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  4. Recombinant Human Transcription factor SOX-3 (SOX3)

Recombinant Human Transcription factor SOX-3 (SOX3)

  • 货号：
    CSB-YP022429HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP022429HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP022429HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP022429HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP022429HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SOX3
  • Uniprot No.：
  • 别名：
    GHDX; MRGH; PHP; PHPX; sox3; SOX3_HUMAN; SOXB; SRY (sex determining region Y)-box 3; SRY Box 3; SRY-related HMG-box gene 3; Transcription factor Sox-3
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-446
  • 氨基酸序列
    MRPVRENSSG ARSPRVPADL ARSILISLPF PPDSLAHRPP SSAPTESQGL FTVAAPAPGA PSPPATLAHL LPAPAMYSLL ETELKNPVGT PTQAAGTGGP AAPGGAGKSS ANAAGGANSG GGSSGGASGG GGGTDQDRVK RPMNAFMVWS RGQRRKMALE NPKMHNSEIS KRLGADWKLL TDAEKRPFID EAKRLRAVHM KEYPDYKYRP RRKTKTLLKK DKYSLPSGLL PPGAAAAAAA AAAAAAAASS PVGVGQRLDT YTHVNGWANG AYSLVQEQLG YAQPPSMSSP PPPPALPPMH RYDMAGLQYS PMMPPGAQSY MNVAAAAAAA SGYGGMAPSA TAAAAAAYGQ QPATAAAAAA AAAAMSLGPM GSVVKSEPSS PPPAIASHSQ RACLGDLRDM ISMYLPPGGD AADAASPLPG GRLHGVHQHY QGAGTAVNGT VPLTHI
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor required during the formation of the hypothalamo-pituitary axis. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Required also within the pharyngeal epithelia for craniofacial morphogenesis. Controls a genetic switch in male development. Is necessary for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells.
  • 基因功能参考文献：
    1. Pathogenic missense mutation in SOX3 gene is associated with intellectual disability, microphthalmia, coloboma, hypopituitarism, facial dysmorphology and dental anomalies, including microcephaly, retrognathia and a solitary median maxillary central incisor amongst other features. PMID: 29175558
    2. our data indicate that SOX3 may serve as an oncogene in osteosarcoma PMID: 29484385
    3. deletion of the SOX3 gene may have a role in intellectual disability with hemophilia B PMID: 27477789
    4. Results show that SOX3 is upregulated in human osteosarcoma (OS) tissues and provide evidence that SOX3 promotes migration, invasiveness, and EMT in OS cells via transcriptional activation of Snail1 expression. PMID: 28335789
    5. we provide a first map of the epigenetic landscape of SOX3 in pluripotent cells and during the early phases of neural differentiation. We found SOX3 gene to be non methylated from undifferentiated NT2/D1 to cells committed towards neural lineage. PMID: 28886103
    6. These findings demonstrate the novel mechanism by which Sox3 contributes to endometrial cancer stem cell invasion and suggest that repression of Sox3 by microRNA-194 may have therapeutic potential to suppress endometrial carcinoma metastasis. The cancer stem cell marker, CD133, might be the surface marker of endometrial cancer stem cell. PMID: 28618953
    7. Data indicate that SRY-box 3 transcription factor SOX-3 targets Src kinase in epithelial ovarian cancer (EOC) cells. PMID: 27251670
    8. SOX3 overdosage permits normal sex development in 46,XX individuals with random X inactivation. PMID: 25791725
    9. Translocations interrupting this region may also affect the gonadal development, possibly depending on the chromatin context of the recipient chromosome. SOX3 duplications may substitute SRY in some XX subjects PMID: 25351776
    10. Screening for SOX3 should be advised not only for hypopituitary patients with an ectopic posterior pituitary, but also for those with a structurally normal pituitary PMID: 25140394
    11. Our study provides additional evidence that deletion in polyalanine tracts of SOX3 is associated with hypopituitarism PMID: 24346842
    12. SOX3 duplication is a genetic cause for XH but has incomplete penetrance. Moreover, increased SOX3 levels may be a risk factor for NTD and potentially other clinical characteristics. PMID: 24737742
    13. the results point at CREB as a positive regulator of SOX3 gene transcription in NT2/D1 cells, while its contribution to RA induction of SOX3 promoter is not prominent. PMID: 24257117
    14. Overexpression of Sox3 is associated with esophageal squamous cell carcinoma. PMID: 23238694
    15. Data indicate that HESX1, LHX4 and SOX3 polymorphisms may be associated with pituitary stalk interruption syndrome (PSIS). PMID: 23199197
    16. TGIF (TG-interacting factor) is an additional TALE superfamily member involved in the regulation of human SOX3 gene expression PMID: 22293114
    17. these results strongly support the pathogenicity of the identified insertions near SOX3 and establish X-linked congenital hypertrichosis syndrome as a genomic disorder. PMID: 21636067
    18. identified genomic rearrangements within the SOX3 regulatory region in three patients with XX male sex reversal PMID: 21183788
    19. SRY is a hybrid of DGCR8 and SOX3, and is regulated by the transcription factor CP2. PMID: 19902333
    20. Data demonstrated that overexpressed PBX1 and MEIS1 increased endogenous SOX3 protein expression in both uninduced and RA-induced NT2/D1 cells. PMID: 19799567
    21. Transcription factor SOX3 is involved in X-linked mental retardation with growth hormone deficiency PMID: 12428212
    22. ... mechanisms underlying X-linked hypopituitarism are...being unravelled, with involvement of SOX3 in a pedigree with X-linked mental retardation ...isol. growth hormone defic., and PHF6 in two siblings with Borjeson-F-Leahmann syndrome. p. 1208 PMID: 14714741
    23. Three nucleotide substitutions (609 T-->C, 732 A-->C, and 978 G-->A) were identified, none of which altered the amino acid sequence, suggesting that they are polymorphic variants. PMID: 15292361
    24. Interestingly, all X linked hypopituitarism duplications contain SOX3 PMID: 15342697
    25. SUMO-1 represses transcriptional activity of SOX3. PMID: 15788563
    26. We conclude that both over- and underdosage of SOX3 are associated with similar phenotypes, consisting of infundibular hypoplasia and hypopituitarism but not necessarily MR. PMID: 15800844
    27. liganded RXRalpha is a potent activator of endogenous SOX3 protein expression PMID: 17005281
    28. Deregulation of SOX3 target genes may contribute to dysfunction of the hypothalamic-pituitary axis in X-linked Hypopituitarism patients. PMID: 17127446
    29. Mutation by deletion of a polyalanine tract does not segregate with mental retardation. PMID: 17627381
    30. Our data indicate that multiple CCAAT control elements are involved in the regulation of the SOX3 promoter, suggesting that NF-Y functions as a key regulator of SOX3 gene expression. PMID: 17910945
    31. of the Xq27.1 breakpoint localized it to a 90 kb interval 3' of the SOX3 gene, supporting a novel role of SOX3 misexpression in the development of Peters anomaly of the eye PMID: 17994562

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  • 相关疾病：
    Panhypopituitarism X-linked (PHPX); Mental retardation, X-linked, with isolated growth hormone deficiency (MRXGH); 46,XX sex reversal 3 (SRXX3)
  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 11199

    OMIM: 300123

    KEGG: hsa:6658

    STRING: 9606.ENSP00000359567

    UniGene: Hs.157429