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  4. Recombinant Human Urocortin (UCN)

Recombinant Human Urocortin (UCN)

  • 货号：
    CSB-YP025551HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP025551HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP025551HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP025551HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP025551HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    UCN
  • Uniprot No.：
  • 别名：
    prepro-urocortin; Ucn; UCN1_HUMAN; UI; UROC; Urocortin; Urocortin precursor; urocortin; preproprotein; Urotensin I
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Cytoplasmic domain
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta. Plays a role in the establishment of normal hearing thresholds. Reduces food intake and regulates ghrelin levels in gastric body and plasma.
  • 基因功能参考文献：
    1. REVIEW: Cardioprotective Utility of Urocortin in Myocardial Ischemia- Reperfusion Injury: Where do We Stand? PMID: 28228090
    2. In women with chronic pelvic pain, infertility, or both symptoms, the probability of endometriosis (positive predictive value) increased consistently with the increase of plasma Ucn1 levels. PMID: 28925754
    3. Study found reduced miR-326 levels concomitant with elevated Ucn1 levels in Edinger-Westphal nucleus (EWcp) of depressed suicide completers and in the EWcp of depressed rats. In fully recovered rats, both serum and EWcp miR-326 levels rebounded to nonstressed levels. While downregulation of miR-326 levels in primary midbrain neurons enhanced Ucn1 expression levels, miR-326 overexpression selectively reduced its levels. PMID: 27045550
    4. In deep infiltrating endometriotic lesions, CRH, Ucn and CRH-R2 mRNA levels were significantly higher than in ovarian endometrioma. PMID: 27567427
    5. UCN I is secreted from human glioblastoma cells by exocytosis through constitutive secretory granules. PMID: 25239507
    6. Findings identify Ucn as a potential mediator that inhibits TGFbeta1 oncogenic signaling in breast neoplasm. PMID: 26138318
    7. In women with adnexal endometrioma versus teratoma, the medians were 105.31 pg/mL versus 120.84 pg/mL for urocortin, 7.16 pg/mL versus 9.13 pg/mL for leptin and 584.33 pg/mL versus 657.82 pg/mL for ghrelin (p > 0.05), respectively. PMID: 25951715
    8. Ucn1 prevents the development of atherosclerosis by suppressing EC inflammatory response and proliferation, macrophage foam cell formation, and VSMC migration and proliferation PMID: 25462164
    9. down-regulated expression in the placenta and maternal serum during intrahepatic cholestasis of pregnancy may impair the blood flow regulation of the utero-placental-fetal unit and contribute to fetal distress PMID: 25172671
    10. Production of CRF and UCN1 in human dendritic cells is strongly augmented by commensal intestinal bacteria. PMID: 25339828
    11. Cardioplegic arrest failed to induce cardiac myocyte overexpression of urocortin in diabetic hearts. PMID: 24954177
    12. Urocortin expression inversely correlates with higher tumor grade and advanced tumor stage in gastric adenocarcinomas. PMID: 23531852
    13. all neonates expressed UCN1 in the Edinger-Westphal nucleus independent of the degree of neuropathological injury. PMID: 24012814
    14. Ucn is both an essential chondrocyte survival signal peptide and a chondroprotective agent in the presence of pro-apoptotic stimuli. PMID: 23846219
    15. A detailed conformational model for the CRF1R-Ucn1 complex based on the many ligand-receptor interactions determined was here and eventually revealed unique features of peptide ligand binding to class B GPCRs. PMID: 24290358
    16. during the midluteal phase of the cycle, metformin may decrease the production of corticotropin-releasing hormone and UCN in the endometrium. PMID: 23987517
    17. Data suggest that low urocortin-1 concentration in midtrimester amniotic fluid is an early indicative marker of preterm birth. PMID: 23803006
    18. Serum urocortin could not predict women who delivered preterm among women with signs of preterm labor. PMID: 22639902
    19. Dihydrotestosterone decrease the expression of urocortin in human umbilical vein endothelial cells. PMID: 23801677
    20. Confirm the anti-inflammatory function of VIP, through the modulation of the expression of CRF system that impacts in a reduction of mediators with inflammatory/destructive functions. PMID: 21360527
    21. not found to be efficient in distinguishing endometrioma from other benign ovarian cysts or to be superior to CA125 in the diagnosis of endometrioma PMID: 20480172
    22. nuclear translocation of Ucn along with the loss of CRFR2 in epithelial cells and microvasculature of tumoral specimens may be involved in the pathobiology of renal cell carcinoma PMID: 19437022
