Recombinant Human Transforming growth factor-beta-induced protein ig-h3 (TGFBI)

1. These results suggest that suppression of osteoblast differentiation by BIGH3 is one of the mechanisms that enhance osteolytic lesions in RCC bone metastasis, and raise the possibilty that treatments that increase bone formation may improve therapy outcomes. PMID: 29190493
2. High TGFBI expression was significantly associated with poor prognosis and cancer progression. Downregulation of TGFBI in the cocultured gastric fibroblasts inhibited the invasion and migration abilities of the GC cells. PMID: 30260476
3. Expression array analysis identified TGFBI as a key gene for the acquisition of malignant phenotype of pancreatic ductal adenocarcinoma (PDAC), and the expression of TGFBI was associated with poor prognosis in patients with PDAC. PMID: 30156359
4. the genetic screening of TGFBI mutations must be incorporated into the pre-operative screening procedures to prevent exacerbation and recurrence, which eventually could lead to the need for a corneal transplant. PMID: 29192679
5. Structural and functional implications of TGFBIp mutations in corneal dystrophies have been reported. PMID: 28988748
6. Induction of TGFBI promotes prostate cancer growth and metastasis and can be caused by dysregulation or therapeutic inhibition of androgen receptor signaling. PMID: 28811384
7. betaig-h3 in DPCs may be involved in reparative dentin formation and that its expression is likely to negatively regulate this process. PMID: 28292713
8. This is the first molecular analysis of TGFBI and CHST6 in Turkish patients with different types of corneal dystrophies. PMID: 27829782
9. The more structurally organized A546T and V624M mutations in FAS1-4 domain of TGFBI had reduced deamidation rates, suggesting that a folded and stable FAS1-4 domain precludes Asn622 deamidation. PMID: 29140698
10. A novel heterozygous TGFBI mutation was identified in the proband, c.1673T>G in exon 12 that leads to (Leu558Arg) change at the protein level. PMID: 27028151
11. TGFBI and periostin act similarly in the heart in affecting fibrosis and disease responsiveness. PMID: 28750100
12. The p.(Val113Ile) mutation results in an alteration of the atypical LCD phenotype associated with the p.(Leu558Pro) mutation. This represents only the second report of the alteration of the phenotype of a TGFBI dystrophy by a second, non-homozygous pathogenic mutation, and thus provides insight into the phenotype-genotype correlation of the TGFBI dystrophies. PMID: 27402970
13. Our findings demonstrate that granular corneal dystrophy type 1 may present with a vortex pattern of anterior stromal deposits. Although this pattern of dystrophic deposits is not recognized by clinicians as a typical phenotype of GCD1, it is consistent with the production of the majority of the TGFBI protein by the corneal epithelium. PMID: 28060069
14. The right cornea showed a higher number of lattice lines than the left cornea. Molecular analysis involving bidirectional complete sequencing demonstrated a novel T621P mutation in exon 14 of TGFBI. PMID: 27163623
15. LASIK surgery of granular corneal dystrophy type 2 patients leads to accumulation and differential proteolytic processing TGFBI protein. PMID: 26864644
16. High TGFBI expression in Esophageal squamous cell carcinoma is associated with hematogenous recurrence. PMID: 25448803
17. Vicenin-2 and scolymoside could be a potential therapeutic agent for treatment of various severe vascular inflammatory diseases via inhibition of the TGFBIp signaling pathway. PMID: 26084452
18. We observed that knockdown of Cul4A was associated with increased sensitivity to gemcitabine through upregulation of TGFBI in lung cancer cells. PMID: 26503734
19. Data suggest that periostin and TGFBI (transforming growth factor-beta induced protein) can be considered paralogs in some ways: structural homology, phylogeny, and functions in extracellular matrix formation/cell adhesion/cellular immunity. [REVIEW] PMID: 26288337
20. No mutations were detected in the TGFBI gene in Korean patients with macular corneal dystrophy. PMID: 26604660
21. TGFBIp functions as a pro-lymphangiogenic factor.TGFBI is a lymphangiogenic factor contributing to tumor dissemination PMID: 25772247
22. Studies reveal that growth hormone (GH)increases TGFBI expression in a mouse and rat models of diabetic nephropathy (DN) which correlate with clinical results, and suggest that this mechanism can explain the podocytes depletion in DN. PMID: 25740786
