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  4. Recombinant Human TATA box-binding protein-like protein 1 (TBPL1)

Recombinant Human TATA box-binding protein-like protein 1 (TBPL1)

  • 货号：
    CSB-YP023240HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP023240HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP023240HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP023240HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    TBPL1
  • Uniprot No.：
  • 别名：
    21 kDa TBP-like protein; 21kDa TBP like protein; Second TBP of unique DNA; Second TBP of unique DNA protein; STUD; TATA box binding protein like protein 1; TATA box binding protein-related factor 2; TATA box-binding protein-like protein 1; TATA box-binding protein-related factor 2; TBP like 1; TBP like protein; TBP related factor 2; TBP-like factor; TBP-like protein 1; TBP-related factor 2; TBP-related protein; tbpl1; TBPL1_HUMAN; TLF; TLP; TRF2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-186
  • 氨基酸序列
    MDADSDVALD ILITNVVCVF RTRCHLNLRK IALEGANVIY KRDVGKVLMK LRKPRITATI WSSGKIICTG ATSEEEAKFG ARRLARSLQK LGFQVIFTDF KVVNVLAVCN MPFEIRLPEF TKNNRPHASY EPELHPAVCY RIKSLRATLQ IFSTGSITVT GPNVKAVATA VEQIYPFVFE SRKEIL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box.
  • 基因功能参考文献：
    1. TLP Prevents p53 Degradation through Disrupting the p53-MDM2 Interaction. PMID: 28082682
    2. The interaction of TBP-like protein with TFIIA is essential to suppress proteasome-dependent turnover of TBP-like protein PMID: 27696626
    3. miR18a exhibits a protective role in colorectal cancer (CRC) via inhibiting proliferation, invasion and migration of CRC cells by directly targeting the TBPL1 gene. PMID: 26398009
    4. results suggest that activation of the p21 upstream promoter is mediated by interaction between specific regions of TLP and p53 PMID: 24594805
    5. Western blotting and immunohistochemistry both indicated a higher TBPL1 protein expression level in colorectal cancer tissue. siRNA for TBPL1 transfection obviously slowed down the cell proliferation in both SW-620 and HT-29 cells. PMID: 24870791
    6. TLP mediates p53-governed transcriptional activation of the p21 upstream promoter. PMID: 22511763
    7. Data show that during interphase, endogenous or exogenously expressed TRF2 is located almost exclusively in the nucleolus PMID: 15269281
    8. TLF is a functional regulator of transcription with targets distinct from those of TBP. PMID: 15767669

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    TBP family
  • 组织特异性：
    Ubiquitously expressed, with highest levels in the testis and ovary.
  • 数据库链接：

    HGNC: 11589

    OMIM: 605521

    KEGG: hsa:9519

    STRING: 9606.ENSP00000237264

    UniGene: Hs.486507