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  4. Recombinant Human Suppressor of cytokine signaling 1 (SOCS1)

Recombinant Human Suppressor of cytokine signaling 1 (SOCS1)

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  • 货号：
    CSB-EP022388HU
  • 规格：
    ￥1344
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP022388HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) SOCS1.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP022388HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) SOCS1.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 别名：
    CISH 1; CISH1; Cytokine inducible SH2 protein 1; JAB; JAK binding protein; JAK-binding protein; Janus kinase binding protein ; SOCS 1; SOCS-1; Socs1; SOCS1_HUMAN; SSI 1; SSI-1; SSI1; STAT induced STAT inhibitor 1; STAT-induced STAT inhibitor 1; Suppressor of cytokine signaling 1; Supressor of cytokine signalling 1; TEC interacting protein 3; Tec-interacting protein 3; TIP 3; TIP-3; TIP3
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length
  • 来源：
    E.coli
  • 分子量：
    27.6kDa
  • 表达区域：
    1-211aa
  • 氨基酸序列
    MVAHNQVAADNAVSTAAEPRRRPEPSSSSSSSPAAPARPRPCPAVPAPAPGDTHFRTFRSHADYRRITRASALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRESFDCLFELLEHYVAAPRRMLGAPLRQRRVRPLQELCRQRIVATVGRENLARIPLNPVLRDYLSSFPFQI
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 产品描述：

    The preparation of this recombinant Human SOCS1 protein was to use gene recombination DNA technology to obtain a recombinant vector connected with a SOCS1 fragment (1-211aa) that could be translated into the SOCS1 protein and then transferred it into E.coli cells to express the recombinant SOCS1 protein molecule. In order to get the target protein with high purity, N-terminal 6xHis tag was used in the production. The purity is 90% determined by SDS-PAGE.

    SOCS1 is a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. It is highly conserved among various species, including human, chimpanzee, dog, cow, rat and chicken. SOCS1 was also involved in E3 ubiquitin ligases complex, acting as substrate-recognition modules to mediate the polyubiquitination and subsequent degradation of substrate proteins which may be the key components of cytokine signal transduction pathways. Both two functions of SOC1 are very important to regulate the growth and proliferation of cell. Therefore, numerous studies have speculated that SOCS1 may play a role in regulating tumor growth and proliferation, such as hepatocellular carcinoma, melanoma, gastric cancer, prostate cancer and so on.

