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  4. Recombinant Human Transient receptor potential cation channel subfamily V member 6 (TRPV6), partial

Recombinant Human Transient receptor potential cation channel subfamily V member 6 (TRPV6), partial

  • 中文名称：
    人TRPV6重组蛋白
  • 货号：
    CSB-YP861992HU1
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人TRPV6重组蛋白
  • 货号：
    CSB-EP861992HU1
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人TRPV6重组蛋白
  • 货号：
    CSB-EP861992HU1-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人TRPV6重组蛋白
  • 货号：
    CSB-BP861992HU1
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人TRPV6重组蛋白
  • 货号：
    CSB-MP861992HU1
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    TRPV6; ECAC2; Transient receptor potential cation channel subfamily V member 6; TrpV6; CaT-like; CaT-L; Calcium transport protein 1; CaT1; Epithelial calcium channel 2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine. Important for normal Ca(2+) ion homeostasis in the body, including bone and skin. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.
  • 基因功能参考文献：
    1. Transient neonatal hyperparathyroidism is an autosomal-recessive disease caused by TRPV6 mutations that affect maternal-fetal calcium transport. PMID: 29861107
    2. this review describes the role of TRPV6 in male fertility and cancer PMID: 28501141
    3. High TRPV6 expression is associated with development and progression of pancreatic cancer. PMID: 29344675
    4. cryo-electron microscopy structures of human TRPV6 in the open and closed states PMID: 29258289
    5. TRPV5 and TRPV6 lack a positively charged residue in the TM4-TM5 loop that was shown to interact with PI(4,5)P2 in TRPV1, which shows high affinity for this lipid PMID: 27291418
    6. TRPV6 down-regulation is associated with decreased Ca(2+) response pattern and reduced NFAT activity. PMID: 27450545
    7. TRPV6 expression is significantly decreased in chondrocytes from patients with osteoarthritis of the knees. TRPV6 could regulate certain chondrocyte functions, including ECM secretion, cell proliferation, and apoptosis. PMID: 28063212
    8. The findings indicate that p38alpha and GADD45alpha are involved in an enhanced vitamin D signaling on TRPV6 expression. PMID: 28578001
    9. TRPV6 is down-regulated in esophageal squamous cell carcinoma and plays a role in predicting survival of male and female patients. PMID: 26818094
    10. These results suggest that CAT-1 is a novel CAM that directly regulates endothelial integrity and mediates the protective actions of L-Arg to endothelium via a NO-independent mechanism. PMID: 26283571
    11. TRPV6 calcium ion channel plays a critical role in flow-induced Ca(2+) influx and microvilli formation. PMID: 26563429
    12. our results demonstrate that hCAT-1 is a key component of efficient T-cell activation PMID: 26449889
    13. TRPV6 and PLC-delta1 are critical actor of Ca(2+) homeostasis in CF human bronchial epithelial cells. PMID: 25477137
    14. focus on TRPV6 gene polymorphisms, the start of TRPV6 translation at a non-AUG codon and the functions of TRPV6 in intestinal Ca(2+) uptake, sperm maturation, and male fertility. PMID: 25372600
    15. TRPV6 channel acquires its oncogenic potential in prostate cancer due to the remodeling mechanism via the Orai1-mediated calcium/Annexin I/S100A11 pathway. PMID: 25172921
    16. High TRPV6 expression is aassociated with adenoma of parathyroid glands. PMID: 25164318
    17. A non-AUG start codon in used in both human and mouse, extending the N-terminus of the protein by 40 amino acids. The increased translation of the smaller TRPV6 cDNA version may overestimate the in vivo situation where translation efficiency may represent an additional mechanism to tightly control the TRPV6-mediated Ca(2+) entry to prevent deleterious Ca(2+) overload PMID: 23612980
    18. Decreased expression of TRPV6 is associated with non-small cell lung cancer. PMID: 24761864
    19. These results suggest that TRPV5 and TRPV6 are crucial gates controlling cadmium and zinc levels in the human body. PMID: 23968883
    20. these data showed that TRPV5/TRPV6 in human lymphocytes are functionally active, and their activity is associated with proliferative status of blood cells. PMID: 24592736
    21. Overexpression of miR-122 and concomitant suppression of CAT1 in the primary tumor appears to play important roles in the development of colorectal liver metastasis. PMID: 23373973
    22. The interaction of TRPV6 and Numb1 influences TRPV6-mediated Ca2+ influx. PMID: 23140583
    23. Increased TRPV6 expression is a feature of estrogen receptor (ER)-negative breast tumors. PMID: 22807578
    24. Ca(2+), CaM, and the depletion of PI(4,5)P(2) all contribute to inactivation of TRPV6 PMID: 23300090
    25. Intestinal TRPV6 function in Ca and bone metabolism in wild-type (WT) and vitamin D receptor knockout (VDRKO) mice, was tested. PMID: 22589201
