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  4. Recombinant Human UPF0723 protein C11orf83 (C11orf83)

Recombinant Human UPF0723 protein C11orf83 (C11orf83)

  • 中文名称：
    人UQCC3重组蛋白
  • 货号：
    CSB-YP754404HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人UQCC3重组蛋白
  • 货号：
    CSB-EP754404HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人UQCC3重组蛋白
  • 货号：
    CSB-EP754404HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人UQCC3重组蛋白
  • 货号：
    CSB-BP754404HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人UQCC3重组蛋白
  • 货号：
    CSB-MP754404HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    UQCC3
  • Uniprot No.：
  • 别名：
    UQCC3; C11orf83; UNQ655/PRO1286; Ubiquinol-cytochrome-c reductase complex assembly factor 3; Assembly factor CBP4 homolog
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    24-93
  • 氨基酸序列
    LLVIVTP GERRKQEMLK EMPLQDPRSR EEAARTQQLL LATLQEAATT QENVAWRKNW MVGGEGGAGG RSP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin-binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology.
  • 基因功能参考文献：
    1. Mitochondrial C11orf83 is a potent antiviral protein independent of interferon production; and knockdown of either OAS3 or RNase L impaired the antiviral capability of C11orf83. PMID: 28418037
    2. UQCC3 functions in complex III assembly and that the c.59T>A mutation has a causal role in complex III deficiency. PMID: 25008109
    3. C11orf83 depletion in HeLa cells caused abnormal crista morphology, higher sensitivity to apoptosis, a decreased ATP level due to impaired respiration and subtle, but significant, changes in cardiolipin composition. PMID: 25605331
    4. AY358935 is a predicted secretary protein with a small molecular weight that might have important functions in cellular proliferation and anti-viral innate immune regulation. PMID: 20159687
  • 相关疾病：
    Mitochondrial complex III deficiency, nuclear 9 (MC3DN9)
  • 亚细胞定位：
    Mitochondrion inner membrane; Single-pass membrane protein.
  • 蛋白家族：
    UQCC3 family
  • 数据库链接：

    HGNC: 34399

    OMIM: 616097

    KEGG: hsa:790955

    STRING: 9606.ENSP00000367189

    UniGene: Hs.569009