  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Through binding to JAKs and IFNGR1, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.
  • 基因功能参考文献：
    1. High SOCS1 expression is associated with higher grade breast cancer. PMID: 30453988
    2. SOCS1 gene methylation caused gene silencing of SOCS1. PMID: 29916533
    3. SOCS1 is regulated in prostate cancer cells through miR-221-5p expression. PMID: 29506516
    4. The results indicate SOCS1 plays an important role in AML and its higher expression serves as a new biomarker to risk-stratify AML patients. PMID: 28753595
    5. reveal a vital contribution of miR-155 upregulation and consequent SOCS1 downregulation to an immune response triggered via IFN-gamma in BA PMID: 28355202
    6. Guar gum fiber increases SOCS-1 expression in Caco-2 cells. PMID: 28608623
    7. overexpression of SOCS-1 prevented TNF-alpha-mediated cell oxidative stress and apoptosis in human renal tubular epithelial cells PMID: 28732559
    8. we report here that SOCS1 impacts the pattern of secreted products in cells with active p53 and is required for the expression of a selective set of p53 target genes including those involved in ferroptosis. PMID: 29081404
    9. SOCS1 attenuates migration and invasion properties of hepatocellular carcinoma cells at least partly via modulation of MET-mediated epithelial-mesenchymal transition, and controls invasive tumor growth. PMID: 29085209
    10. Our findings revealed significantly higher rates of insulin resistance, obesity and dyslipidaemia in Turkish patients with polycystic ovary syndrome compared with age-matched healthy controls, while no difference between study groups in terms of the rate of SOCS1-1478 CA/del polymorphism along with no significant relation of SOCS1-1478 CA/del polymorphism to insulin resistance and PCOS status. PMID: 28569589
    11. polymorphisms of the SOCS1 gene are associated with the risk of ischemic stroke in a northern Chinese Han population, suggesting that SOCS1 gene polymorphisms may play an important role in the pathogenesis of ischemic stroke PMID: 27216615
    12. our findings demonstrate that 5-hmC loss is an epigenetic hallmark of hepatocellular carcinoma , and miR-29a is an important epigenetic modifier, promoting HCC metastasis through TET-SOCS1-MMP9 axis silencing. The results offer a new strategy for epigenetic cancer therapy PMID: 28661477
    13. SOCS-1, SOCS-2, and SOCS-3 proteins may directly or indirectly, have important roles in development and pathogenesis of papillary thyroid cancer PMID: 28643757
    14. Report simultaneous over-expression of miR-155 and SOCS1 that may be characteristic for Sjogren's syndrome. PMID: 26620207
    15. SOCS1 inhibits epithelial IL-13 signalling, supporting its key role in regulating Th2-driven eosinophilia in severe asthma PMID: 27338192
    16. SOCS1 antagonizes epithelial-mesenchymal transition by suppressing Src activity, leading to thioredoxin expression and down-regulation of ROS levels in colon cancer cells PMID: 27613835
    17. Our findings support the tumor suppressor role of SOCS1 in PCa and suggest that attenuation of MET signaling is one of the underlying mechanisms. SOCS1 in PCa cells also appears to prevent the tumor-promoting functions of cancer-associated fibroblasts. PMID: 27779203
    18. Findings indicate that miR-21 and miR-155 promote the development of non-small cell lung carcinoma (NSCLC) in part by downregulating three tumor suppressor genes suppressor of cytokine signaling 1 protein (SOCS1), SOCS6, and PTEN. PMID: 27811366
    19. Evaluating SOCS1 and p21 protein expression in prostatectomy specimens may have a prognostic value in identifying the aggressive prostate cancer. Inverse correlation between SOCS1 expression and disease severity was observed. However, SOCS1 expression did not correlate with that of p53, MET or p21 in the whole study cohort. PMID: 28235401
    20. In this study, the s report that JOSD1 plays an important role in regulating type-I interferon (IFN-I)-mediated antiviral activity. JOSD1 physically interacts with SOCS1, which is an essential negative regulator of many cytokines signaling, and enhances SOCS1 stability by deubiquitinating K48-linked polyubiquitination of SOCS1. PMID: 28355105
    21. Co-immunoprecipitation experiments showed that SOCS1 mutations abolished JAK3 binding, revealing a key role for SOCS1 in regulating JAK3/STAT5 signaling PMID: 27144517
    22. C/EBPbeta overexpression or knockdown did not change the levels of IL-1beta-induced SOCS1. SOCS1 regulated the levels of C/EBPbeta mRNA by ubiquitination of C/EBPbeta as well as transcriptional regulation in human chondrocytes. PMID: 27339399
    23. patients with renal graft rejection expressed lower levels of SOCS1 PMID: 27423763
    24. Inhibiting the STAT3-Mcl-1 signaling axis by ectopic SOCS1 improved radiosensitivity by inducing apoptosis and enhancing DNA damage after radiotherapy, offering a mechanistic rationale for a new esophageal squamous cell carcinoma treatment. PMID: 29042418
    25. an overview of the mechanisms underlying SOCS1 function as a tumor suppressor and discuss the emerging evidences of SOCS1 activity as an oncogene. PMID: 26811119
    26. MiRNA sponges against miR-19 or miR-155 inhibit the functions of these miRNAs and potentiate the induction of SOCS1 and p53 in mouse leukemia cells and in human myeloma cells. PMID: 26841929
