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  4. Recombinant Human Transcription factor AP-2-beta (TFAP2B)

Recombinant Human Transcription factor AP-2-beta (TFAP2B)

  • 货号：
    CSB-YP852874HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP852874HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP852874HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP852874HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP852874HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    TFAP2B
  • Uniprot No.：
  • 别名：
    Activating enhancer binding protein 2 beta; Activating enhancer-binding protein 2-beta; AP 2B; AP2 B; AP2-beta; AP2B; AP2B_HUMAN; AP2beta; MGC21381; OTTHUMP00000039925; PDA2; TFAP 2B; Tfap2b; Transcription factor AP 2 beta; Transcription factor AP-2-beta; Transcription factor AP2 beta
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-460
  • 氨基酸序列
    MHSPPRDQAA IMLWKLVENV KYEDIYEDRH DGVPSHSSRL SQLGSVSQGP YSSAPPLSHT PSSDFQPPYF PPPYQPLPYH QSQDPYSHVN DPYSLNPLHQ PQQHPWGQRQ RQEVGSEAGS LLPQPRAALP QLSGLDPRRD YHSVRRPDVL LHSAHHGLDA GMGDSLSLHG LGHPGMEDVQ SVEDANNSGM NLLDQSVIKK VPVPPKSVTS LMMNKDGFLG GMSVNTGEVF CSVPGRLSLL SSTSKYKVTV GEVQRRLSPP ECLNASLLGG VLRRAKSKNG GRSLRERLEK IGLNLPAGRR KAANVTLLTS LVEGEAVHLA RDFGYICETE FPAKAVSEYL NRQHTDPSDL HSRKNMLLAT KQLCKEFTDL LAQDRTPIGN SRPSPILEPG IQSCLTHFSL ITHGFGAPAI CAALTALQNY LTEALKGMDK MFLNNTTTNR HTSGEGPGSK TGDKEEKHRK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia.
  • 基因功能参考文献：
    1. Data suggest that expression of TFAP2B in lobular carcinoma in situ and invasive lobular breast cancer is up-regulated as compared to control mammary gland epithelium; TFAP2B appear to be involved in regulation of cell proliferation in these slow-growing breast cancer subtypes. PMID: 29035379
    2. previously, only 10 different pathogenic variants in the TFAP2B gene have been associated with the Char syndrome and patent ductus arteriosus (human gene mutation database subscription). We have thus identified the 11th mutation, namely, c.851T>C, p. Leu284Ser, which cosegregates with the phenotype. PMID: 29683802
    3. study demonstrates that AP-2beta promotes tumor growth and predicts poor prognosis, and may represent a potential therapeutic target for breast cancer. PMID: 29972820
    4. Reduced TFAP2B expression in EC was significantly associated with high grade (OR=2.2 for well, moderate vs. poor), stage (OR=2.5 for I vs. IV), histology (OR=1.8 for serous vs. endometrioid), distant metastasis (OR=2.4 for positive vs. negative) (all p-values<0.05). PMID: 29602546
    5. TFAP2B mutation is associated with tooth abnormalities. PMID: 28381879
    6. AP-2 beta and beta-catenin interact both in vitro through GST pull-down assays and in vivo by co-immunoprecipitation. We further identified the interaction regions to the DNA-binding domain of AP-2 beta and the 1-9 Armadillo repeats of beta-catenin. PMID: 28277615
    7. Single nucleotide polymorphisms (SNP) in angiotensin II receptor, type 1 (AGTR1), transcription factor AP-2 beta (TFAP2B), and tumor necrosis factor receptor-associated factor 1 (TRAF1) have been reported to be associated with the incidence of PDA in preterm infants. PMID: 26615960
    8. results suggest that TFAP2B is playing a vital role in retaining retinoic acid responsiveness and mediating noradrenergic neuronal differentiation in neuroblastoma. PMID: 26598443
    9. The presence of the nine-repeat variant of the TFAP-2beta intron 1 VNTR appears to protect girls with ADHD symptoms from the co-expression of symptoms of depression. PMID: 23824473
    10. The expression of TFAP-2beta mRNA in tissue of patients with endometrial carcinoma was higher than that of normal endometrium. The expression of TFAP-2beta mRNA in endometrial tissue of patients with metabolism syndrome was higher than that of lean ones. PMID: 26189251
    11. TFAP2B overexpression contributes to tumor growth and a poor prognosis of human lung adenocarcinoma through modulation of ERK and VEGF/PEDF signaling. PMID: 24766673
    12. The AP-2beta polymorphism significantly influenced cognitive performance, whereas the MAOA and COMT polymorphisms did not. PMID: 23881096
    13. A haploinsufficiency effect of TFAP2B could be involved in familial isolated patent ductus arteriosus. PMID: 24507797
    14. TFAP2B rs987237 and dietary protein/carbohydrate interacted to modify weight maintenance. PMID: 24081236
    15. genomic GATA4 and TFAP2B missense mutations may be associated with nonfamilial congenital heart disease with diverse clinical phenotypes in patients with congenital heart disease from southern China PMID: 22959235
