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  4. Recombinant Human Synaptosomal-associated protein 25 (SNAP25)

Recombinant Human Synaptosomal-associated protein 25 (SNAP25)

  • 货号：
    CSB-YP021873HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP021873HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP021873HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP021873HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    bA416N4.2; Bdr; CMS18; dJ1068F16.2; FLJ23079; HGNC:11132; MGC105414; MGC139754; Resistance to inhibitors of cholinesterase 4 homolog; RIC 4; RIC-4; RIC4; SEC 9; SEC9; SNAP 25; SNAP; SNAP-25; SNAP-25B; SNAP25; SNP 25; SNP25; SNP25_HUMAN; sp; SUP; Super protein; Synaptosomal associated 25 kDa protein; Synaptosomal associated protein; Synaptosomal associated protein 25; Synaptosomal associated protein 25kDa; Synaptosomal-associated 25 kDa protein; Synaptosomal-associated protein 25; Synaptosomal-associated protein; Synaptosomal-associated protein, 25-KD
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Isoform 2
  • 表达区域：
    1-206
  • 氨基酸序列
    MAEDADMRNELEEMQRRADQLADESLESTRRMLQLVEESKDAGIRTLVMLDEQGEQLDRVEEGMNHINQDMKEAEKNLKDLGKCCGLFICPCNKLKSSDAYKKAWGNNQDGVVASQPARVVDEREQMAISGGFIRRVTNDARENEMDENLEQVSGIIGNLRHMALDMGNEIDTQNRQIDRIMEKADSNKTRIDEANQRATKMLGSG
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells.
  • 基因功能参考文献：
    1. Comparing clinical features of reported patients with SNAP25 mutations, the current patients demonstrated apparently milder clinical features with normal intelligence, and no magnetic resonance imaging abnormality or facial dysmorphism. Our results expand the clinical spectrum of SNAP25 mutations. PMID: 29491473
    2. report some evidence supporting the association of SNAP25 to Attention Deficit/Hyperactivity Disorder PMID: 26941099
    3. Single nucleotide polymorphism in SNAP-25 gene is associated with Attention deficit hyperactivity disorder. PMID: 28512748
    4. Findings indicate that lower SNAP-25 in ventromedial caudate in schizophrenia is primarily due to less SNAP-25A, and that the remaining SNAP-25 is associated with greater protein-protein interaction with syntaxin. The absence of a link to recent treatment effects in the human samples, or to administration of antipsychotic drugs in rats suggests the findings are illness- and not treatment-related. PMID: 26971072
    5. Allelic variation of SNAP25 modulates development and plasticity of the prefrontal-limbic network and a shared genetic vulnerability between Bipolar Disorder and Schizophrenia. PMID: 28972123
    6. SH3BP5, LMO3, and SNAP25 were expressed in diffuse large B-cell lymphoma cells and associated with clinical features. PMID: 27184832
    7. show that FOXC1 regulates the expression of RAB3GAP1, RAB3GAP2 and SNAP25 PMID: 28575017
    8. The results of this study suggested that the polymorphisms rs3746544 and rs1051312 may increase the odds of developing ADHD. PMID: 27380186
    9. study demonstrated that miR-27a and -b, which are widely expressed in host cells, suppress SNAP25 and TXN2 expression through posttranscriptional gene silencing. PMID: 28356525
    10. Data suggest that A-syn (alpha-synuclein) promotes SNARE-dependent vesicle docking; phosphatidylserine (PS) removal from t-SNARE-bearing vesicles causes A-syn to inhibit vesicle docking; PS removal from v-SNARE-bearing vesicles promotes vesicle docking; the C-terminal 45 residues of A-syn are required for promotion of vesicle docking. (Here, t-SNARE is SNAP-25; v-SNARE is VAMP2.) PMID: 28495859
    11. our data indicate that the expression of SNAP25 is crucial for dendrite formation and is associated with the effects of targeted chemotherapy. The detection of SNAP25 expression in MB cells may thus be essential for the chemotherapeutic application of Ara-C. PMID: 28339008
    12. Robust association of the rs3746544 SNP and ASD, in both allele and haplotype-based analyses, was observed in Iranian population. PMID: 27888397
    13. Our results will provide novel evidence to reveal the possible role of SNAP-25 in B[a]P-induced neurotoxicity and may be helpful for searching the potential strategy for the prevention measures against B[a]P neurotoxicity. PMID: 28412278
    14. Our analysis indicated that there is no significant association between none of studied variants in SNAP-25 and ADHD. PMID: 27627841
    15. These results of this study suggested that SNAP25 and NOS1 genotypes influence ADHD symptoms only in adults with ADHD. PMID: 26821215
    16. Snap25 rs363050 (G) allele, which results in a reduced expression of Snap25, is associated with altered glycemic parameters in T2DM possibly because of reduced functionality in the exocytotic machinery leading to suboptimal release of insulin. PMID: 26779543
    17. single nucleotide polymorphisms in either the region of NEUROD6 or SNAP25 were significantly associated with Alzheimer's Disease, in APOE4+ females and APOE4+ males, respectively. PMID: 26395074
    18. Data demonstrate a role for SNAP-25 in controlling PSD-95 clustering and open the possibility that genetic reductions of the protein levels may contribute to the pathology through an effect on postsynaptic function and plasticity. PMID: 25678324
    19. BoNT-A injection, but not Lipotoxin instillation, effectively cleaves SNAP-25 in the suburothelium. PMID: 26241848
