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  4. Recombinant Human Transcription factor AP-2 gamma (TFAP2C)

Recombinant Human Transcription factor AP-2 gamma (TFAP2C)

  • 货号：
    CSB-YP842150HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP842150HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP842150HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP842150HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP842150HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    TFAP2C
  • Uniprot No.：
  • 别名：
    Activating enhancer binding protein 2 gamma; Activating enhancer-binding protein 2 gamma; AP2-gamma; AP2C_HUMAN; AP2g; AP2gamma; ERF 1; ERF1; Estrogen receptor factor 1; hAP 2g; hAP2g; TFAP 2C; TFAP 2G; Tfap2c; TFAP2G; Transcription factor AP 2 gamma (activating enhancer binding protein 2 gamma); Transcription factor AP 2 gamma; Transcription factor AP-2 gamma; Transcription factor ERF 1; Transcription factor ERF-1; Transcription factor ERF1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-450
  • 氨基酸序列
    MLWKITDNVK YEEDCEDRHD GSSNGNPRVP HLSSAGQHLY SPAPPLSHTG VAEYQPPPYF PPPYQQLAYS QSADPYSHLG EAYAAAINPL HQPAPTGSQQ QAWPGRQSQE GAGLPSHHGR PAGLLPHLSG LEAGAVSARR DAYRRSDLLL PHAHALDAAG LAENLGLHDM PHQMDEVQNV DDQHLLLHDQ TVIRKGPISM TKNPLNLPCQ KELVGAVMNP TEVFCSVPGR LSLLSSTSKY KVTVAEVQRR LSPPECLNAS LLGGVLRRAK SKNGGRSLRE KLDKIGLNLP AGRRKAAHVT LLTSLVEGEA VHLARDFAYV CEAEFPSKPV AEYLTRPHLG GRNEMAARKN MLLAAQQLCK EFTELLSQDR TPHGTSRLAP VLETNIQNCL SHFSLITHGF GSQAICAAVS ALQNYIKEAL IVIDKSYMNP GDQSPADSNK TLEKMEKHRK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
  • 基因功能参考文献：
    1. Study discovered a novel enhancer HER2 gene body enhancer (HGE) in the 3' gene body of HER2. The HGE activates promoters 1 and 2 in trans., and hence the TFAP2C-mediated transcriptional induction of HER2 expression in breast cancer samples. PMID: 29035388
    2. This study shows that TFAP2C promoted lung tumor progression by upregulation of TGFBR1 and consequent activation of PAK1 signaling. PMID: 27885255
    3. miR-137 is a Slug-induced miRNA that relays the pro-metastatic effects of Slug by targeting TFAP2C in non-small cell lung cancer cells. PMID: 28610956
    4. TFAP2C might increase oncogenic miR-183 expression and consequently downregulate tumor-suppressive AKAP12 and decrease tumor-suppressive miR-33a expression and subsequently induce CDK6 in NSCLC cells. PMID: 27593936
    5. Higher TFAP2C protein expression correlates with poor overall survival after 10 years of diagnosis in ERalpha-positive breast cancer. PMID: 26160249
    6. In all three groups[preeclamptic placentas , healthy control and smokers] expression rates of AP-2gamma did not differ between primary, secondary and tertiary villi. PMID: 25315380
    7. TFAP2C has an important role in regulated luminal-specific genes and may be a viable therapeutic target in breast cancer. PMID: 24469049
    8. ShRNA knockdown of AP-2gamma in neuroblastoma cells results in significant inhibit of cell proliferation. PMID: 24969902
    9. Knockdown of TFAP2C or RET inhibited activation of ERK and AKT in MCF-7 cells. Knockdown of TFAP2C, which controls ER (estrogen receptor) and RET, had a greater effect on cell growth than either RET or ER alone. PMID: 24045439
    10. role for TFAP2C in melanoma via its regulation of ECM1 PMID: 24023917
    11. TFAP2C amplification and overexpression represents a genetic dependency in ERBB2+ve breast cancer. PMID: 23334330
    12. TFAP2C regulates expression of the RET proto-oncogene through five AP-2 regulatory sites in the RET promoter. PMID: 22878616
    13. Results demonstrate that TFAP2C regulates the expression of GPX1, which influences the redox state and sensitivity to oxidative stress induced by peroxides. PMID: 22964634