    16. Under energy restriction, TFAP2B may modify the effect of dietary fat intake on weight loss and waist reduction PMID: 22952648
    17. The findings suggest the lack of involvement of known mutations of TFAP2B with syndromic or nonsyndromic CHDs in Mysore patients PMID: 22199100
    18. TFAP2B mutation should be considered a risk factor for isolated PDA. However, the detailed genetic mechanism underlying nonsyndromic the PDA-causing TFAP2B mutation is yet to be elucidated. PMID: 21643846
    19. This study supports a role of the SLC6A4, DRD4 and TFAP2B genes in the temperament, including a gene-gene interaction between SLC6A4 and TFAP2B. It also provides evidence about an effect of the TFAP2B polymorphism in TFAP2B gene transcription. PMID: 21504541
    20. A novel splice-junction in TFAP-2B gene might lead to hereditary patent ductus arteriosus in a Chinese family. PMID: 21215182
    21. central obesity-associated variants in LYPLAL1, NRXN3, MSRA, and TFAP2B PMID: 21674055
    22. It causes accumulation of neutral fats and causes insulin resistance through exaggerated glucose uptake independent of insulin and induces abnormal adipokine secretion, fat cell enlargement and insulin resistance. PMID: 21766608
    23. Loss of TFAP2B is associated with retinoblastoma. PMID: 20607706
    24. TFAP2B seems to regulate the expression of various adipokines in vivo PMID: 20019683
    25. The present study identifies TFAP2b as a suggestive candidate gene in alcohol dependence. PMID: 19778525
    26. no association between a transcription factor Activating Protein 2beta (AP-2beta) gene variant and schizophrenia PMID: 12270648
    27. AP-2beta intron 2 genotype is associated with low levels of anxiety-related personality traits in women. PMID: 14673213
    28. No association between the AP-2beta genotype and measures of dopamine receptor density, or CSF 5-HIAA concentrations. PMID: 15057523
    29. AP-2beta expression was observed in the low-stage subtypes of renal cell carcinoma, and this transcription factor may be related to early carcinogenesis. PMID: 15245963
    30. No differences are observed in AP-2 beta genotype frequencies between 176 subjects with premenstrual dysphoric disorder (PMDD) and 91 healthy controls. PMID: 15722186
    31. Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus. PMID: 15940393
    32. TFAP2B may contribute to the pathogenesis of type 2 diabetes through regulation of adipocytokine gene expression, and that TFAP2B may be a promising target for treatment or prevention of this disease. PMID: 16373396
    33. Boys and girls with the combination of presence of the short 5-HTTLPR, and homozygosity for the long AP-2beta genotype scored significantly lower on Self-Transcendence and Spiritual Acceptance. PMID: 17123722
    34. Investigators speculate on the possible role of TFAP2B gene on the duplicated segment in the three reported cases of partial trisomy. PMID: 17185054
    35. TFAP2B was validated as direct target gene mediating the anti-apoptotic function of PAX3/FKHR PMID: 17525748
    36. L-PGDS gene expression in TE671 cells was activated by USF1 through the aE-box within intron 4 and cooperatively by AP-2beta in the promoter in a cell-type-specific manner. PMID: 17574780
    37. a potential usefulness of AP-2beta polymorphisms in explaining or predicting central nervous diseases, drug effects and side effects. PMID: 18358611
    38. Novel TFAP2B mutation in nonsyndromic patent ductus arteriosus is reported. PMID: 18752453
    39. Reduction of TFAP2B expression could have a protective effect against future risk of complications associated with decreased insulin sensitivity and central adiposity, such as type 2 diabetes and coronary heart disease. PMID: 19325541
    40. TFAP2B, LYPLAL1 and MSRA are associated with adiposity and fat distribution. PMID: 19557161
    41. AP-2beta directly inhibits adiponectin gene expression by displacing NF-YA and binding to its promoter. PMID: 16954217
    42. Novel TFAP2B mutations causing Char syndrome have a dominant-negative effect and provide a genotype-phenotype correlation. PMID: 11505339

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  • 相关疾病：
    Char syndrome (CHAR); Patent ductus arteriosus 2 (PDA2)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    AP-2 family
  • 数据库链接：

    HGNC: 11743

    OMIM: 169100

    KEGG: hsa:7021

    STRING: 9606.ENSP00000377265

    UniGene: Hs.33102