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  4. Recombinant Human Sperm-associated antigen 11A (SPAG11A)

Recombinant Human Sperm-associated antigen 11A (SPAG11A)

  • 货号：
    CSB-YP754245HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP754245HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP754245HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP754245HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP754245HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SPAG11A
  • Uniprot No.：
  • 别名：
    SPAG11A; EP2; HE2; Sperm-associated antigen 11A; Human epididymis-specific protein 2; He2; Protein EP2; Sperm antigen HE2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    26-123
  • 氨基酸序列
    RHVNH SATEALGELR ERAPGQGTNG FQLLRHAVKR DLLPPRTPPY QVHISHQEAR GPSFKICVGF LGPRWARGCS TGNEKYHLPY AARDLQTFFL PFW
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May have antimicrobial activity. May also play a role sperm maturation, storage, and protection.
  • 基因功能参考文献：
    1. we report the three dimensional structure of the human SPAG11B proteins and their C-terminal peptides. web-based hydropathy, amphipathicity, and topology (WHAT) analyses and grand average of hydropathy PMID: 25573789
    2. Isoform C of SPAG11B encodes a peptide with antimicrobial activity against E. coli. PMID: 16411022
    3. Combination of two proteins, SPAG11B and TEX101, can be used for differential diagnosis of azoospermia PMID: 21933954
    4. SPAG11B/D is both a substrate and a potent inhibitor of TPSAB1 activity. PMID: 19535787
    5. HE2 peptides were detected in human epididymal epithelium, epididymal fluid, and ejaculate PMID: 12193388
    6. HE2 transcriptional and translational products normally expressed in the caput epididymidis were not affected by vasectomy. PMID: 14662784
    7. EP2 expression is more widespread in male reproductive tract than realized previously. Activity of every EP2 variant tested is antibacterial. Further investigation may reveal additional roles for EP2 peptides in primate male reproductive tract. PMID: 15229135
    8. In the chimpanzee epididymis, several mRNA HE2/EP2 variants are produced. Of these, three cDNAs code for two different protein sequences that have a cysteine distribution characteristic for beta-defensins. PMID: 10819450
    9. The human HE2/EP2 gene is the fusion product of two ancestral beta-defensin genes. During its evolution, the gene has acquired additional exons whose inclusion produces new message variants that encode peptides unrelated to defensins. PMID: 11259252

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    SPAG11 family
  • 数据库链接：

    HGNC: 33342

    OMIM: 606560

    KEGG: hsa:653423

    STRING: 9606.ENSP00000381480

    UniGene: Hs.2717