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  4. Recombinant Human Testis-expressed sequence 19 protein (TEX19)

Recombinant Human Testis-expressed sequence 19 protein (TEX19)

  • 中文名称：
    人TEX19重组蛋白
  • 货号：
    CSB-YP847669HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人TEX19重组蛋白
  • 货号：
    CSB-EP847669HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人TEX19重组蛋白
  • 货号：
    CSB-EP847669HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人TEX19重组蛋白
  • 货号：
    CSB-BP847669HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人TEX19重组蛋白
  • 货号：
    CSB-MP847669HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    TEX19
  • Uniprot No.：
  • 别名：
    TEX19; Testis-expressed protein 19
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-164
  • 氨基酸序列
    MCPPVSMRYE EEGMSYLYAS WMYQLQHGDQ LSICFTCFKA AFLDFKDLLE SEDWEEDNWD PELMEHTEAE SEQEGSSGME LSWGQSPGQP VQGGSEAWGP GTLAAAPEGL EDAGLDPHFV PTELWPQEAV PLGLGLEDAD WTQGLPWRFE ELLTCSHWPS FFPS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Required during spermatogenesis and placenta development, participating in the repression of retrotransposable elements and prevent their mobilization. Collaborates with the Piwi-interacting RNA (piRNA) pathway, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins. Interacts with Piwi proteins and directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Also during spermatogenesis, promotes, with UBR2, SPO11-dependent recombination foci to accumulate and drive robust homologous chromosome synapsis. Interacts with LINE-1 retrotransposon encoded LIRE1, stimulates LIRE1 polyubiquitination, mediated by UBR2, and degradation, inhibiting LINE-1 retrotransposon mobilization.
  • 基因功能参考文献：
    1. TEX19 is required to drive cell proliferation in a range of cancer cell types, possibly mediated via an oncogenic transcript regulation mechanism. TEX19 expression is linked to a poor prognosis for some cancers and collectively these findings indicate that not only can TEX19 expression serve as a novel cancer biomarker PMID: 28446200
    2. TEX19 expression in normal tissue is restricted to human testis. TEX19 mRNA expression was detected in 60 % of bladder cancer samples, whereas 58.20 % were positive for TEXT19 protein expression. Compared to low-grade tumors, TEX19 exhibited increased expression in high-grade tumors, from 53.69 to 77.14 %, respectively. TEX19 was also expressed in all six bladder cancer cell lines. PMID: 26695143
    3. TEX19 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. PMID: 21555518
    4. Tex19 is a mammalian-specific protein duplicated in mouse and rat, renamed Tex19.1 and Tex19.2, whereas only one form is found in human. PMID: 18096721
  • 亚细胞定位：
    Cytoplasm.
  • 组织特异性：
    Expressed in testis. Expressed in undifferentiated embryonic stem cells.
  • 数据库链接：

    HGNC: 33802

    OMIM: 615647

    KEGG: hsa:400629

    UniGene: Hs.231897