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  4. Recombinant Human TNF receptor-associated factor 1 (TRAF1)

Recombinant Human TNF receptor-associated factor 1 (TRAF1)

  • 货号：
    CSB-YP024146HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP024146HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP024146HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP024146HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP024146HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    4732496E14Rik; EBI6; EBV induced protein 6; Epstein-Barr virus-induced protein 6; MGC:10353; Tnf receptor associated factor 1; TNF receptor-associated factor 1; TRAF 1; TRAF1; TRAF1_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-416
  • 氨基酸序列
    MASSSGSSPR PAPDENEFPF GCPPTVCQDP KEPRALCCAG CLSENPRNGE DQICPKCRGE DLQSISPGSR LRTQEKAHPE VAEAGIGCPF AGVGCSFKGS PQSVQEHEVT SQTSHLNLLL GFMKQWKARL GCGLESGPMA LEQNLSDLQL QAAVEVAGDL EVDCYRAPCS ESQEELALQH FMKEKLLAEL EGKLRVFENI VAVLNKEVEA SHLALATSIH QSQLDRERIL SLEQRVVELQ QTLAQKDQAL GKLEQSLRLM EEASFDGTFL WKITNVTRRC HESACGRTVS LFSPAFYTAK YGYKLCLRLY LNGDGTGKRT HLSLFIVIMR GEYDALLPWP FRNKVTFMLL DQNNREHAID AFRPDLSSAS FQRPQSETNV ASGCPLFFPL SKLQSPKHAY VKDDTMFLKC IVETST
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2.
  • 基因功能参考文献：
    1. Results showed that TRAF1 was frequently upregulated in NSCLC tissues compared with adjacent non-cancerous lung tissues. TRAF1 expression was positively associated with NSCLC lymphatic metastasis and histological grade and was negatively associated with overall patient survival. PMID: 29528567
    2. TRAF1, CTGF, and CX3CL1 genes are hypomethylated in osteoarthritis PMID: 28470428
    3. s demonstrated that TRAF1 expression had no significant prognostic value for GBM. PMID: 28926524
    4. TRAF1 functions as a positive regulator of insulin resistance, inflammation, and hepatic steatosis dependent on the activation of ASK1-P38/JNK axis. PMID: 26860405
    5. The structure reveals both similarities and differences with other TRAF family members, which may be functionally relevant to TRAFs. The s also found that the TRAF-N coiled-coil domain of TRAF1 is critical for the trimer formation and stability of the protein. PMID: 27151821
    6. this study reveals an unexpected role for TRAF1 in negatively regulating Toll-like receptor signaling, providing a mechanistic explanation for the increased inflammation seen with a rheumatoid arthritis-associated single-nucleotide polymorphism in the TRAF1 gene PMID: 27893701
    7. H. pylori infection significantly inhibits the cleavage of TRAF1 via a CagA-dependent mechanism, which would increase the relative amounts of full-length TRAF1 and exert an antiapoptotic effect on H. pylori-infected cells. PMID: 28082808
    8. Alleles of rs2416804 in TRAF1 were identified as being linked and associated with carotid intima-media thickness. PMID: 27827325
    9. Molecular basis for TANK recognition by TRAF1 revealed by the crystal structure of TRAF1/TANK complex has been reported. PMID: 28155233
    10. TRAF1 plays a crucial role in the pathogenesis of autoantibodies and may serve as a serologic inflammatory marker of disease activity in rheumatoid arthritis patients. PMID: 27592369
    11. Helicobacter pylori infection induces the overexpression of TRAF1 in gastric epithelial cells. The upregulation of TRAF1 plays an antiapoptotic role in Helicobacte pylori -infected gastric cells and may contribute to the gastric carcinogenesis. PMID: 27060717
    12. The increased serum TRAF-1 may be a useful non-invasive indicator of Renal cell carcinoma (RCC) development. PMID: 25158810
    13. Data suggest that, during B-cell transformation by Epstein-Barr virus, LMP1 (EBV latent membrane protein 1) induces signaling that stimulates Lys63-polyubiquitin chain attachment to TRAF1 (TNF receptor-associated factor 1) in the B-lymphocytes. PMID: 25996949
    14. This study did not replicate the association between PTPRC and the response to anti-TNF treatment in our Southern European population. We found that TRAF1/C5 risk RA variants potentially influence anti-TNF treatment response. PMID: 25834819
    15. Rs2900180 in C5-TRAF1 and linked variants in a 66Kb region were associated with radiographic progression in ACPA-negative RA PMID: 25566937
    16. TRAF1/C5 rs10818488 polymorphism is not a genetic risk factor for acquired aplastic anemia in a Chinese population. PMID: 25500258
    17. TRAF1-ALK translocation contributes to neoplastic phenotype in anaplastic large-cell lymphoma. PMID: 25533804
    18. DNMT3L can address DNMT3A/B to specific sites by directly interacting with TFs that do not directly interact with DNMT3A/B PMID: 24952347
    19. These findings suggest that the rs0818488 in TRAF1/C5 region is not associated with rheumatoid arthritis in Iranian population. PMID: 24338224
    20. genetic polymorphism is associated with rheumatoid arthritis susceptibility in Europeans Read More: http://informahealthcare.com/doi/full/10.3109/08820139.2013.837917 PMID: 24144456
    21. Genetic polymorphism rs10818488 in TRAF1/C5 gene might be associated with rheumatoid arthritis susceptibility. [Meta-analysis] PMID: 24234752
    22. Single nucleotide polymorphism of TRAF1 predicts the clinical response to anti-TNF treatment in Japanese patients with rheumatoid arthritis. PMID: 24321457
