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  4. Recombinant Human Steroid hormone receptor ERR2 (ESRRB)

Recombinant Human Steroid hormone receptor ERR2 (ESRRB)

  • 货号：
    CSB-YP007836HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP007836HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP007836HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP007836HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP007836HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Err 2; ERR b; ERR B2; ERR beta 2; ERR beta; ERR beta-2; ERR-beta; Err2; ERR2_HUMAN; ERRB 2; ERRb; ERRB2; ERRbeta 2; ERRbeta; ESR L2; ESRL 2; ESRL2; Esrrb; Estrogen receptor like 2; Estrogen receptor related 2; Estrogen receptor-like 2; Estrogen-related receptor beta; Estrrb; Nr3b2; Nuclear receptor ERRB2; Nuclear receptor subfamily 3 group B member 2; Orphan nuclear receptor; Steroid hormone receptor ERR 2; Steroid hormone receptor ERR2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-508
  • 氨基酸序列
    MSSDDRHLGS SCGSFIKTEP SSPSSGIDAL SHHSPSGSSD ASGGFGLALG THANGLDSPP MFAGAGLGGT PCRKSYEDCA SGIMEDSAIK CEYMLNAIPK RLCLVCGDIA SGYHYGVASC EACKAFFKRT IQGNIEYSCP ATNECEITKR RRKSCQACRF MKCLKVGMLK EGVRLDRVRG GRQKYKRRLD SESSPYLSLQ ISPPAKKPLT KIVSYLLVAE PDKLYAMPPP GMPEGDIKAL TTLCDLADRE LVVIIGWAKH IPGFSSLSLG DQMSLLQSAW MEILILGIVY RSLPYDDKLV YAEDYIMDEE HSRLAGLLEL YRAILQLVRR YKKLKVEKEE FVTLKALALA NSDSMYIEDL EAVQKLQDLL HEALQDYELS QRHEEPWRTG KLLLTLPLLR QTAAKAVQHF YSVKLQGKVP MHKLFLEMLE AKVGQEQLRG SPKDERMSSH DGKCPFQSAA FTSRDQSNSP GIPNPRPSSP TPLNERGRQI SPSTRTPGGQ GKHLWLTM
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5'TCAAGGTCA-3' localized on promoter and enhancer of targets genes regulating their expression or their transcription activity. Plays a role, in a LIF-independent manner, in maintainance of self-renewal and pluripotency of embryonic and trophoblast stem cells through different signaling pathways including FGF signaling pathway and Wnt signaling pathways. Upon FGF signaling pathway activation, interacts with KDM1A by directly binding to enhancer site of ELF5 and EOMES and activating their transcription leading to self-renewal of trophoblast stem cells. Also regulates expression of multiple rod-specific genes and is required for survival of this cell type. Plays a role as transcription factor activator of GATA6, NR0B1, POU5F1 and PERM1. Plays a role as transcription factor repressor of NFE2L2 transcriptional activity and ESR1 transcriptional activity. During mitosis remains bound to a subset of interphase target genes, including pluripotency regulators, through the canonical ESRRB recognition (ERRE) sequence, leading to their transcriptional activation in early G1 phase. Can coassemble on structured DNA elements with other transcription factors like SOX2, POU5F1, KDM1A and NCOA3 to trigger ESRRB-dependent gene activation. This mechanism, in the case of SOX2 corecruitment prevents the embryonic stem cells (ESCs) to epiblast stem cells (EpiSC) transition through positive regulation of NR0B1 that inhibits the EpiSC transcriptional program. Also plays a role inner ear development by controlling expression of ion channels and transporters and in early placentation.; Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5'TCAAGGTCA-3' localized on promoter and enhancer of targets genes regulating their expression or their transcription activity. Positively regulates ESR1 transcriptional activity upon E2 stimulation.
  • 基因功能参考文献：
    1. the calcium level was associated with genetic variations in AMELX, AMNB and ESRRB. AMELX and AMNB are involved in enamel mineralization. Mutations in both these genes are responsible for the amelogenesis imperfecta phenotype (OMIN), which supports their link with enamel alterations as well as enamel mineralization. PMID: 28395292
    2. SNP (rs61742642; C to T, P386S) in the ligand-binding domain of human estrogen-related receptor beta is associated with audiometric temporary threshold shift. PMID: 27399974
    3. ESRRbeta is mislocalized in human myocardium samples with idiopathic dilated cardiomyopathy, suggesting a possible role for ESRRbeta in the pathogenesis of idiopathic dilated cardiomyopathy in humans PMID: 28130335
    4. The rs1676303 TT (P=0.02) and rs6574293 GG (P=0.04) genotypes of ESRRB were associated with RCD and TMD, respectively. PMID: 26584852
    5. analysis of Esrrb target genes indicates Esrrb may be an important factor in regulating cell proliferation PMID: 26627478
    6. ERRbeta has a role in estrogen-dependent cellular function including cancer cell proliferation PMID: 25805499
    7. The significant association and the presence of high-risk haplotypes identified in the ESRRB gene confirm the association of variants in ESRRB and rotator cuff disease. PMID: 25219474
    8. study concludes ESRRB, a gene when mutated causes a form of hearing impairment, also contributes to dental decay likely by influencing the formation of an enamel surface more susceptible to demineralization under acidic conditions PMID: 25023176
    9. ERRbeta signalling leads to BCAS2-mediated blockage of the G1/S transition and inhibition of the epithelial to mesenchymal transition through FST-mediated regulation of E-cadherin PMID: 24667650
    10. This is the first report of DFNB35 mutations in the Czech Republic and it seems to be a rare cause of non-syndromic hearing loss. PMID: 22951369
    11. A novel missense mutation in the ESRRB gene causes DFNB35 hearing loss in a Tunisian family. PMID: 21802533
    12. Data confirm the up-regulation of ER-beta as the principal receptor involved in the progression of human endometriosis. PMID: 21561608
    13. ERRbeta plays a repressor role in the Nrf2-ARE pathway PMID: 17920186
    14. ERRbeta performs a tumor suppressing function in prostate cancer cells. PMID: 18071305
    15. Data indicate that ESRRB is essential for inner-ear development and function and a frame shift mutation in ESRRB results in non-syndromic hearing impairment. PMID: 18179891
    16. Sequence analysis of the ESRRB gene in the affected individuals of the original DFNB35 family and in three other DFNB35-linked consanguineous families from Pakistan revealed four missense mutations. PMID: 18179891
    17. ERRbeta protein was localized to cell nuclei within multiple endometrial cell types including the glands, stroma, endothelium and immune cells, including uterine natural killer (uNK) cells and macrophages throughout normal menstrual cycle. PMID: 18775884
    18. Esrrb coordinates with Nanog and Oct4 to activate the internal machinery of ES cells PMID: 18957414
    19. Short-form hERRbeta lacks an F domain and is the matched homolog of mouse and rat ERRbeta proteins in human. However, hERRbeta2-Delta10 and the previously reported hERRbeta2 isoforms are primate specific. PMID: 16332939

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  • 相关疾病：
    Deafness, autosomal recessive, 35 (DFNB35)
  • 亚细胞定位：
    Nucleus. Cytoplasm. Chromosome.
  • 蛋白家族：
    Nuclear hormone receptor family, NR3 subfamily
  • 数据库链接：

    HGNC: 3473

    OMIM: 602167

    KEGG: hsa:2103

    STRING: 9606.ENSP00000370270

    UniGene: Hs.435845