23. the functional role of H3K4me in TGFbeta1-mediated TGFBIp and ECM gene expression in corneal fibroblasts PMID: 26553048
24. 19 novel TGFB1 regulatory region and exon 1 alleles are presented: p018-p036. p018, p019, and p020 are formed by novel combinations of known polymorphic positions. Another 16 novel alleles are shown to carry additional known and unknown SNPs. PMID: 25808355
25. The p. Arg555Trp mutation of the TGFBI gene was associated with Thiel-Behnke corneal dystrophy, which revealed a novel phenotype-genotype correlation within the mutational spectrum of phenotypically diverse corneal dystrophies. PMID: 26464103
26. that locally generated TGFBIp at either wounds or tumor sites may contribute to differentiation and angiogenic function of endothelial progenitor cells by augmenting the recruitment of endothelial progenitor cells PMID: 25786978
27. TGFBI functions as a promoter of certain gastrointestinal tract cancers. PMID: 25889002
28. The s present a unilateral variant of late-onset LCD with a heterozygous Pro501Thr mutation in the TGFBI gene. PMID: 23884333
29. insights on TGFBIp trafficking PMID: 25853243
30. TGFBI plays an important role in the progression of colorectal cancers PMID: 25755764
31. Betaig-h3 protein expressed distinctly in gastric cancer peritoneal metastasis. PMID: 25864756
32. The results support a novel inflammatory pathway for diabetic retinopathy. This pathway is initiated by TGFbeta released from macrophages, which promotes synthesis and release of BIGH3 protein by REC and REC apoptosis. PMID: 25378215
33. Silencing of DDR1 inhibited tumor cell growth and motility, and induced TGFBI expression, both in vitro and in vivo. PMID: 25369402
34. A de novo R124C mutation of the TGFBI gene may occur in one of dizygotic twins. Patients with an R124C mutation may have clinical features like corneal dystrophy of the Bowman layer. PMID: 25785536
35. The patient in this reprot showed typical asymmetric ndulinear stromal opacity in both corneas, and an L527R mutation in the TGFBI gene with two SNP mutations. PMID: 24505203
36. We present the characteristics and surgical treatment of corneas with a novel A620P mutation in TGFBI showing lattice corneal dystrophy type IIIA with hyaline component. PMID: 25321938
37. Granular corneal dystrophy type II can co-exist with keratoconus and should be included in the differential diagnosis. PMID: 24582869
38. TGFBI is a potential risk gene for human diabetes. PMID: 24728038
39. a small difference in thermodynamic stability introduced by the P551Q mutation most likely causes structural changes of TGFBIp. PMID: 24302499
40. The TGFBI gene, that is responsible for lattice corneal dystrophy type 1, is expressed above all by the corneal epithelial cells but also by the keratocytes PMID: 25055147
41. Integrins alphavbeta5 and alphavbeta3 both control myofibroblast differentiation by activating latent TGF-beta1 PMID: 24639195
42. These results reveal betaig-h3 enhances the metastasis potentials of human osteosarcoma cells via integrin alpha2beta1-mediated PI3K/AKT signal pathways. PMID: 24595049
43. This study improves the knowledge of the genetic features of Mexican patients with corneal stromal dystrophies by identifying mutations in the TGFBI, CHST6, and GSN genes. PMID: 24801599
44. Pin1 induction during liver fibrosis is involved in hepatic stellate cell activation, TGFbeta1 expression, and TGFbeta1-mediated fibrogenesis signalling. PMID: 24530597
45. The H19-miR-675 axis acts as a suppressor of prostate cancer metastasis via modulation of TGFBI expression. PMID: 24988946
46. Induced BIGH3 expression upon BM stress may contribute to the regulation of BM homeostasis PMID: 24152593
47. A novel heterozygous missense mutation p.Leu565Pro was identified in exon 13 of the TGFBI gene. PMID: 24473223
48. TGFBI dysregulation could occur in HBV-related HCC development. PMID: 24662304
49. TGFBI is required for melanoma metastatic outgrowth; knockdown does not interfere with melanoma cells' dissemination to the lung PMID: 24499734
50. Circulating levels of TGFBIp were significantly elevated in septic patients compared with healthy controls, and were strongly correlated with disease severity. TGFBIp enhanced vascular proinflammatory responses through interacting with integrin alphavbeta5. PMID: 24506343

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HGNC: 11771

OMIM: 121820

KEGG: hsa:7045

STRING: 9606.ENSP00000416330

UniGene: Hs.369397