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  4. Recombinant Human Transcriptional repressor p66-beta (GATAD2B)

Recombinant Human Transcriptional repressor p66-beta (GATAD2B)

  • 中文名称：
    人GATAD2B重组蛋白
  • 货号：
    CSB-YP823905HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人GATAD2B重组蛋白
  • 货号：
    CSB-EP823905HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人GATAD2B重组蛋白
  • 货号：
    CSB-EP823905HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人GATAD2B重组蛋白
  • 货号：
    CSB-BP823905HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人GATAD2B重组蛋白
  • 货号：
    CSB-MP823905HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    GATAD2B
  • Uniprot No.：
  • 别名：
    FLJ37346; GATA zinc finger domain containing 2B; GATA zinc finger domain containing protein 2B ; GATA zinc finger domain-containing protein 2B; GATAD2B; KIAA1150; MGC138257; MGC138285; mKIAA1150; p66/p68; P66B_HUMAN; P66beta; RGD1308533; transcription repressor p66 beta component of the MeCP1 complex; Transcriptional repressor p66 beta; Transcriptional repressor p66-beta
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-593
  • 氨基酸序列
    MDRMTEDALR LNLLKRSLDP ADERDDVLAK RLKMEGHEAM ERLKMLALLK RKDLANLEVP HELPTKQDGS GVKGYEEKLN GNLRPHGDNR TAGRPGKENI NDEPVDMSAR RSEPERGRLT PSPDIIVLSD NEASSPRSSS RMEERLKAAN LEMFKGKGIE ERQQLIKQLR DELRLEEARL VLLKKLRQSQ LQKENVVQKT PVVQNAASIV QPSPAHVGQQ GLSKLPSRPG AQGVEPQNLR TLQGHSVIRS ATNTTLPHML MSQRVIAPNP AQLQGQRGPP KPGLVRTTTP NMNPAINYQP QSSSSVPCQR TTSSAIYMNL ASHIQPGTVN RVSSPLPSPS AMTDAANSQA AAKLALRKQL EKTLLEIPPP KPPAPLLHFL PSAANSEFIY MVGLEEVVQS VIDSQGKSCA SLLRVEPFVC AQCRTDFTPH WKQEKNGKIL CEQCMTSNQK KALKAEHTNR LKNAFVKALQ QEQEIEQRLQ QQAALSPTTA PAVSSVSKQE TIMRHHTLRQ APQPQSSLQR GIPTSARSML SNFAQAPQLS VPGGLLGMPG VNIAYLNTGI GGHKGPSLAD RQREYLLDMI PPRSISQSIS GQK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2A. Targets MBD3 to discrete loci in the nucleus. May play a role in synapse development.
  • 基因功能参考文献：
    1. GATAD2B interacts with C-MYC to enhance KRAS driven tumor growth. PMID: 30013058
    2. This data suggests that 1q21.3 microdeletion is a recurrent microdeletion syndrome with distinguishable phenotypes, and loss of function of GATAD2B is the major contributor of the characteristic facies and ID. PMID: 28211977
    3. findings suggest that GATAD2B serves as an important mediator of progesterone-progesterone receptor suppression of proinflammatory and contractile genes during pregnancy; decreased GATAD2B expression near term may contribute to the decline in progesterone receptor function, leading to labor PMID: 28576827
    4. This is the first report of GATAD2B in Chinese ID patients. Our findings will broaden the spectrum of GATAD2B mutations and facilitate genetic diagnosis and counseling. PMID: 28077840
    5. p66beta might be important for the regulation of LOX in the nucleus. PMID: 25118846
    6. Detailed clinical description showed that all four individuals with a GATAD2B aberration had a distinctive phenotype with childhood hypotonia, severe intellectual disability. PMID: 23644463
    7. identification as potent transcriptional repressors interacting with MBD2 and MBD3 PMID: 12183469

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  • 相关疾病：
    Mental retardation, autosomal dominant 18 (MRD18)
  • 亚细胞定位：
    Nucleus speckle.
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 30778

    OMIM: 614998

    KEGG: hsa:57459

    STRING: 9606.ENSP00000357644

    UniGene: Hs.4779