    26. a functional interaction of TRPC1 with TRPV6 that negatively regulates Ca(2+) influx in HEK293 cells. PMID: 22932896
    27. The TRPV6 is a close homolog of TRPV5, yet their calmodulin binding sites display diversity in binding modes, binding stoichiometries and binding affinities which may fine-tune the response of the channels to varying Ca(2+)-concentrations. PMID: 22354706
    28. Knocking down endogenous OCRL by antisense approach increased TRPV6-mediated Ca(2+) transport and TRPV6 forward trafficking. PMID: 22378746
    29. Data show that the transient receptor potential ion channel TRPV6 is expressed only at low levels in osteoblasts and plays little functional role in osteoblastic calcium uptake. PMID: 22163264
    30. Data suggest that TRPV6 and other proteins involved in transcellular Ca(2+) transport are dynamically expressed in bone cells, while TRPV6 appears not crucial for bone metabolism and matrix mineralization. PMID: 21732366
    31. Our data establish PtdIns(4,5)P(2) as a direct activator of TRPV6 and demonstrate that intracellular ATP regulates the channel indirectly as a substrate for type III PI4Ks PMID: 21810903
    32. Immunohistochemical analysis of the distribution of TRPV6 and PMCA1 in the uterus revealed that both proteins are abundantly expressed in the cytoplasm of endometrial and glandular epithelial cells during menstrual phases. PMID: 21400627
    33. Data show that TRPV5 and TRPV6 expression is decreased in PE. PMID: 20178461
    34. TRPV6 is not only involved in calcium transport but also in the transport of other divalent cations, including heavy metal ions, which may have toxicological implications. PMID: 21146870
    35. endogenous TRPV6 channels are activated downstream of a G protein-coupled receptor and present the first physiological characterization of these channels in situ. PMID: 21349844
    36. allele with 3 derived nonsynonymous SNPs (157C, 378M, 681M) of gene encoding calcium permeable TRPV6 humans having derived-TRPV6 in non-African areas may absorb higher Ca(2)+ from intestine than ancestral-TRPV6 in Africa PMID: 20948163
    37. Quercetin aglycon supplementation gives rise to stimulate TRPV6 gene expression in the upper small intestine, which improves calcium absorption from epithelia. PMID: 21228504
    38. Studies indicate that TRPV6 was present in PCa tissue specimens and in lymph node metastasis, but not in BPH or in normal prostate. PMID: 20730379
    39. TRPV6-targeted siRNA can inhibit the transcription of TRPV6, and inhibit proliferation, arrest the cell cycle and induce apoptosis of LNCaP cells. PMID: 20684323
    40. Retinal pigment epithelium expresses the epithelial calcium channels TRPV5 and TRPV6, the most calcium-selective channels of the TRP superfamily. PMID: 20405023
    41. Data conclude that PIKfyve participates in the regulation of TRPV6. PMID: 20041238
    42. Although expression of trpv6 transcripts correlates with aggressive potential of prostate cancer, the TRPV6 genotype does not correlate with the onset of prostate cancer. PMID: 19857260
    43. 1,25-Dihydroxyvitamin D3 increases mRNA expression of the CaT1 calcium channel in the Caco-2 intestinal cell line. PMID: 11545681
    44. to characterize ECaC2 in more detail and to compare ites properties with those of Ecac1 to obtain a better understanding of transcellular Ca2+ transport in epithelia PMID: 11744752
    45. regulatory component that controls activation of both CaT1 and CRAC (Ca(2+) release-activated Ca(2+) channel) channels. PMID: 12011062
    46. role of TRPV6 as calcium sensor in rat and human cells PMID: 12138163
    47. CaT1 is the channel protein that contributes to T-lymphocyte stores-operated Ca(2+) channels either alone or as a subunit in a heterogeneous channel complex. PMID: 12361955
    48. Our results indicate that the pattern of CaT1 and CaT2 expression correlates with the Ca2+ uptake potential along the differentiation of cultured human trophoblasts isolated from term placenta. PMID: 12390878
    49. the role of CaT1 in generating endogenous store-operated Ca(2+) current (I(SOC)) in the lymph node carcinoma of the prostate (LNCaP) human prostate cancer epithelial cell line PMID: 12584203
    50. The effects of intracellular Mg(2+) on TRPV6 are partially reminiscent of the gating mechanism of inwardly rectifying K(+) channels and may represent a novel regulatory mechanism for TRPV6 function in vivo. PMID: 12601087

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Transient receptor (TC 1.A.4) family, TrpV subfamily, TRPV6 sub-subfamily
  • 组织特异性：
    Expressed at high levels in the gastrointestinal tract, including esophagus, stomach, duodenum, jejunum, ileum and colon, and in pancreas, placenta, prostate and salivary gland. Expressed at moderate levels in liver, kidney and testis. Expressed in tropho
  • 数据库链接：

    HGNC: 14006

    OMIM: 606680

    KEGG: hsa:55503

    STRING: 9606.ENSP00000352358

    UniGene: Hs.302740