known to hydrolyze both cyclic AMP and -GMP, are evaluated with VIP in the vagina where their signaling pathways are involved in control of vaginal blood flow. PMID: 23490535
    26. The present study found that reduced VIP innervation in the vaginal epithelium of the perimenopausal women was correlated with the severity of pelvic organ prolapse with or without stress incontinence. PMID: 23915857
    27. VIP and pituitary adenylate cyclase-activating polypeptide (PACAP) may influence the course of multiple sclerosis. PMID: 24041830
    28. Either PACAP or VIP were able to recover the retinal pigment epithelial barrier hyperpermeability and the reduced transepithelial electrical resistance. PMID: 23220033
    29. VIP in synovial fluid and articular cartilage is negatively associated with progressive joint damage in osteoarthritis and is a potential indictor of disease severity. PMID: 22959974
    30. Confocal images and FACS demonstrated a strong association and co-localization between VIP peptide and CRTH2 molecules PMID: 23168411
    31. An imbalance between vasoactive intestinal peptide and substance P production results in the reestablishment and maintenance of the inflammatory process, leading to denervation and, consequently, promoting the development of megaesophagus. PMID: 22995328
    32. A set of cryosections revealed extensive colocalization of calretinin with vasoactive intestinal peptide in both surviving submucosal perikarya and mucosal nerve fibres in human chagasic submucosa and mucosa. PMID: 22555304
    33. The present work was undertaken to investigate the antiproliferative potential of vasoactive intestinal peptide (VIP) exposure on non-tumoral (HK2) and tumoral (A498, cRCC) human proximal tubular epithelial cell lines. PMID: 22728770
    34. Vasoactive intestinal polypeptipe and GRIN3A SNPs may be associated with cerebral palsy at age 2 in children born preterm. PMID: 22914463
    35. results strongly suggest that VIP synergistically enhances TNF-alpha-stimulated IL-6 and IL-8 synthesis via activating the NF-kappa-B pathway in HK-2 cells PMID: 22207455
    36. We hypothesized that VIP plays a role in the activation of parasympathetic cranial outflow during migraine attacks PMID: 22108610
    37. Physical exercise stimulates production of natural anti-VIP antibodies and likely results in suppression of VIP. PMID: 22140573
    38. One year after sigmoid colon vaginoplasty, VIP expression was significantly lower in the neovagina than in the intact sigmoid colon, but increased 3 years postoperatively. PMID: 21426768
    39. Blood levels of vasoactive intestinal polypeptide tended to be high in patients with ankylosing spondylitis as compared with those of healthy subjects and correlated with platelet counts significantly, for the first time at the literature. PMID: 20340024
    40. Results demonstrate that meibomian gland epithelial transformed cells transcribe and translate VIP and mACh receptors. PMID: 21969302
    41. The VIP level of the nasal septum in the perennial allergic rhinitis patients was higher than that in the normal controls. PMID: 19685709
    42. Substance P and VIP neurofibers are present in the fibroid pseudocapsule of uterine fibroids, similar to the values in the normal myometrium of a non-pregnant uterus. PMID: 21167238
    43. SP, CGRP and VIP may play important roles in the pathophysiological mechanism of vasomotor rhinitis. PMID: 17087112
    44. SP levels are higher in repeat cesarean section, while the VIP levels are reduced in the lower uterine segment. PMID: 20692311
    45. VIP increases its own intracellular and extracellular levels, and could be involved in the regulation of VPAC(1)-receptor traffic from the plasma membrane to the nucleus. PMID: 20691743
    46. Data show that 1/3 of pediatric slow-transit constipation patients have low substance P or vasoactive intestinal peptide nerve fiber density in proximal colon. PMID: 20529207
    47. Data describe neurons and nerve fibers of intestinal plexuses containing vasoactive intestinal peptide, pituitary adenylate cyclase-activating polypeptide and neuropeptide Y in pathologically changed parts of the large intestine in intestinal cancer. PMID: 20675276
    48. Data show that TG2-L and TG2-S enhanced neuroblastoma cell differentiation due to N-Myc small interfering RNA, and suppression of vasoactive intestinal peptide (VIP) expression alone induced neuroblastoma cell differentiation. PMID: 20007697
    49. Besides their presence and functions in the gut and the brain VIP and PACAP have distinct physiological roles in the genital tract. PMID: 11713978
    50. Circulating VIP in fulminant hepatic failure seems to reflect hemodynamic changes in the systemic rather than in the cerebral circulation. PMID: 11884208

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Glucagon family
  • 数据库链接：

    HGNC: 12693

    OMIM: 192320

    KEGG: hsa:7432

    STRING: 9606.ENSP00000356213

    UniGene: Hs.53973