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  4. Recombinant Human Tetraspanin-1 (TSPAN1), partial

Recombinant Human Tetraspanin-1 (TSPAN1), partial

  • 货号：
    CSB-YP025146HU1
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP025146HU1
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP025146HU1-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP025146HU1
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP025146HU1
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    TSPAN1
  • Uniprot No.：
  • 别名：
    TSPAN1; Tetraspanin-1; Tspan-1; Tetraspan NET-1; Tetraspanin TM4-C
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 基因功能参考文献：
    1. miR4913p is frequently downregulated in OS. miR4913p suppressed OS cell growth and invasion. TSPAN1 was identified to be a novel target of miR4913p. Overexpressed TSPAN1 conferred OS cell growth and invasion. PMID: 28849017
    2. TSPAN1 has a role in prostate cancer progression and is a marker for early biochemical recurrence after radical prostatectomy PMID: 27556508
    3. The present study demonstrated that Tspan1 plays an important role in Pancreatic cancer carcinogenic progression, including migration and invasion. PMID: 26370588
    4. Restoration of TSPAN1 rescued the effects of miR-573 overexpression. Therefore, our findings suggest that the miR-573/TSPAN1 axis is important in the control of gastric carcinogenesis PMID: 26054975
    5. our current data demonstrate that miR-638 functions as a tumor suppressor in human colorectal carcinoma by inhibiting TSPAN1 PMID: 25301729
    6. TSPAN1 was proved to induce migration, and so up-regulation of TSPAN1 by miR-200a may explain why over-expressing miR-200a promotes NSCLC cells migration PMID: 23938385
    7. these data argue against a role for tetraspanin 1 as a genuine mediator of cell surface receptor signalling but rather document a role for tetraspanin 1 in the control of cervical cancer cell motility and invasion. PMID: 23754316
    8. data suggest that the NET-1 gene may play an important role in proliferation, migration and endocytosis in the development and progress of hepatocellular carcinoma PMID: 22378020
    9. Study provided the gene expression profile of HBV-related HCC and presented differential expression patterns of SATB-1, TM4SF-1 and ST-14 between cancerous and noncancerous tissues in patients with HBV-related HCC. PMID: 22088470
    10. These studies demonstrate for the first time that Tspan-1 is an interacting partner with human thiamine transporter-1 and that this interaction affects thiamine transporter-1 stability. PMID: 21836059
    11. TSPAN1 may be another important breast cancer suppressor gene belonging to the tetraspanin superfamily. PMID: 20680643
    12. RNAi-mediated downregulation of TSPAN1 expression significantly inhibits the proliferation and invasion of colon cancer cells in vitro. PMID: 21302622
    13. The overexpression of Tspan-1 was found in HCC tissues, positively correlated with clinical stage and negatively correlated with survival rate. PMID: 20890423
    14. Data show that Tspan-1-EGFP expressed in ovarian carcinoma cells was detected mainly in lysosomes, but also in the plasma membrane and in the ER. PMID: 19508227
    15. Overexpression of NET-1 is associated with undifferentiated squamous cell carcinoma of cervical neoplasms PMID: 12115476
    16. Detection of NET-1 gene expression in liver biopsy may provide useful information about the biological behavior of hepatocellular carcinoma. PMID: 17913940
    17. Overexpression of TSPAN1 and Ki67 was negatively correlated with carcinoma differentiation, and the overexpression of TSPAN1 and CD34 was positively correlated with infiltration and lymph node status of the tumor. PMID: 18822690
    18. describe the generation of Tspan-1-specific antibodies and immunohistochemical staining of different subtypes of ovarian carcinomas that revealed significant differences in Tspan-1 expression that was pronounced in mucinous and endometrioid tumors PMID: 19017553

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  • 亚细胞定位：
    Lysosome membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Tetraspanin (TM4SF) family
  • 数据库链接：

    HGNC: 20657

    OMIM: 613170

    KEGG: hsa:10103

    STRING: 9606.ENSP00000361072

    UniGene: Hs.38972