    23. The association between rs2900180 and rs3761847 polymorphisms and quality of life variables indicates that TRAF1 is involved in the induction of impaired quality of life in primary biliary cirrhosis. PMID: 23710202
    24. activation of TRAF-2 may be early events in the pathogenesis of inflammatory bowel disease PMID: 23414308
    25. TRAF1.NIK is a central complex linking canonical and non-canonical pathways by disrupting the TRAF2-cIAP2 ubiquitin ligase complex PMID: 23543740
    26. This represents the second independent study correlating rs2900180 at the TRAF1 locus with radiological severity in Rheumatoid Arthritis. PMID: 23242182
    27. The frequency of TRAF1 rs3761847 and rs2900180 polymorphisms did not differ between patients and controls. PMID: 23125866
    28. TRAF1 polymorphism is associated with systemic lupus erythematosus in North Africa group and rheumatoid arthritis in European population. PMID: 23321589
    29. An association was found between the rs10818488 polymorphism of TRAF1-C5 and susceptibility to systemic lupus erythemaosis in Europeans [Meta-analysis] PMID: 22820624
    30. We confirmed the positive association of rs10818488 A allele with rheimatoid arthritis in Tunisia. PMID: 22284611
    31. These findings identify TRAF1 as a potential biomarker of HIV-specific CD8 T cell fitness during the chronic phase of disease and a target for therapy. PMID: 22184633
    32. A genetic association of the TRAF1/C5, C1q, and eNOS gene polymorphism, but not of STAT4 and PTPN22, was found to confer a degree of risk for systemic lupus erythematosus in the Turkish population. PMID: 21968398
    33. TRAF1 polymorphisms contribute to rheumatoid arthritis susceptibility, activity, and severity in an Egyption population. PMID: 22196377
    34. Death domain SXXE/D motifs of TNFR1-death domain are phosphorylated, as is required for stable TNFR1-TRADD complex formation and subsequent activation of NF-kappaB in inflamed mucosa. PMID: 21724995
    35. Significant differences in SNPs rs3761847 and rs7021206 at TRAF1/C5 were observed between the case and control groups, the allelic p-value was 0.0018 with an odds ratio of 1.28 for rs3761847 and 0.005 with an odds ratio of 1.27 for rs7021206. PMID: 21492465
    36. 4-1BBL and TRAF1 in the CD8 T cell response to influenza virus and HIV PMID: 21153322
    37. Interaction of TRAF1 with I-kappa B kinase-2 and TRAF2 is important for regulation of NF-kappa B activity. PMID: 20856938
    38. results point to the involvement of the TRAF1/C5 locus in the aetiology of familial and severe alopecia areata (AA), and provide further support for a shared aetiology between AA and other autoimmune disorders. PMID: 20030635
    39. the human TRAF1 mRNA has an unusually long 5'-UTR that contains internal ribosome entry segment regulating its translation. PMID: 20413583
    40. Genetic markers in the 6q23 region and TRAF1-C5 are associated with rheumatoid arthritis, in particular with positive anti-cyclic citrullinated peptide and rheumatoid factor profile. PMID: 19401279
    41. crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes; biochemical, structural, and cell biological studies on the interaction between TRAF2 and cIAP2 and on the ability of TRAF1 to modulate this interaction PMID: 20385093
    42. A significant association was found for the TRAF1-C5 locus in systemic lupus erythematosis, implying that this region lies in a pathway relevant to multiple autoimmune diseases. PMID: 19433411
    43. Results showed no influence of rs10818488 and rs2900180 TRAF1/C5 gene polymorphisms in susceptibility to and clinical expression of giant cell arteritis. PMID: 19918040
    44. Association of TRAF1-C5 locus with rheumatoid arthritis susceptibility was detected in the Japanese populations with modest magnitude, while no significant association was observed for systemic lupus erythematosus. PMID: 19336421
    45. Study of regulation of TRAF1, which was overexpressed in B-CLL lymphocytes, shows NF-kappaB/Rel activity in B-CLL nuclear extracts bind to TRAF1 promoter elements and regulation is IKK-independent. PMID: 12411322
    46. results suggest that tumor necrosis factor receptor-associated factor 1(TRAF1) exerts regulatory effects on receptor-induced nuclear factor-kappaB activation by targeting inhibitor of kappab kinase complex PMID: 12709429
    47. stoichiometry of TRAF1-TRAF2 heteromeric complexes ((TRAF2)2-TRAF1 versus TRAF2-(TRAF1)2) determines their capability to mediate CD40 signaling but has no major effect on TNF signaling PMID: 14557256
    48. Actinomycin D blocked PMA-mediated TRAF1 expression in colon cancer cells, suggesting induction at the transcriptional level. PMID: 14981539
    49. A constitutive expression of TRAF1, TRAF2, and TANK/I-TRAF in human gliomas was documented PMID: 16304992
    50. the t(11, 18)(q21;q21) translocation creating the c-IAP2.MALT1 fusion protein activates NF-kappaB independently of TRAF1 AND TRAF2 and contributes to human malignancy in the absence of signaling adaptors that might otherwise regulate its activity PMID: 16891304

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  • 数据库链接：

    HGNC: 12031

    OMIM: 601711

    KEGG: hsa:7185

    STRING: 9606.ENSP00000362994

    UniGene: Hs.531251