    14. results substantiate a role for Tcfap2c/ TFAP2C in supporting proliferation and repressing differentiation in cellular compartments representing immature/ progenitor cells.[review] PMID: 22560121
    15. We demonstrated that TFAP-2gamma is one of the transcription factors involved in the HuPAR-2 expression in human villous trophoblast cells. PMID: 22702469
    16. demonstrated that while TFAP2C and Myc can downregulate the CDKN1A promoter independently, KDM5B acts as a corepressor dependent on the other two proteins PMID: 22371483
    17. AP-2gamma is a novel collaborative factor in ERalpha-mediated transcription. PMID: 21572391
    18. miR-214 is highly expressed in human melanomas and the data suggest a critical role for this miRNA in disease progression and the establishment of distant metastases through suppression of TFAP2C. PMID: 21468029
    19. Overexpression of TFAP2C is associated with hormone responsive breast carcinoma. PMID: 20629094
    20. AP-2 gamma and Dlx 3, together with an additional transcription factor(s) that are conserved between humans and mice, are required for trophoblast-specific expression of 3 beta-HSD VI. PMID: 11773066
    21. AP-2gamma is important in regulation of ErbB-3 expression in human mammary epithelial and lung fibroblast cells PMID: 11859873
    22. we have identified a potential trophoblast cell-specific regulatory element located 6 kb upstream of the murine AP-2gamma gene transcription start site, and that Sp1 and Sp3 bind to cis-regulatory elements located in the promoter proximal region PMID: 12801994
    23. AP-2gamma expression in breast cancer cells is induced by oestrogens through binding of the oestrogen receptor to a response element within the 5'-untranslated region. PMID: 14565844
    24. Abundant expression of AP-2gamma is associated with intratubular germ cell neoplasias PMID: 15700319
    25. Expression microarray results in human breast carcinoma cells with forced p53 expression revealed AP-2gamma as a putative transcriptional target of p53. PMID: 16636674
    26. TFAP2C is the key regulator of hormone responsiveness in breast carcinoma cells through the control of multiple pathways of estrogen signaling. TFAP2C regulates the expression of ERalpha directly by binding to the ERalpha promoter. PMID: 17875680
    27. Wwox and Ap2gamma emerge are tumor biomarkers that may be superior to PR and Her2 in predicting tamoxifen response PMID: 17947476
    28. AP2 transcription factors may play decisive pacemaker roles in initiating and coordinating budding and branching processes during formation of the fetal breast anlage PMID: 18042070
    29. Down-modulation of AP-2gamma expression in tumor cells by RNA interference led to enhanced tumor growth and reduced chemotherapy-induced cell death, as well as migration and invasion. PMID: 18443366
    30. Reduced expression levels of nuclear AP2gamma is associated with the pathogenesis of basal-like differentiation in breast cancer. PMID: 19130459
    31. Data show that the combination of increasing chromatin accessibility and inducing TFAP2C provides a more robust activation of the ERalpha gene in ERalpha-negative breast cancer cells. PMID: 19458056
    32. ErbB2, CDH2, HPSE and IGSF11 are identified as AP-2gamma target genes in breast cancer cells. PMID: 19671168
    33. AP-2gamma promotes proliferation in breast tumour cells by direct repression of the CDKN1A gene. PMID: 19798054

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    AP-2 family
  • 数据库链接：

    HGNC: 11744

    OMIM: 601602

    KEGG: hsa:7022

    STRING: 9606.ENSP00000201031

    UniGene: Hs.473152