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  4. Recombinant Human Transducin-like enhancer protein 6 (TLE6)

Recombinant Human Transducin-like enhancer protein 6 (TLE6)

  • 中文名称：
    人TLE6重组蛋白
  • 货号：
    CSB-YP872514HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人TLE6重组蛋白
  • 货号：
    CSB-EP872514HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人TLE6重组蛋白
  • 货号：
    CSB-EP872514HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人TLE6重组蛋白
  • 货号：
    CSB-BP872514HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人TLE6重组蛋白
  • 货号：
    CSB-MP872514HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    TLE6
  • Uniprot No.：
  • 别名：
    TLE6; Transducin-like enhancer protein 6
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-572
  • 氨基酸序列
    MTSRDQPRPK GPPKSTSPCP GISNSESSPT LNYQGILNRL KQFPRFSPHF AAELESIYYS LHKIQQDVAE HHKQIGNVLQ IVESCSQLQG FQSEEVSPAE PASPGTPQQV KDKTLQESSF EDIMATRSSD WLRRPLGEDN QPETQLFWDK EPWFWHDTLT EQLWRIFAGV HDEKAKPRDR QQAPGLGQES KAPGSCDPGT DPCPEDASTP RPPEASSSPP EGSQDRNTSW GVVQEPPGRA SRFLQSISWD PEDFEDAWKR PDALPGQSKR LAVPCKLEKM RILAHGELVL ATAISSFTRH VFTCGRRGIK VWSLTGQVAE DRFPESHLPI QTPGAFLRTC LLSSNSRSLL TGGYNLASVS VWDLAAPSLH VKEQLPCAGL NCQALDANLD ANLAFASFTS GVVRIWDLRD QSVVRDLKGY PDGVKSIVVK GYNIWTGGPD ACLRCWDQRT IMKPLEYQFK SQIMSLSHSP QEDWVLLGMA NGQQWLQSTS GSQRHMVGQK DSVILSVKFS PFGQWWASVG MDDFLGVYSM PAGTKVFEVP EMSPVTCCDV SSNNRLVVTG SGEHASVYQI TY
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Regulates spermatogonia proliferation and cell cycle progression, potentially via regulation of cell cycle regulatory genes such as; CEBPB, CEBPA, CSF3, PCNA, and CDK4. Suppresses FOXG1/BF-1-mediated transcriptional repression by inhibiting interaction of the transcriptional corepressor TLE1 with FOXG1 which promotes cortical neuron differentiation. Acts as a transcriptional corepressor of NFATC1-mediated gene expression by contributing to PAX6-mediated repression.; As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics. Required for the formation of F-actin cytoplasmic lattices in oocytes which in turn are responsible for symmetric division of zygotes via the regulation of mitotic spindle formation and positioning.
  • 基因功能参考文献：
    1. In this first report of a human defect in a member of the subcortical maternal subcritical maternal complex, we show that the TLE6 mutation is gender-specific and leads to the earliest known human embryonic lethality phenotype PMID: 26537248
    2. transcriptional programmes regulated by FOXG1 and Groucho/TLE are important for BTIC-initiated brain tumour growth, implicating FOXG1 and Groucho/TLE in GBM tumourigenesis PMID: 24356439
    3. Expression of Tle6-like in colon cancer cells increased cell proliferation, colony-formation, cell migration, and xenograft tumorgenicity. PMID: 18551179
  • 相关疾病：
    Preimplantation embryonic lethality 1 (PREMBL1)
  • 亚细胞定位：
    Nucleus.; [Isoform 1]: Cytoplasm.; [Isoform 2]: Cytoplasm.
  • 蛋白家族：
    WD repeat Groucho/TLE family
  • 数据库链接：

    HGNC: 30788

    OMIM: 612399

    KEGG: hsa:79816

    STRING: 9606.ENSP00000246112

    UniGene: Hs.334507