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  4. Recombinant Human Synapsin-3 (SYN3)

Recombinant Human Synapsin-3 (SYN3)

  • 中文名称：
    人SYN3重组蛋白
  • 货号：
    CSB-YP023004HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SYN3重组蛋白
  • 货号：
    CSB-EP023004HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SYN3重组蛋白
  • 货号：
    CSB-EP023004HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SYN3重组蛋白
  • 货号：
    CSB-BP023004HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SYN3重组蛋白
  • 货号：
    CSB-MP023004HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SYN3
  • Uniprot No.：
  • 别名：
    cN28H9.2 (synapsin III); OTTHUMP00000028987; SYN 3; SYN3; SYN3_HUMAN; Synapsin 3; Synapsin III; Synapsin-3
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-580
  • 氨基酸序列
    MNFLRRRLSD SSFMANLPNG YMTDLQRPDS STSSPASPAM ERRHPQPLAA SFSSPGSSLF SSLSSAMKQA PQATSGLMEP PGPSTPIVQR PRILLVIDDA HTDWSKYFHG KKVNGEIEIR VEQAEFSELN LAAYVTGGCM VDMQVVRNGT KVVSRSFKPD FILVRQHAYS MALGEDYRSL VIGLQYGGLP AVNSLYSVYN FCSKPWVFSQ LIKIFHSLGP EKFPLVEQTF FPNHKPMVTA PHFPVVVKLG HAHAGMGKIK VENQLDFQDI TSVVAMAKTY ATTEAFIDSK YDIRIQKIGS NYKAYMRTSI SGNWKANTGS AMLEQVAMTE RYRLWVDSCS EMFGGLDICA VKAVHSKDGR DYIIEVMDSS MPLIGEHVEE DRQLMADLVV SKMSQLPMPG GTAPSPLRPW APQIKSAKSP GQAQLGPQLG QPQPRPPPQG GPRQAQSPQP QRSGSPSQQR LSPQGQQPLS PQSGSPQQQR SPGSPQLSRA SSGSSPNQAS KPGATLASQP RPPVQGRSTS QQGEESKKPA PPHPHLNKSQ SLTNSLSTSD TSQRGTPSED EAKAETIRNL RKSFASLFSD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be involved in the regulation of neurotransmitter release and synaptogenesis.
  • 基因功能参考文献：
    1. These findings contribute to previous work showing dysregulation of Synapsins, particularly SYN2, in mood disorders and improve our understanding of the regulatory mechanisms that precipitate these changes likely leading to the BD or MDD phenotype. PMID: 27515700
    2. Syn-3 may mimic Syn-1A in the ability to bind and modulate Cavs, but preferring Cav2.3 to perhaps participate in triggering fusion of newcomer insulin SGs during second-phase GSIS. PMID: 26848587
    3. These findings support a reciprocal modulatory interaction of alpha-syn and synapsin III in the regulation of dopamine neuron synaptic function. PMID: 25967550
    4. The variations of MnSOD (rs4880) and SYN III (rs3788470, rs3827336, rs5998557) were not major risk factors for PD among Chinese, at least in our study populations PMID: 24586301
    5. A significant difference was determined between attention deficit hyperactivity disorder and synapsin III gene -631 C>G polymorphism compared to the control group. PMID: 23768104
    6. Evidence is not in favor of a large effect of synapsin III gene in the pathogenesis of schizophrenia. PMID: 11840510
    7. A missense polymorphism, S470N, was identified in the synapsin III gene and appeared more frequently in individuals with schizophrenia. The site affected by the polymorphism, Ser470, was determined to be a substrate for mitogen-activated protein kinase. PMID: 14732590
    8. Supports a role for synapsin III in a subset of African American patients with schizophrenia. PMID: 15900227
    9. A trend towards significance was detected when the synapsin III -196A allele distribution was analyzed in Caucasian patients with schizophrenia and a cohort of subjects from the Czech Republic with bipolar disorder. PMID: 16511335
    10. No evidence that the synapsin III locus as a major susceptibility locus contributing to attention deficit hyperactivity disorder. PMID: 17413450
    11. the C/C genotype in rs133946 and the G/G genotype in rs133945 could be protecting factors against multiple sclerosis in the Basque population. PMID: 18755822
    12. The variation in SYN III methylation studied is 1) not related to schizophrenia in the population sample or a monozygotic twin pair discordant for schizophrenia and 2) not related to the mRNA level of SYN IIIa in different human brain regions PMID: 19102774
    13. Both the association studies and expression studies didn't support a major role for SYN3 in the susceptibility of schizophrenia in Irish and Chinese populations. PMID: 19766700

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  • 亚细胞定位：
    Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Peripheral membrane protein localized to the cytoplasmic surface of synaptic vesicles.
  • 蛋白家族：
    Synapsin family
  • 组织特异性：
    Neuron specific. Detected predominantly in brain.
  • 数据库链接：

    HGNC: 11496

    OMIM: 602705

    KEGG: hsa:8224

    STRING: 9606.ENSP00000330219

    UniGene: Hs.608750