    20. The expression of SNAP-25 within the enteric nervous system and its downregulation in DD suggest an essential role in enteric neurotransmission and as a marker for impaired synaptic plasticity in enteric neuropathies. PMID: 25655772
    21. The SNAP-25 Ddel T/C genotype was more common in fibromyalgia syndrome patients compared to controls, and it related to behavioral symptoms, personality and psychological disorders. PMID: 24885975
    22. The rs363050 gene polymorphism correlates with decreasing cognitive scores in autistic children. PMID: 25629685
    23. This study demonstrated that SNAP-25 polymorphisms may be associated with Alzheimer's disease and correlate with alterations in categorical fluency and a reduced localized brain activity. PMID: 25024311
    24. SNARE complex genes and their interactions may play a significant role in susceptibility and working memory of ADHD. PMID: 25445064
    25. Patterns of the immunoreactivity with antibodies to SNAP-25, synapsin-I and synaptophysin are completely appropriate to those of adult's OB on the 38-40 weeks of the prenatal development. PMID: 26204769
    26. The results show that the positively charged amino acids at the SNAP-25 C terminus promote tight SNARE complex zippering and are required for high release frequency and rapid release in individual fusion events. PMID: 25698757
    27. Ile67Asn variant in SNAP25B is pathogenic because it inhibits synaptic vesicle exocytosis PMID: 25381298
    28. Cerebrospinal fluid SNAP-25 differentiated Alzheimer's disease from controls PMID: 25418885
    29. SNPs in SNAP25 represent a common risk factor of both schizophrenia and major depressive disorder in the Han Chinese population. PMID: 25650683
    30. In conclusion,the present results of a family-based association study do not support a strong role of SNARE genes in adult ADHD PMID: 24176595
    31. Full-length SNAP25 is cleaved more efficiently by the protease domain of serotype A botulinum neurotoxin than its shorter fragments. PMID: 24769566
    32. found evidence of the association of SNAP25 and ADHD. PMID: 24362847
    33. no associaton with idiopathic generalized epilepsy was found regarding Intron 7 rs1569061 of Syntaxin 1A gene, MnlI rs3746544 and DdeI rs1051312 polymorphisms of SNAP-25 gene compared with healthy subjects PMID: 24164654
    34. Association of impulsivity and polymorphic microRNA-641 target sites in the SNAP-25 gene. PMID: 24391914
    35. direct interaction between TRIM9 and the Netrin-1 receptor DCC as well as a Netrin-1-sensitive interaction between TRIM9 and the SNARE component SNAP25. The interaction with SNAP25 negatively regulates SNARE-mediated exocytosis and axon PMID: 24778312
    36. A combination of NET1 (rs2242447) and SNAP-25 (rs3746544) is a risk factor for ADHD. PMID: 23872233
    37. DNA variation at SNAP25 confers risk to attention deficit disorder with hyperactivity. PMID: 23593184
    38. Significant associations between two SNPs in the SNAP-25 gene (rs363039 and rs363050) and shyness was found. PMID: 23888754
    39. There was an association between schizophrenia and the SNAP-25 rs1503112 polymorphism found, which survived correction for multiple testing. PMID: 22940547
    40. There was a trend towards the increase in the frequency of an G allele of SNAP-25 in siblings of patients. PMID: 23612411
    41. syntaxin 1 and SNAP-25 cooperate as SNARE proteins to support neuron survival. PMID: 23403573
    42. PRIP inhibits regulated exocytosis through the interaction of its C2 domain with syntaxin 1 and SNAP-25, potentially competing with accessory proteins such as synaptotagmin I and by directly inhibiting trans-SNARE complex formation PMID: 23341457
    43. low IQ group of children has higher frequency of SNAP25 allele, associated with intellectual disability. PMID: 22762387
    44. There was a loss of SNAP-25 in visual cortex in dementia with Lewy bodies compared to controls. PMID: 23242284
    45. no Alzheimer's Disease-associated differences in SNAP25 promoter DNA methylation were observed PMID: 22732502
    46. Data obtained in this preliminary study indicates that rs3746544 'T' SNAP25 allele may have some role in the disease etiology in the studied Indian population PMID: 21996783
    47. SNAP25 might represent the first description of an adaptively evolving gene with a role in cognition. PMID: 22193912
    48. Letter: incubation of pancreatic islets with fibronectin improves beta cell function via increased expression of syntaxin 1 and SNAP25. PMID: 21926557
    49. Forming an acceptor SNARE complex between syntaxin-1A and SNAP-25 weakens but does not abrogate cholesterol-controlled cluster formation and indicates that the reconstitution process results in equal incorporation of protein at either lipid composition. PMID: 21916482
    50. DdeI and MnII T/T genotypes of SNAP25 may be a risk factor for antisocial behavior in a Turkish population. PMID: 21756448

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  • 相关疾病：
    Myasthenic syndrome, congenital, 18 (CMS18)
  • 亚细胞定位：
    Cytoplasm, perinuclear region. Cell membrane; Lipid-anchor. Cell junction, synapse, synaptosome. Photoreceptor inner segment.
  • 蛋白家族：
    SNAP-25 family
  • 组织特异性：
    Neurons of the neocortex, hippocampus, piriform cortex, anterior thalamic nuclei, pontine nuclei, and granule cells of the cerebellum.
  • 数据库链接：

    HGNC: 11132

    OMIM: 600322

    KEGG: hsa:6616

    STRING: 9606.ENSP00000254976

    UniGene: Hs.167317