    23. Women with endometriosis show an impaired endometrial expression of CRH and Ucn mRNA. PMID: 21289256
    24. Higher plasma levels of urocortin-1, but not urocortin-II, are associated with worse left ventricular diastolic performance in patients with chronic systolic heart failure. PMID: 20670842
    25. This article provides a review of the role of urocortins in normal cardiovascular physiology and in the pathophysiology of heart failure. PMID: 20363214
    26. UCN is produced during the development of mesenchymal progenitor cells to osteoblasts and differentially regulated during culture as well as by differentiation factors. PMID: 19949969
    27. Urocortin peptide and mRNA was significantly increased in women with preeclampsia. PMID: 15924674
    28. Results demonstrate that plasma concentrations of UCN are significantly increased in patients with heart failure (HF). UCN may participate in the neurohumoral response of HF. PMID: 19961889
    29. Results suggest that urocortin concentrations in the amniotic fluid of genetic amniocentesis are not predictive of preterm labor and birth. PMID: 19893766
    30. The low amniotic fluid concentrations of urocortin at mid-trimester may be a signal of predisposition to preterm delivery. PMID: 19619932
    31. a highly significant, but negative, correlation has been found between Ucn levels and gastric inflammation, suggesting that Ucn may exert an antiinflammatory effect in gastric mucosa PMID: 12519893
    32. SCP and UCN are potent activators of the p42/44 MAPK pathway, with SRP able to induce phosphorylation of p42/44 MAPK as well, albeit not as pronounced PMID: 14519439
    33. human cord blood-derived cultured mast cells (hCBMC) at 10 wk, but not at 2 wk, are immunocytochemically positive for CRH and UCN PMID: 14576187
    34. Adipose tissue expressed urocortin and stresscopin, the predominant ligands of peripheral CRH-R2. PMID: 14764822
    35. mRNA expression of urocortin was low during the last weeks of pregnancy in the placenta, myometrium and choriodecidua PMID: 15072543
    36. urocortin may regulate uterine artery tone at mid gestation. PMID: 15784504
    37. Urocortin potently suppressed the generation of angiotensin II-induced reactive oxygen species (ROS) in HUVECs. Tumor necrosis factor-alpha, interferon-gamma & pitavastatin increased the urocortin mRNA levels and its release from HUVECs. PMID: 16340217
    38. CRH peptides can differentially influence hair follicle melanocyte behavior not only via CRH-R1 signaling but also by complex cross-talk between CRH-R1 and CRH-R2. PMID: 16675846
    39. expression of UCN in extravillous trophoblast cells and the activation of the UCN gene promoter by the diacylglycerol/PKC pathway PMID: 16698078
    40. The evidence that (i) UCN is highly expressed in the secretory phase of the endometrial cycle; (ii) cAMP & E(2) + MPA modulate secretion of UCN & (iii) UCN induces HESCs decidualization together suggest a possible role for UCN in endometrial physiology. PMID: 16920724
    41. NPY, via NPY Y5 and to a lesser extent via the Y1 receptors, exerts a stimulatory action on Ucn1 cells in the nonpreganglionic Edinger-Westphal nucleus. PMID: 17154253
    42. In allergic nasal mucosa, increased expression levels of urocortin and its receptors may contribute to increased mucosal swelling and vascular permeability, playing an important role in the pathogenesis of allergic rhinitis. PMID: 17597629
    43. CRF-BP has distinct and separable binding surfaces for CRF and Ucn 1 PMID: 18234674
    44. The Ucn1-mRNA level in non-preganglionic Edinger-Westphal nucleus neurons is about 9.12 times higher in male but unchanged in female suicide victims. PMID: 18329817
    45. UCN inhibited the proliferation and promoted the apoptosis of endothelial cells and down-regulated VEGF expression in vivo via CRFR2. PMID: 18443956
    46. Ucn showed a significant role in the regulation of local inflammation, proliferation, and relaxation of smooth muscle tone in different organs through activation of corticotropin releasing factor receptor 2 (CRFR2). PMID: 18670748
    47. reverses LPS-induced TNF-alpha release from trophoblast PMID: 19703147
    48. Plasma urocortin 1 is elevated in heart failure (in proportion to the degree of cardiac dysfunction) in concert with the generalized neurohormonal activation seen in this condition. PMID: 19808377

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Sauvagine/corticotropin-releasing factor/urotensin I family
  • 组织特异性：
    Keratinocytes in epidermis and the outer and inner root sheaths of hair follicles, epithelium of sebaceous and sweat glands, erector pili muscle, cutaneous blood vessel walls, cutaneous nerves and dermal mononuclear cells. Detected in plasma cells in the
  • 数据库链接：

    HGNC: 12516

    OMIM: 600945

    KEGG: hsa:7349

    STRING: 9606.ENSP00000296099

    UniGene: Hs.534363