    27. Mutations of CREBBP and SOCS1 are independent prognostic factors in diffuse large B cell lymphoma; SOCS1 mutations were associated with better progression-free survival. PMID: 28302137
    28. These results suggest that miR146a may regulate SOCS1/STAT3 and cytokine signalling in monocytes, directing T-cell differentiation and balancing immune clearance and immune injury during chronic viral infection. PMID: 27004559
    29. IFN-lambda signaling is regulated by SOCS1 but not by SOCS3 or USP18. PMID: 28900038
    30. This study evaluation the roles of SOCS1, the regulator of TLR9, RIG-I, and CD152 in patients with liver fibrosis/cirrhosis; the use of polymorphisms as markers for genetic risk is reported. PMID: 28762092
    31. SOCS1 rs33932899 genotype was significantly related to severe necroinflammatory activity (NIA) grade of chronic hepatitis C patients. PMID: 28704535
    32. Studies indicate that suppressors of cytokine signaling (SOCS) proteins CIS, SOCS1, and SOCS3 can be considered the third immunocheckpoint molecules since they regulate cytokine signals that control the polarization of CD4(+) T cells and the maturation of CD8(+) T cells. PMID: 28188673
    33. Results provide evidence that repression of SHP-1, SHP-2 and SOCS-1 gene expression in patient plasma cells supports the constitutive activation of the JAK/STAT3 pathway and probably leads to higher degrees of bone marrow invasion. PMID: 28369102
    34. Suppressor of cytokine signaling 1 (SOCS1) expression was upregulated in sustained virological responses (SVR) patients compared with non-SVR patients based on a multiplex reverse transcription-polymerase chain reaction analysis. Peripheral blood SOCS1 expression before treatment was not associated with SVR in hepatitis C virus (HCV) genotype 1 patients treated with pegylated IFN-alpha and ribavirin. PMID: 26786212
    35. tumor-suppressor functions of SOCS1 in the liver could be mediated, at least partly, via regulation of the expression, stability and subcellular distribution of p21 and its paradoxical oncogenic functions, namely, resistance to apoptosis and increased proliferation PMID: 26725321
    36. Suppressor Of Cytokine Signaling 1 (SOCS1) overexpression in retinal pigment epithelium cells inhibits some IFNgamma-mediated responses that lead to uveitis development. This notion raises the possibility that SOCS1 overexpression could be a novel target for treating non-infectious uveitis. PMID: 27478014
    37. nectin-4 serves as a stimulatory co-receptor for the prolactin receptor by regulating the feedback inhibition of SOCS1 in the JAK2-STAT5a signaling pathway PMID: 28258213
    38. This study showed that SOCS5 expression was significantly down-regulated. PMID: 28196747
    39. this study shows that IL-7 induces the expression of SOCS1 through the JAK/STAT-5 pathway PMID: 27423467
    40. SOCS1 silencing can inhibit proliferation and induce apoptosis of MV3 and A357 melanoma cells in vivo and in vitro by inhibiting extracellular signal-regulated kinase and janus kinase signal transduction and activators of transcription signaling pathways. PMID: 28466787
    41. SOCS1 may promote apoptosis of intestinal epithelial cells at least partly through mediating p53 signaling. PMID: 27236107
    42. The results revealed that although the expression levels of SOCS1, SOCS3 and, in particular, pSHP2, tend to decrease in the four types of astrocytomas, PIAS3 downregulation is more negatively correlated with STAT3 activation in the stepwise progress of astrocytomas and would indicate an unfavorable outcome. PMID: 28035384
    43. findings provide novel insight into how dysregulated expression of SOCS increases IL-4 responses in allergic monocytes, and this may represent a new therapeutic avenue for managing allergic disease. PMID: 27507812
    44. Overexpression of SOCS1 has a potent antitumor effect against ESCC. PMID: 28233302
    45. IL-4 signaling plays a crucial role in the regulatory functions of SOCS1 in apoptosis and inflammation in human osteoarthritic chondrocytes. These findings provide a potential therapeutic target for the clinical treatment of osteoarthritis (OA) PMID: 28373981
    46. Through promoter hypermethylation, the SOCS-1 gene was severely down-regulated in the colorectal cancer tissue samples. PMID: 27133036
    47. Reduced SOCS1 protein levels in systemic lupus erythematosus patients are correlated with enhanced STAT1 activation. PMID: 27781323
    48. These data thus suggest that overexpression of SOCS1 and SOCS3 induced by denguevirus infection leads to impairment of antiviral response through the inhibition of STAT functionality. PMID: 26709547
    49. miR-203 and miR-221 regulate SOCS1 and SOCS3 in essential thrombocythemia PMID: 26990535
    50. The HBVX gene upregulated the mRNA and protein expression levels of DNMT3A/3B, downregulated the expression of SOCS1 and increased SOCS1 gene promoter CpG island methylation. PMID: 26573490

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  • 亚细胞定位：
    Nucleus. Cytoplasmic vesicle. Note=Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3.
  • 蛋白家族：
    SOCS1 family
  • 组织特异性：
    Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes.
  • 数据库链接：

    HGNC: 19383

    OMIM: 603597

    KEGG: hsa:8651

    STRING: 9606.ENSP00000329418

    UniGene: Hs.50640